Imperial College London
Alternate

Emeritus ProfessorAnitaHoldcroft

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Reader in Anaesthetics
 
 
 
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Contact

 

a.holdcroft

 
 
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Location

 

G4.42Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Publication Type
Year
to

121 results found

Nazir MS, Holdcroft A, 2009, Local anaesthetic drugs: adverse effects as reported through the ADROIT system in the UK, PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Vol: 18, Pages: 1000-1006, ISSN: 1053-8569

Journal article

Shah H, Smythe J, Hanafiah Z, Williams GJP, Holdcroft Aet al., 2009, Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings, BURNS, Vol: 35, Pages: 798-801, ISSN: 0305-4179

Journal article

Sidhu R, Rajashekhar P, Lavin VL, Parry J, Attwood J, Holdcroft A, Sanders DSet al., 2009, The gender imbalance in academic medicine: a study of female authorship in the United Kingdom, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 102, Pages: 337-342, ISSN: 0141-0768

Journal article

Richardson J, Holdcroft A, 2009, Gender differences and pain medication., Womens Health (Lond), Vol: 5, Pages: 79-90

Subtle genetic and psychological variations are increasingly recognized to contribute to pain and analgesic efficacy and safety. The influence of sex on this relationship remains poorly understood, particularly in humans. The issue is complicated by the overlay of gender onto physical sex, and its associated stereotypes and expectations. Women appear to use more pain-relieving medications than men; however, it remains unclear whether these observations represent true differences in analgesic usage patterns, or reporting bias. Differences in analgesic efficacy relating to body composition, metabolism and hormonal profiles have been demonstrated. Psychological and social elements of gender have also been associated with altered pain experiences and analgesic use profiles, albeit with significant individual variations. Intra-group differences may ultimately prove more important than sex differences. Further research may unravel the various threads linking gender and sex effects on analgesia with the aim of individualizing analgesia to optimize pain relief.

Journal article

Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB, Gold MS, Holdcroft A, Lautenbacher S, Mayer EA, Mogil JS, Murphy AZ, Traub RJet al., 2007, Studying sex and gender differences in pain and analgesia: A consensus report, PAIN, Vol: 132, Pages: S26-S45, ISSN: 0304-3959

Journal article

Fortescue C, Wee MYK, Malhotra S, Yentis SM, Holdcroft Aet al., 2007, Is preparation for emergency obstetric anaesthesia adequate? A maternal questionnaire survey, INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, Vol: 16, Pages: 336-340, ISSN: 0959-289X

Journal article

Sandhu B, Margerison C, Holdcroft A, 2007, Women in the UK academic medicine workforce, MEDICAL EDUCATION, Vol: 41, Pages: 909-914, ISSN: 0308-0110

Journal article

Richardson J, Holdcroft A, 2007, Results of forty years Yellow Card reporting for commonly used perioperative analgesic drugs, PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Vol: 16, Pages: 687-694, ISSN: 1053-8569

Journal article

Holdcroft A, 2007, UK drug analysis prints and anaesthetic adverse drug reactions, PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Vol: 16, Pages: 316-328, ISSN: 1053-8569

Journal article

Lim C, Keogh E, Stephens D, Holdcroft Aet al., 2007, Sex differences in pain: the role of ethnicity, Meeting of the Anaesthetic-Research-Society, Publisher: ELSEVIER SCI LTD, Pages: 281P-281P, ISSN: 0007-0912

Conference paper

Holdcroft A, Dore C, 2007, Cannabinoids for postoperative pain., Anesthesiology, Vol: 106, Pages: 397-398, ISSN: 0003-3022

Journal article

Yeo ST, Holdcroft A, Yentis SM, Stewart Aet al., 2007, Analgesia with sevoflurane during labour: I. Determination of the optimum concentration, BRITISH JOURNAL OF ANAESTHESIA, Vol: 98, Pages: 105-109, ISSN: 0007-0912

Journal article

Holdcroft A, 2007, Gender bias in research: how does it affect evidence based medicine?, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 100, Pages: 2-3, ISSN: 0141-0768

