Imperial College London
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PROFESSOR AJIT LALVANI

Faculty of Medicine, National Heart & Lung Institute

Chair in Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 0883a.lalvani

 
 
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Assistant

 

Dr Luis Berrocal Almanza +44 (0)20 7594 3721

 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Singanayagam:2016:10.5588/ijtld.16.0159,
author = {Singanayagam, A and Manalan, K and Connell, DW and Chalmers, JD and Sridhar, S and Ritchie, AI and Lalvani, A and Wickremasinghe, M and Kon, OM},
doi = {10.5588/ijtld.16.0159},
journal = {International Journal of Tuberculosis and Lung Disease},
pages = {1653--1660},
title = {Evaluation of serum inflammatory biomarkers as predictors of treatment outcome in pulmonary tuberculosis},
url = {http://dx.doi.org/10.5588/ijtld.16.0159},
volume = {20},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: To evaluate C-reactive protein (CRP), globulin and white blood cell (WBC) count as predictors of treatment outcome in pulmonary tuberculosis (PTB).METHODS: An observational study of patients with active PTB was conducted at a tertiary centre. All patients had serum CRP, globulin and WBC measured at baseline and at 2 months following commencement of treatment. The outcome of interest was requirement for extension of treatment beyond 6 months.RESULTS: There were 226 patients included in the study. Serum globulin >45 g/l was the only baseline biomarker evaluated that independently predicted requirement for treatment extension (OR 3.42, 95%CI 1.59–7.32, P < 0.001). An elevated globulin level that failed to normalise at 2 months was also associated with increased requirement for treatment extension (63.9% vs. 5.1%, P < 0.001), and had a low negative likelihood ratio (0.07) for exclusion of requirement for treatment extension. On multivariable analysis, an elevated globulin that failed to normalise at 2 months was independently associated with requirement for treatment extension (OR 6.13, 95%CI 2.23–16.80, P < 0.001).CONCLUSIONS: Serum globulin independently predicts requirement for treatment extension in PTB and outperforms CRP and WBC as a predictive biomarker. Normalisation of globulin at 2 months following treatment commencement is associated with low risk of requirement for treatment extension.
AU  - Singanayagam,A
AU  - Manalan,K
AU  - Connell,DW
AU  - Chalmers,JD
AU  - Sridhar,S
AU  - Ritchie,AI
AU  - Lalvani,A
AU  - Wickremasinghe,M
AU  - Kon,OM
DO  - 10.5588/ijtld.16.0159
EP  - 1660
PY  - 2016///
SN  - 1815-7920
SP  - 1653
TI  - Evaluation of serum inflammatory biomarkers as predictors of treatment outcome in pulmonary tuberculosis
T2  - International Journal of Tuberculosis and Lung Disease
UR  - http://dx.doi.org/10.5588/ijtld.16.0159
VL  - 20
ER  -
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