Imperial College London
Alternate

ProfessorAnnaHansell

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

a.hansell

 
 
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Location

 

UG42Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cai,
author = {Cai, Y and Hansell, A and Hodgson, S and Elliott, P and Fecht, D and Gulliver, J and Key, T and de, Hoogh K and Hveem, K and Morley, D and Vienneau, D and Blangiardo, M},
journal = {Environment International},
title = {Road traffic noise, air pollution and incident cardiovascular disease: a joint analysis of the HUNT, EPIC-Oxford and UK Biobank cohorts},
url = {http://hdl.handle.net/10044/1/57346},
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: This study aimed to investigate  the effects of long-term exposure to road traffic noiseand air pollutionon incident cardiovascular disease (CVD)in three large cohorts: HUNT, EPIC-Oxford and UK Biobank. Methods: In pooled complete-casesample of the three cohorts from Norway and the United Kingdom(N=355,732), 21,081  incident  all  CVD  cases  including 5,259ischemic  heart  disease  (IHD)and  2,871cerebrovascular cases were  ascertained between baseline (1993-2010)and end of follow-up (2008-2013)through medical recordlinkage. Annual mean 24-hour weighted road traffic noise(Lden) and air pollution (particulate matter with aerodynamic diameter ≤10 μm [PM10],≤2.5 μm [PM2.5]andnitrogen 39dioxide[NO2])exposure at baseline address was modelled using a simplified version of the Common Noise  Assessment  Methods  in  Europe  (CNOSSOS-EU)and  European-wide  Land  Use  Regression models.Individual-level covariate data  were  harmonised  and physically pooled  across  the  three cohorts. Analysis was via Cox proportional hazard model with mutual adjustmentsforboth noise and air pollution andpotential confounders.  Results: No significant associations were found between annual mean Ldenand incidentCVD,IHD or cerebrovascular disease  in the overall populationexcept that the association withincident IHD was significantamong  current-smokers.In  the fully  adjusted models including  adjustmentfor Lden,  an interquartile  range  (IQR)  higher  PM10(4.1μg/m3)  or  PM2.5(1.4μg/m3)  was  associated  witha5.8% (95%CI:  2.5%-9.3%)  and  3.7%  (95%CI:  0.2%-7.4%) higherrisk  for all incident  CVD respectively.  No significant associations were found between NO2and any of the CVD outcomes.   Conclusions: We found suggestive evidence of a possible association between road traffic noise and incident IHD, consistent with current literature. Long-term particulate air pollution exposure, even at concentrations  below  current  European  air  quality  standards,  w
AU  - Cai,Y
AU  - Hansell,A
AU  - Hodgson,S
AU  - Elliott,P
AU  - Fecht,D
AU  - Gulliver,J
AU  - Key,T
AU  - de,Hoogh K
AU  - Hveem,K
AU  - Morley,D
AU  - Vienneau,D
AU  - Blangiardo,M
SN  - 0160-4120
TI  - Road traffic noise, air pollution and incident cardiovascular disease: a joint analysis of the HUNT, EPIC-Oxford and UK Biobank cohorts
T2  - Environment International
UR  - http://hdl.handle.net/10044/1/57346
ER  -
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