Imperial College London

DrAylinHanyaloglu

Faculty of MedicineDepartment of Surgery & Cancer

Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 2128a.hanyaloglu Website

 
 
//

Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
//

Location

 

2006Institute of Reproductive and Developmental BiologyHammersmith Campus

//

Summary

 

Summary

Qualification and Personal History

  • PhD in Molecular Endocrinology 2002 (with Distinction), University Western Australia (Group of Prof. Karin Eidne)
  • Postdoctoral work at University of California San Francisco) (2002-2007) (Group of Prof. Mark von Zastrow)
  • Joined Imperial College London in August 2007 as a Research Team Leader (G protein-coupled receptor (GPCR) Signalling Group) and Lecturer

 

Research Interests

Understanding fundamental cell biological mechanisms regulating G protein-coupled receptor (GPCR) signal transduction and applying these mechanisms to understand the role of this superfamily of receptors in diverse physiological and pathophysiological systems.

Current Projects

  • Molecular mechanisms regulating signal activation of the gonadotrophin hormone receptors (lutenizing hormone and follicle stimulating hormone) via dimerization and membrane trafficking
  • Role of prostglandin receptor action in the pregnant human myomterium and the signaling pathways involved in labour and pre-term labour
  • Human chorionic gonadotrophin hormone action in human endometrium and reprogramming of receptor activity during differentitaion
  • Role of free fatty receptors (GPR43 and GPR120) in gut-adipose axis and brown adipocyte function.

This work is funded by the Wellcome Trust, BBSRC and Genesis Research Trust. 

 

Selected Publications

Journal Articles

West C, Hanyaloglu AC, 2015, Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and Disease., Mol Endocrinol, Vol:29, Pages:1095-1106

Jonas KC, Fanelli F, Huhtaniemi IT, et al., 2015, Single Molecule Analysis of Functionally Asymmetric G Protein-coupled Receptor (GPCR) Oligomers Reveals Diverse Spatial and Structural Assemblies, Journal of Biological Chemistry, Vol:290, ISSN:0021-9258, Pages:3875-3892

Sposini S, Caltabiano G, Hanyaloglu AC, et al., 2015, Identification of transmembrane domains that regulate spatial arrangements and activity of prokineticin receptor 2 dimers., Mol Cell Endocrinol, Vol:399, Pages:362-372

Kandola MK, Sykes L, Lee YS, et al., 2014, EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium, Endocrinology, Vol:155, ISSN:0013-7227, Pages:605-617

Jonas KC, Rivero-Mueller A, Huhtaniemi IT, et al., 2013, G Protein-Coupled Receptor Transactivation: From Molecules to Mice, Methods in Cell Biology, Vol:117, ISSN:0091-679X, Pages:433-450

Jean-Alphonse F, Bowersox S, Chen S, et al., 2014, Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments, Journal of Biological Chemistry, Vol:289, ISSN:0021-9258, Pages:3960-3977

Hanyaloglu AC, von Zastrow M, 2008, Regulation of GPCRs by Endocytic membrane trafficking and its potential implications, Annual Review of Pharmacology and Toxicology, Vol:48, ISSN:0362-1642, Pages:537-568

Chapters

Jonas KC, Huhtaniemi I, Hanyaloglu AC, 2016, Single-molecule resolution of G protein-coupled receptor (GPCR) complexes, Editor(s): Shukla, ELSEVIER ACADEMIC PRESS INC, Pages:55-72, ISBN:978-0-12-803595-5

More Publications