Imperial College London

DrAylinHanyaloglu

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Reader in Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 2128a.hanyaloglu Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

2009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jonas:2014:10.1074/jbc.M114.622498,
author = {Jonas, KC and Fanelli, F and Huhtaniemi, IT and Hanyaloglu, AC},
doi = {10.1074/jbc.M114.622498},
journal = {Journal of Biological Chemistry},
pages = {3875--3892},
title = {Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies},
url = {http://dx.doi.org/10.1074/jbc.M114.622498},
volume = {290},
year = {2014}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Background: GPCRs form complex oligomers whose role in signaling is poorly understood.Results: Super-resolution imaging of functionally asymmetric oligomers reveals diverse functional and structural organizationsand the ability to alter signal responses.Conclusion: GPCR oligomers may fine-tune receptor signaling by altering the functional role of individual protomers.Significance: Distinct oligomers could be exploited pharmacologically to improve efficacy, selectivity, and/or specificity.
AU - Jonas,KC
AU - Fanelli,F
AU - Huhtaniemi,IT
AU - Hanyaloglu,AC
DO - 10.1074/jbc.M114.622498
EP - 3892
PY - 2014///
SN - 1083-351X
SP - 3875
TI - Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies
T2 - Journal of Biological Chemistry
UR - http://dx.doi.org/10.1074/jbc.M114.622498
UR - http://hdl.handle.net/10044/1/31311
VL - 290
ER -