Dr. Alexander R.M. Lyons, Ph.D

Summary

Research Associate managing the global operations of a multinational clinical database (EAS FHSC Registry ct.gov ID: NCT04272697) of over 70K patients across 75 countries and contributing to its epidemiological studies in familial hypercholesterolaemia (THE LANCET 2021, 2022, 2023; DIGITAL HEALTH; IHJ; EAJ) and sustainability via multimillion-pound/dollar industry grants (Ultragenyx; Regeneron; Daiichi-Sankyo).

The impact of our worldwide collaborative research is expected to empower the medical and global communities to seek changes in countries and organisations regarding how familial hypercholesterolaemia is detected and managed, with a view to promoting early diagnosis and more effective treatment of this condition. Our outputs have been used to leverage healthcare policy lobbying at international levels with senior European policy makers.

External Advisor to the Lipid Registry of Africa (LIPRA).

Publications

Lyons ARM, Stevens CAT, Dharmayat KI, Vallejo-Vaz AJ, Ray KK. Opinion Paper. Overview of a collaborative global effort to address the burden of familial hypercholesterolaemia. INDIAN HEART JOURNAL 2023; Published online 18^th November 2023. doi/org/10.1016/j.ihj.2023.11.005

Dharmayat KI, Vallejo-Vaz AJ, Stevens CAT, Brandts J, Lyons ARM, Groselj U, AbiFadel M, Aguilar-Salinas CA, Alhabib K, Alkhnifsawi M, Almahmeed W, Alnouri F, Alonso R, Al-Rasadi K, Ashavaid TF, Banach M, Béliard S, Binder C, Bourbon M, Chlebus K, Corral P, Descamps OS, Drogari E, Durst R, Ezhov MV, Genest J, Harada-Shiba M, Holven KB, Humphries SE, Lalic K, Laufs U, Liberopoulos E, van Lennep JR, Lin J, Lima-Martinez MM, Maher V, März W, Mitchenko O, Nawawi H, Paragh G, Postadzhiyan A, Reda A, Reiner Z, Reyes X, Sadiq F, Sahebkar A, Schunkert H, Shek AB, Stroes E, Su TC, Subramaniam T, Susekov A, Symeonides P, Cárdenas AV, Truong TH, Vohnout B, Wang L, Weerapan K, Yamashita S, Al-Sarraf A, Al-Sayed N, Davletov K, Dwiputra B, Gaita D, Kayikcioglu M, Latkovskis G, Marais D, Matthias AT, Mirrakhimov E, Nordestgaard BG, Petrulioniene Z, Pojskic B, Sadoh W, Tilney M, Tomlinson B, Tybjærg-Hansen A, Viigimaa M, Catapano AL, Freiberger T, Hovingh GK, Mata P, Soran H, Raal F, Watts GF, Santos R, Ray KK, on behalf of EAS FHSC. Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study. THE LANCET; Published online 12^th December 2023. doi.org/10.1016/S0140-6736(23)01842-1

Stevens CAT, Lyons ARM, Dharmayat KI, Mahani A, Ray KK, Vallejo-Vaz AJ, Sharabiani M. Ensemble Machine Learning Methods in Screening Electronic Health Records: A Scoping Review. DIGITAL HEALTH 2023; May 9;9:20552076231173225. doi.org/10.1177/20552076231173225

Stevens CAT, Lyons ARM, Dharmayat KI, Brandts JM, Vallejo-Vaz AJ, Daccord M, Ray KK. FindMyLipidClinic.com: A global Directory of lipid clinics and patient organisations to improve dyslipidaemia care. EUROPEAN ATHEROSCLEROSIS JOURNAL 2022; 2:37-40. doi.org/10.56095/eaj.v1i2.11

