Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Cell Biology



+44 (0)20 7594 2128a.hanyaloglu Website




Miss Kiran Dosanjh +44 (0)20 7594 2176




2009Institute of Reproductive and Developmental BiologyHammersmith Campus






BibTex format

author = {Hanyaloglu, AC},
doi = {10.1016/bs.ircmb.2018.03.001},
journal = {International Review of Cell and Molecular Biology},
pages = {93--131},
title = {Advances in membrane tafficking and endosomal signaling of G protein-coupled receptors},
url = {},
volume = {339},
year = {2018}

RIS format (EndNote, RefMan)

AB - The integration of GPCR signaling with membrane trafficking, as a single orchestrated system, is a theme increasingly evident with the growing reports of GPCR endosomal signaling. Once viewed as a mechanism to regulate cell surface heterotrimeric G protein signaling, the endocytic trafficking system is complex, highly compartmentalized, yet deeply interconnected with cell signaling. The organization of receptors into distinct plasma membrane signalosomes, biochemically distinct endosomal populations, endosomal microdomains, and its communication with distinct subcellular organelles such as the Golgi provides multiple unique signaling platforms that are critical for specifying receptor function physiologically and pathophysiologically. In this chapter I discuss our emerging understanding in the endocytic trafficking systems employed by GPCRs and their novel roles in spatial control of signaling. Given the extensive roles that GPCRs play in vivo, these evolving models are starting to provide mechanistic understanding of distinct diseases and provide novel therapeutic avenues that are proving to be viable targets.
AU - Hanyaloglu,AC
DO - 10.1016/bs.ircmb.2018.03.001
EP - 131
PY - 2018///
SN - 1937-6448
SP - 93
TI - Advances in membrane tafficking and endosomal signaling of G protein-coupled receptors
T2 - International Review of Cell and Molecular Biology
UR -
UR -
VL - 339
ER -