Imperial College London

DrAylinHanyaloglu

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 2128a.hanyaloglu Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

2009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sayers:2018:10.3389/fendo.2018.00653,
author = {Sayers, N and Hanyaloglu, AC},
doi = {10.3389/fendo.2018.00653},
journal = {Front Endocrinol (Lausanne)},
title = {Intracellular Follicle-Stimulating Hormone Receptor Trafficking and Signaling.},
url = {http://dx.doi.org/10.3389/fendo.2018.00653},
volume = {9},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Models of G protein-coupled receptor (GPCR) signaling have dramatically altered over the past two decades. Indeed, GPCRs such as the follicle-stimulating hormone receptor (FSHR) have contributed to these new emerging models. We now understand that receptor signaling is highly organized at a spatial level, whereby signaling not only occurs from the plasma membrane but distinct intracellular compartments. Recent studies in the role of membrane trafficking and spatial organization of GPCR signaling in regulating gonadotropin hormone receptor activity has identified novel intracellular compartments, which are tightly linked with receptor signaling and reciprocally regulated by the cellular trafficking machinery. Understanding the impact of these cell biological mechanisms to physiology and pathophysiology is emerging for certain GPCRs. However, for FSHR, the potential impact in both health and disease and the therapeutic possibilities of these newly identified systems is currently unknown, but offers the potential to reassess prior strategies, or unveil novel opportunities, in targeting this receptor.
AU - Sayers,N
AU - Hanyaloglu,AC
DO - 10.3389/fendo.2018.00653
PY - 2018///
SN - 1664-2392
TI - Intracellular Follicle-Stimulating Hormone Receptor Trafficking and Signaling.
T2 - Front Endocrinol (Lausanne)
UR - http://dx.doi.org/10.3389/fendo.2018.00653
UR - https://www.ncbi.nlm.nih.gov/pubmed/30450081
VL - 9
ER -