Tromp TR, Hartgers ML, Hovingh GK, Vallejo-Vaz AJ, Ray KK, Soran H, Freiberger T, Bertolini S, Harada-Shiba M, Blom DJ, Raal FJ, Cuchel M, and the Homozygous Familial Hypercholesterolaemia International Clinical Collaborators: Tromp TR, Hartgers ML, Hovingh GK, Vallejo-Vaz AJ, Ray KK, Soran H, Freiberger T, Bertolini S, Harada-Shiba M, Pang J, Watts GF, Ebenbichler CF, Greber-Platzer S, Mäser M, Stulnig TM, Thani KB, Cassiman D, Descamps OS, Rymen D, Witters P, Santos RD, Brunham LR, Francis GA, Genest J, Hegele RA, Kennedy BA, Ruel I, Sherman MH, Jiang L, Wang L, Reiner Z, Blaha V, Ceska R, Dvorakova J, Dlouhy L, Horak P, Soska V, Tichy L, Urbanek R, Vaverkova H, Vrablik M, Zemek S, Zlatohlavek L, Emil S, Naguib T, Reda A, Béliard S, Bruckert E, Gallo A, Elisaf MS, Kolovou G, Cohen H, Durst R, Eldad DJ, Ellis A, Hussein O, Leitersdorf E, Schurr D, Setia N, Verma IC, Alareedh MD, Al-Khnifsawi M, Al-Zamili AF, Rhadi SB, Shaghee FK, Arca M, Averna M, Bartuli A, Bucci M, Buonuomo PS, Calabrò P, Calandra S, Casula M, Catapano AL, Cefalù AB, Cicero AF, D'Addato S, D'Erasmo L, Constanzo AD, Fasano T, Gazzotti M, Giammanco A, Iannuzzo G, Ibba A, Negri EA, Pasta A, Pavanello C, Pisciotta L, Rabacchi C, Ripoli C, Sampietro T, Sbrana F, Sileo F, Suppressa P, Tarugi P, Trenti C, Zenti M, Hori M, Ayesh MH, Azar ST, Bitar FF, Fahed AC, Moubarak EM, Nemer G, Nawawi H, Madriz R, Mehta R, Cupido AJ, Defesche JC, Reijman MD, Roeters-van Lennep JE, Stroes ES, Wiegman A, Zuurbier L, Al-Waili K, Sadiq F, Chlebus K, Bourbon M, Gaspar IM, Lalic KS, Ezhov MV, Susekov AV, Groselj U, Charng MJ, Khovidhunkit W, Aktan M, Altunkeser BB, Demircioglu S, Kose M, Gokce C, Ilhan O, Kayikcioglu M, Kaynar LG, Kuku I, Kurtoglu E, Okutan H, Ozcebe OI, Pekkolay Z, Sag S, Salcioglu OZ, Temizhan A, Yenercag M, Yilmaz M, Yasar HY, Mitchenko O, Lyons ARM, Stevens CAT, Brothers JA, Hudgins LC, Nguyen C, Alieva R, Shek A, Do DL, Kim NT, Le HA, Le TT, Nguyen MNT, Truong TH, Blom DJ, Raal FJ, Cuchel M. Worldwide experience of homozygous familial hypercholesterolaemia: retrospective cohort study. THE LANCET 2022; 399(10326): 719-728. doi.org/10.1016/S0140-6736(21)02001-8

Vallejo-Vaz AJ, Stevens CAT, Lyons ARM, Dharmayat KI, Freiberger T, Hovingh GK, Mata P, Raal FJ, Santos RD, Soran H, Watts GF, Abifadel M, Aguilar-Salinas CA, Alhabib KF, Alkhnifsawi M, Almahmeed W, Alnouri F, Alonso R, Al-Rasadi K, Al-Sarraf A, Al-Sayed N, Araujo F, Ashavaid TF, Banach M, Béliard S, Benn M, Binder CJ, Bogsrud MP, Bourbon M, Chlebus K, Corral P, Davletov K, Descamps OS, Durst R, Ezhov M, Gaita D, Genest J, Groselj U, Harada-Shiba M, Holven KB, Kayikcioglu M, Khovidhunkit W, Lalic K, Latkovskis G, Laufs U, Liberopoulos E, Lima-Martinez MM, Lin J, Maher V, Marais AD, März W, Mirrakhimov E, Miserez AR, Mitchenko O, Nawawi H, Nordestgaard BG, Panayiotou AG, Paragh G, Petrulioniene Z, Pojskic B, Postadzhiyan A, Raslova K, Reda A, Reiner Z, Sadiq F, Sadoh WE, Schunkert H, Shek AB, Stoll M, Stroes E, Su TC, Subramaniam T, Susekov AV, Tilney M, Tomlinson B, Truong TH, Tselepis AD, Tybjærg-Hansen A, Cárdenas AV, Viigimaa M, Wang L, Yamashita S, Tokgozoglu L, Catapano AL, Ray KK; on behalf of EAS FHSC. A global perspective on familial hypercholesterolaemia:  a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). THE LANCET 2021; 398(10312):1663-1776. doi.org/10.1016/S0140-6736(21)01122-3

Grants

Ultragenyx; Daiichi-Sankyo Europe; Regeneron

Publications

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