Journal article

Yeo ST, Holdcroft A, Yentis SM, Stewart A, Bassett Pet al., 2007, Analgesia with sevoflurane during labour: II. Sevoflurane compared with Entonox for labour analgesia, BRITISH JOURNAL OF ANAESTHESIA, Vol: 98, Pages: 110-115, ISSN: 0007-0912

Journal article

Holdcroft A, 2007, Integrating the dimensions of sex and gender into basic life sciences research: methodologic and ethical issues., Gend Med, Vol: 4 Suppl B, Pages: S64-S74, ISSN: 1550-8579

BACKGROUND: The research process -- from study design and selecting a species and its husbandry, through the experiment, analysis, peer review, and publication -- is rarely subject to questions about sex or gender differences in mainstream life sciences research. However, the impact of sex and gender on these processes is important in explaining biological variations and presentation of symptoms and diseases. OBJECTIVE: This review aims to challenge assumptions and to develop opportunities to mainstream sex and gender in basic scientific research. METHODS: Questions about the mechanisms of sex and gender effects were reviewed in relation to biological, environmental, social, and psychological interactions. Gender variations, in respect to aging, socializing, and reproduction, that are present in human populations but are rarely featured in laboratory research were considered to more effectively translate animal research into clinical health care. RESULTS: Methodologic approaches to address the present lack of a gender dimension in research include actively reducing variations through attention to physical factors, biological rhythms, and experimental design. In addition, through genomic and acute nongenomic activity, hormones may compound effects through multiple small sex differences that occur during the course of an acute pathologic event. Furthermore, the many exogenous sex steroid hormones and their congeners used in medicine (eg, in contraception and cancer therapies) may add to these effects. CONCLUSIONS: The studies reviewed provide evidence that sex and gender are determinants of many outcomes in life science research. To embed the gender dimension into basic scientific research, a broad approach -- gender mainstreaming -- is warranted. One example is the use of review boards (eg, animal ethical review boards and journal peer-review boards) in which gender-related standardized questions can be asked about study design and analysis. A more fundamental approa

Journal article

Pickering E, Guz A, Semple S, Murphy K, Holdcroft Aet al., 2006, Breathlessness measured by clamping end-tidal carbon dioxide: Limitations of the breathing system, Annual Meeting of the Anaesthetic-Research-Society, Publisher: ELSEVIER SCI LTD, Pages: 437P-437P, ISSN: 0007-0912

Conference paper

Holdcroft A, Maze M, Doré C, Tebbs S, Thompson Set al., 2006, A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management, ANESTHESIOLOGY, Vol: 104, Pages: 1040-1046, ISSN: 0003-3022

Journal article

Sabir N, Yentis SM, Holdcroft A, 2006, A national survey of obstetric anaesthetic handovers, ANAESTHESIA, Vol: 61, Pages: 376-380, ISSN: 0003-2409

Journal article

Light KP, Lovell AT, Butt H, Fauvel NJ, Holdcroft Aet al., 2006, Adverse effects of neuromuscular blocking agents based on yellow card reporting in the UK: are there differences between males and females?, PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Vol: 15, Pages: 151-160, ISSN: 1053-8569

Journal article

McGinn K, Keogh E, Stephens D, Holdcroft Aet al., 2006, Sex and site differences in human pain: the role of visual cues and stress hormone response, Meeting of the Anaesthetic-Research-Society, Publisher: ELSEVIER SCI LTD, Pages: 275P-275P, ISSN: 0007-0912

Conference paper

Richardson J, Holdcroft A, 2006, Results of 40 yr Yellow Card reporting for commonly used perioperative analgesic drugs, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 276P-276P, ISSN: 0007-0912

Conference paper

Keogh E, Hughes S, Ellery D, Daniel C, Holdcroft Aet al., 2006, Psychosocial influences on women's experience of planned elective cesarean section, PSYCHOSOMATIC MEDICINE, Vol: 68, Pages: 167-174, ISSN: 0033-3174

