Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Cell Biology



+44 (0)20 7594 2128a.hanyaloglu Website




Miss Kiran Dosanjh +44 (0)20 7594 2176




2009Institute of Reproductive and Developmental BiologyHammersmith Campus






BibTex format

author = {Sposini, S and Hanyaloglu, AC},
doi = {10.1007/978-3-319-96704-2_10},
journal = {Prog Mol Subcell Biol},
pages = {273--299},
title = {Evolving View of Membrane Trafficking and Signaling Systems for G Protein-Coupled Receptors.},
url = {},
volume = {57},
year = {2018}

RIS format (EndNote, RefMan)

AB - The G protein-coupled receptor (GPCR) superfamily activates complex signal pathways, yet untangling these signaling systems to understand how specificity in receptor signaling pathways is achieved, has been a challenging question. The roles of membrane trafficking in GPCR signal regulation has undergone a recent paradigm shift, from a mechanism that programs the plasma membrane G protein signaling profile to providing distinct signaling platforms critical for specifying receptor function in vivo. In this chapter, we discuss this evolution of our understanding in the endocytic trafficking systems employed by GPCRs, and how such systems play a deeply integrated role with signaling. We describe recent studies that suggest that the endomembrane compartment can provide a mechanism to both specify, and yet also diversify, GPCR signal transduction. These new evolving models could aid mechanistic understanding of complex disease and provide novel therapeutic avenues.
AU - Sposini,S
AU - Hanyaloglu,AC
DO - 10.1007/978-3-319-96704-2_10
EP - 299
PY - 2018///
SN - 0079-6484
SP - 273
TI - Evolving View of Membrane Trafficking and Signaling Systems for G Protein-Coupled Receptors.
T2 - Prog Mol Subcell Biol
UR -
UR -
VL - 57
ER -