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@article{Jean-Alphonse:2010,
author = {Jean-Alphonse, F and Hanyaloglu, AC},
journal = {Molecular and Cellular Endocrinology},
pages = {205--214},
title = {Regulation of GPCR signal networks via membrane trafficking},
volume = {331},
year = {2010}
}

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TY  - JOUR
AB  - -protein-coupled receptors (GPCRs) are a superfamily of cell surface signaling proteins that act as central molecular activators and integrators in all endocrine systems. Membrane trafficking of GPCRs is a fundamental process in shaping extensive signaling networks activated by these receptors. Mounting evidence has identified an increasingly complex network of pathways and protein interactions that a GPCR can traverse and associate with, indicating a multi-level system of regulation. This review will discuss the recent developments in how GPCRs are trafficked to the cell surface as newly synthesized receptors, their recruitment to the clathrin-mediated pathway for endocytosis, and their sorting to subsequent divergent post-endocytic fates, focusing primarily on hormone-activated GPCRs. Current models depicting the classic roles membrane trafficking plays in GPCR signaling have evolved to a highly regulated and complex system than previously appreciated. These developments impart key mechanistic information on how spatial and temporal aspects of GPCR signaling may be integrated and could provide pathway-specific targets to be exploited for therapeutic intervention.
AU  - Jean-Alphonse,F
AU  - Hanyaloglu,AC
EP  - 214
PY  - 2010///
SP  - 205
TI  - Regulation of GPCR signal networks via membrane trafficking
T2  - Molecular and Cellular Endocrinology
VL  - 331
ER  -

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