Journal article

Howard J, Anie KA, Holdcroft A, Korn S, Davies SCet al., 2005, Cannabis use in sickle cell disease: a questionnaire study, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 131, Pages: 123-128, ISSN: 0007-1048

Journal article

Woolridge E, Barton S, Samuel J, Osorio J, Dougherty A, Holdcroft Aet al., 2005, Cannabis use in HIV for pain and other medical symptoms, JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, Vol: 29, Pages: 358-367, ISSN: 0885-3924

Journal article

Gopinath P, Wan E, Holdcroft A, Facer P, Davis JB, Smith GD, Bountra C, Anand Pet al., 2005, Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain., BMC Women's Health, Vol: 5, Pages: 1-9, ISSN: 1472-6874

BACKGROUND: Breast pain and tenderness affects 70% of women at some time. These symptoms have been attributed to stretching of the nerves with increase in breast size, but tissue mechanisms are poorly understood. METHODS: Eighteen patients (n = 12 breast reduction and n = 6 breast reconstruction) were recruited and assessed for breast pain by clinical questionnaire. Breast skin biopsies from each patient were examined using immunohistological methods with specific antibodies to the capsaicin receptor TRPV1, related vanilloid thermoreceptors TRPV3 and TRPV4, and nerve growth factor (NGF). RESULTS: TRPV1-positive intra-epidermal nerve fibres were significantly increased in patients with breast pain and tenderness (TRPV1 fibres / mm epidermis, median [range] - no pain group, n = 8, 0.69 [0-1.27]; pain group, n = 10, 2.15 [0.77-4.38]; p = 0.0009). Nerve Growth Factor, which up-regulates TRPV1 and induces nerve sprouting, was present basal keratinocytes: some breast pain specimens also showed NGF staining in supra-basal keratinocytes. TRPV4-immunoreactive fibres were present in sub-epidermis but not significantly changed in painful breast tissue. Both TRPV3 and TRPV4 were significantly increased in keratinocytes in breast pain tissues; TRPV3, median [range] - no pain group, n = 6, 0.75 [0-2]; pain group, n = 11, 2 123, p = 0.008; TRPV4, median [range] - no pain group, n = 6, [0-1]; pain group, n = 11, 1 [0.5-2], p = 0.014). CONCLUSION: Increased TRPV1 intra-epidermal nerve fibres could represent collateral sprouts, or re-innervation following nerve stretch and damage by polymodal nociceptors. Selective TRPV1-blockers may provide new therapy in breast pain. The role of TRPV3 and TRPV4 changes in keratinocytes deserve further study.

Journal article

Patel A, Keogh E, Stephens D, Holdcroft Aet al., 2005, Sex differences in pain: a new methodological approach, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 402P-402P, ISSN: 0007-0912

Conference paper

Pickering E, Nazir MS, Guz A, Semple S, Murphy K, Holdcroft Aet al., 2005, Acute breathlessness measured by clamping the end-tidal carbon dioxide, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 400P-401P, ISSN: 0007-0912

Conference paper

Holdcroft A, Hall L, Hamilton G, Counsell SJ, Bydder GM, Bell JDet al., 2005, Phosphorus-31 brain MR spectroscopy in women during and after pregnancy compared with nonpregnant control subjects, AMERICAN JOURNAL OF NEURORADIOLOGY, Vol: 26, Pages: 352-356, ISSN: 0195-6108

Journal article

Holdcroft A, Doré C, Phillips P, Maze M, Hanna Met al., 2004, Cannabis in postoperative pain:: a pharmacokinetic study, Meeting of the Anaesthetic-Research-Society, Publisher: OXFORD UNIV PRESS, Pages: 609P-610P, ISSN: 0007-0912

Conference paper

Howard J, Anie K, Holdcroft A, Korn S, Davies SCet al., 2004, Cannabis use in sickle cell disease: results of an anonymous patient survey, Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: BLACKWELL PUBLISHING LTD, Pages: 27-27, ISSN: 0007-1048

Conference paper

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