Imperial College London
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ProfessorAylinHanyaloglu

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor in Molecular Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2128a.hanyaloglu Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

2009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jonas:2015:10.1074/jbc.M114.622498,
author = {Jonas, KC and Fanelli, F and Huhtaniemi, IT and Hanyaloglu, AC},
doi = {10.1074/jbc.M114.622498},
journal = {Journal of Biological Chemistry},
pages = {3875--3892},
title = {Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies},
url = {http://dx.doi.org/10.1074/jbc.M114.622498},
volume = {290},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: GPCRs form complex oligomers whose role in signaling is poorly understood.Results: Super-resolution imaging of functionally asymmetric oligomers reveals diverse functional and structural organizationsand the ability to alter signal responses.Conclusion: GPCR oligomers may fine-tune receptor signaling by altering the functional role of individual protomers.Significance: Distinct oligomers could be exploited pharmacologically to improve efficacy, selectivity, and/or specificity.
AU  - Jonas,KC
AU  - Fanelli,F
AU  - Huhtaniemi,IT
AU  - Hanyaloglu,AC
DO  - 10.1074/jbc.M114.622498
EP  - 3892
PY  - 2015///
SN  - 1083-351X
SP  - 3875
TI  - Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies
T2  - Journal of Biological Chemistry
UR  - http://dx.doi.org/10.1074/jbc.M114.622498
UR  - https://www.sciencedirect.com/science/article/pii/S0021925819469780?via%3Dihub
UR  - http://hdl.handle.net/10044/1/31311
VL  - 290
ER  -
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