Summary
Qualification and Personal History
- PhD in Molecular Endocrinology 2002 (with Distinction), University Western Australia
- Postdoctoral work at University of California San Francisco) (2002-2007)
- Joined Imperial College London in August 2007 as Group Leader of the G protein-coupled receptor (GPCR) Signalling Group
Research Interests
Understanding fundamental cell biological mechanisms regulating G protein-coupled receptor (GPCR) signal transduction and applying these mechanisms in diverse physiological and pathophysiological systems.
Current Projects
- Spatial control of gonadotrophin hormone receptor (luteinizing hormone and follicle stimulating hormone) activity
- Molecular mechanisms and functional role of GPCR dimerization and oligomerization on receptor activity via super-resolution imaging
- Prostaglandin and oxytocin receptor action in the pregnant human myometrium and the signalling pathways modulated in labour and pre-term labour
- GPCR action in the human endometrium and reprogramming of receptor activity in recurrent pregnancy loss and endometrial cancer
- Molecular regulation of metabolite sensing GPCRs in intestinal function
- Targeting Kisspeptin receptor activation in women's reproductive health
This work is funded by the Wellcome Trust, BBSRC, MRC and Genesis Research Trust.
Selected Publications
Journal Articles
Caengprasath N, Gonzalez Abuin N, Shchepinova M, et al., 2020, Internalization-dependent free fatty acid receptor 2 signaling is essential for propionate- induced anorectic gut hormone release, Iscience, Vol:23, ISSN:2589-0042
West C, Hanyaloglu AC, 2015, Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and Disease., Molecular Endocrinology, Vol:29, ISSN:1944-9917, Pages:1095-1106
Jonas KC, Fanelli F, Huhtaniemi IT, et al., 2015, Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies, Journal of Biological Chemistry, Vol:290, ISSN:1083-351X, Pages:3875-3892
Sposini S, Caltabiano G, Hanyaloglu AC, et al., 2014, Identification of transmembrane domains that regulate spatial arrangements and activity of prokineticin receptor 2 dimers, Molecular and Cellular Endocrinology, Vol:399, ISSN:1872-8057, Pages:362-372
Jean-Alphonse F, Bowersox S, Chen S, et al., 2014, Spatially restricted G protein-coupled receptor signaling via divergent endocytic compartments, Journal of Biological Chemistry, Vol:289, ISSN:1083-351X, Pages:3960-3977
Kandola MK, Sykes L, Lee YS, et al., 2013, EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium, Endocrinology, Vol:Epub ahead of print
Jonas KC, Rivero-Mueller A, Huhtaniemi IT, et al., 2013, G Protein-Coupled Receptor Transactivation: From Molecules to Mice, Methods in Cell Biology, Vol:117, ISSN:0091-679X, Pages:433-450
Hanyaloglu AC, von Zastrow M, 2008, Regulation of GPCRs by Membrane Trafficking and Its Potential Implications, Annual Review of Pharmacology and Toxicology, Vol:Epub ahead of print
Chapters
Jonas KC, Huhtaniemi I, Hanyaloglu AC, 2016, Single-molecule resolution of G protein-coupled receptor (GPCR) complexes, G PROTEIN-COUPLED RECEPTORS: SIGNALING, TRAFFICKING AND REGULATION, Editor(s): Shukla, ELSEVIER ACADEMIC PRESS INC, Pages:55-72, ISBN:978-0-12-803595-5