Imperial College London
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PROFESSOR AJIT LALVANI

Faculty of Medicine, National Heart & Lung Institute

Chair in Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 0883a.lalvani

 
 
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Assistant

 

Dr Luis Berrocal Almanza +44 (0)20 7594 3721

 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Singanayagam:2017:10.1016/S1473-3099(17)30360-2,
author = {Singanayagam, A and Zambon, M and Lalvani, A and Barclay, W},
doi = {10.1016/S1473-3099(17)30360-2},
journal = {Lancet Infectious Diseases},
pages = {e25--e32},
title = {Urgent challenges in implementing live attenuated influenza vaccine.},
url = {http://dx.doi.org/10.1016/S1473-3099(17)30360-2},
volume = {18},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Conflicting reports have emerged about the effectiveness of the live attenuated influenza vaccine. The live attenuated influenza vaccine appears to protect particularly poorly against currently circulating H1N1 viruses that are derived from the 2009 pandemic H1N1 viruses. During the 2015-16 influenza season, when pandemic H1N1 was the predominant virus, studies from the USA reported a complete lack of effectiveness of the live vaccine in children. This finding led to a crucial decision in the USA to recommend that the live vaccine not be used in 2016-17 and to switch to the inactivated influenza vaccine. Other countries, including the UK, Canada, and Finland, however, have continued to recommend the use of the live vaccine. This policy divergence and uncertainty has far reaching implications for the entire global community, given the importance of the production capabilities of the live attenuated influenza vaccine for pandemic preparedness. In this Personal View, we discuss possible explanations for the observed reduced effectiveness of the live attenuated influenza vaccine and highlight the underpinning scientific questions. Further research to understand the reasons for these observations is essential to enable informed public health policy and commercial decisions about vaccine production and development in coming years.
AU  - Singanayagam,A
AU  - Zambon,M
AU  - Lalvani,A
AU  - Barclay,W
DO  - 10.1016/S1473-3099(17)30360-2
EP  - 32
PY  - 2017///
SN  - 1473-3099
SP  - 25
TI  - Urgent challenges in implementing live attenuated influenza vaccine.
T2  - Lancet Infectious Diseases
UR  - http://dx.doi.org/10.1016/S1473-3099(17)30360-2
UR  - http://hdl.handle.net/10044/1/51902
VL  - 18
ER  -
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