Imperial College London
Portrait Picture

ProfessorAylinHanyaloglu

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor in Molecular Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2128a.hanyaloglu Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

2009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sposini:2017:10.1016/j.bcp.2017.04.028,
author = {Sposini, S and Hanyaloglu, AC},
doi = {10.1016/j.bcp.2017.04.028},
journal = {Biochemical Pharmacology},
pages = {1--9},
title = {Spatial encryption of G protein-coupled receptor signaling in endosomes; mechanisms and applications},
url = {http://dx.doi.org/10.1016/j.bcp.2017.04.028},
volume = {143},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Within any cellular signaling system membrane trafficking is a critical mechanism for cells to translate complex networks into specific downstream responses, including the signal pathways activated by the superfamily of G protein-coupled receptors (GPCRs). Classically, membrane trafficking is viewed as a mechanism to regulate ligand sensitivity of a target tissue by controlling the level of surface receptors. Recent studies, however, have not only highlighted that GPCR trafficking is a tightly regulated process critical for spatio-temporal control of signaling, but that heterotrimeric G protein signaling can also be reactivated or continue to signal from distinct endocytic compartments, and even endosomal microdomains. The significance of spatio-temporal control will be discussed, not only with respect to how these novel molecular pathways impact our basic understanding of cellular regulation, but also our view of how aberrant signaling can result in disease. Furthermore, these mechanisms offer the potential application for novel therapeutic strategies to identify GPCR compounds with high specificity in their actions
AU  - Sposini,S
AU  - Hanyaloglu,AC
DO  - 10.1016/j.bcp.2017.04.028
EP  - 9
PY  - 2017///
SN  - 1873-2968
SP  - 1
TI  - Spatial encryption of G protein-coupled receptor signaling in endosomes; mechanisms and applications
T2  - Biochemical Pharmacology
UR  - http://dx.doi.org/10.1016/j.bcp.2017.04.028
UR  - http://hdl.handle.net/10044/1/48323
VL  - 143
ER  -
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