Imperial College London
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ProfessorAylinHanyaloglu

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor in Molecular Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2128a.hanyaloglu Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

2009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nikolopoulou:2014:10.1194/jlr.M049551,
author = {Nikolopoulou, E and Papacleovoulou, G and Jean-Alphonse, F and Grimaldi, G and Parker, MG and Hanyaloglu, AC and Christian, M},
doi = {10.1194/jlr.M049551},
journal = {Journal of Lipid Research},
pages = {2479--2490},
title = {Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential},
url = {http://dx.doi.org/10.1194/jlr.M049551},
volume = {55},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation. AA caused the upregulation of fatty acid binding protein 4 (FABP4/aP2) following 24 h of differentiation. This was mediated by the prostaglandin F2α (PGF2α), as inhibition of cyclooxygenases or PGF2α receptor signaling counteracted the AA-mediated aP2 induction. In addition, calcium, protein kinase C, and ERK are all key elements of the pathway through which AA induces the expression of aP2. We also show that treatment with AA during the first 24 h of differentiation upregulates the expression of the transcription factor Fos-related antigen 1 (Fra-1) via the same pathway. Finally, treatment with AA for 24 h at the beginning of the adipocyte differentiation is sufficient to inhibit the late stages of adipogenesis through a Fra-1-dependent pathway, as Fra-1 knockdown rescued adipogenesis. Our data show that AA is able to program the differentiation potential of preadipocytes by regulating gene expression at the early stages of adipogenesis.
AU  - Nikolopoulou,E
AU  - Papacleovoulou,G
AU  - Jean-Alphonse,F
AU  - Grimaldi,G
AU  - Parker,MG
AU  - Hanyaloglu,AC
AU  - Christian,M
DO  - 10.1194/jlr.M049551
EP  - 2490
PY  - 2014///
SN  - 0022-2275
SP  - 2479
TI  - Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential
T2  - Journal of Lipid Research
UR  - http://dx.doi.org/10.1194/jlr.M049551
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345519900005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/54468
VL  - 55
ER  -
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