668 results found
Zunt JR, Kassebaum NJ, Blake N, et al., 2018, Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016, LANCET NEUROLOGY, Vol: 17, Pages: 1061-1082, ISSN: 1474-4422
Kyu HH, Abate D, Abate KH, et al., 2018, Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017, LANCET, Vol: 392, Pages: 1859-1922, ISSN: 0140-6736
James SLG, Abate D, Abate KH, et al., 2018, Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017, LANCET, Vol: 392, Pages: 1789-1858, ISSN: 0140-6736
Dicker D, Nguyen G, Abate D, et al., 2018, Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017, LANCET, Vol: 392, Pages: 1684-1735, ISSN: 0140-6736
Lozano R, Fullman N, Abate D, et al., 2018, Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017, LANCET, Vol: 392, Pages: 2091-2138, ISSN: 0140-6736
Murray CJL, Callender CSKH, Kulikoff XR, et al., 2018, Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017, LANCET, Vol: 392, Pages: 1995-2051, ISSN: 0140-6736
Stanaway JD, Afshin A, Gakidou E, et al., 2018, Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017, LANCET, Vol: 392, Pages: 1923-1994, ISSN: 0140-6736
Roth GA, Collaborotors GBDCD, Abate D, et al., 2018, Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017, LANCET, Vol: 392, Pages: 1736-1788, ISSN: 0140-6736
Steel N, Ford JA, Newton JN, et al., 2018, Changes in health in the countries of the UK and 150 English Local Authority areas 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016, LANCET, Vol: 392, Pages: 1647-1661, ISSN: 0140-6736
Fitzmaurice C, Akinyemiju TF, Al Lami FH, et al., 2018, Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 A Systematic Analysis for the Global Burden of Disease Study, JAMA ONCOLOGY, Vol: 4, Pages: 1553-1568, ISSN: 2374-2437
Shather Z, Laverty AA, Bottle A, et al., 2018, Sustained Socioeconomic Inequalities in Hospital Admissions for Cardiovascular Events Among People with Diabetes in England, AMERICAN JOURNAL OF MEDICINE, Vol: 131, Pages: 1340-1348, ISSN: 0002-9343
Alexakis C, Saxena S, Chhaya V, et al., 2018, Smoking Status at Diagnosis and Subsequent Smoking Cessation: Associations With Corticosteroid Use and Intestinal Resection in Crohn's Disease., Am J Gastroenterol, Vol: 113, Pages: 1689-1700
BACKGROUND: The impact of smoking at diagnosis and subsequent smoking cessation on clinical outcomes in Crohn's disease (CD) has not been evaluated in a population-based cohort. METHODS: Using a nationally representative clinical research database, we identified incident cases of CD between 2005 and 2014. We compared the following outcomes: overall corticosteroid (CS) use; flares requiring CS; CS dependency and intestinal surgery between smokers and non-smokers at time of CD diagnosis. Differences in these outcomes were also compared between persistent smokers and smokers who quit within 2 years of diagnosis. RESULTS: We identified 3553 patients with a new CD diagnosis over the study period of whom 1121 (32%) were smokers. Smokers at CD diagnosis had significantly higher CS-use (56 versus 47%, p < 0.0001), proportionally more CS flares (>1 CS flare/year: 9 versus 6%, p < 0.0001), and higher CS dependency (27 versus 21%, p < 0.0001) than non-smokers. Regression analysis identified smoking at diagnosis to be associated with a higher risk of intestinal surgery (HR 1.64, 95% CI 1.16-2.52). There was a significantly higher proportion of 'quitters' who remained steroid-free through follow-up in comparison to 'persistent smokers' (45.4 versus 37.5%, respectively, p = 0.02). 'Quitters' also had lower rates of CS dependency compared to 'persistent smokers' (24 versus 33%, p = 0.008). CONCLUSIONS: Smokers at CD diagnosis have higher CS-use, CS dependency and higher risk of intestinal surgery. Quitting smoking appears to have beneficial effects on disease related outcomes, including reducing CS dependency highlighting the importance of offering early smoking cessation support.
Elmontsri M, Banarsee R, Majeed A, 2018, Improving patient safety in developing countries - moving towards an integrated approach., JRSM Open, Vol: 9, ISSN: 2054-2704
Patient safety is a major public health issue. It has also been recognised as an area for improvement. The purpose of this article is to discuss the need for developing an integrated approach to patient safety improvement in developing countries. Relevant literature to identify the common themes and patterns associated with patient safety improvement was conducted through a search of the online databases (MEDLINE, EMBASE, PUBMED and Google Scholar) for the years 2000 to 2017. Lessons and interventions from developed countries have been taken into consideration to identify the themes needed for patient safety improvement in developing countries. This review provides an integrated approach based on best practice which can be used to guide the development of a national strategy for improving patient safety. Policy makers need to focus on developing a holistic and comprehensive approach to patient safety improvement that takes into account the themes discussed in this article.
Hayhoe B, Cowling TE, Pillutla V, et al., 2018, Integrating a nationally scaled workforce of community health workers in primary care: a modelling study., J R Soc Med
Objective To model cost and benefit of a national community health worker workforce. Design Modelling exercise based on all general practices in England. Setting United Kingdom National Health Service Primary Care. Participants Not applicable. Data sources Publicly available data on general practice demographics, population density, household size, salary scales and screening and immunisation uptake. Main outcome measures We estimated numbers of community health workers needed, anticipated workload and likely benefits to patients. Results Conservative modelling suggests that 110,585 community health workers would be needed to cover the general practice registered population in England, costing £2.22bn annually. Assuming community health workerss could engage with and successfully refer 20% of eligible unscreened or unimmunised individuals, an additional 753,592 cervical cancer screenings, 365,166 breast cancer screenings and 482,924 bowel cancer screenings could be expected within respective review periods. A total of 16,398 additional children annually could receive their MMR1 at 12 months and 24,716 their MMR2 at five years of age. Community health workerss would also provide home-based health promotion and lifestyle support to patients with chronic disease. Conclusion A scaled community health worker workforce integrated into primary care may be a valuable policy alternative. Pilot studies are required to establish feasibility and impact in NHS primary care.
Chang KC-M, Vamos EP, Palladino R, et al., 2018, Impact of the NHS Health Check on inequalities in cardiovascular disease risk: a difference-in-differences matching analysis., J Epidemiol Community Health
BACKGROUND: We assessed impacts of a large, nationwide cardiovascular disease (CVD) risk assessment and management programme on sociodemographic group inequalities in (1) early identification of hypertension, type 2 diabetes (T2D) and chronic kidney disease (CKD); and (2) management of global CVD risk among high-risk individuals. METHODS: We obtained retrospective electronic medical records from the Clinical Practice Research Datalink for a randomly selected sample of 138 788 patients aged 40-74 years without known CVD or diabetes, who were registered with 462 practices between 2009 and 2013. We estimated programme impact using a difference-in-differences matching analysis that compared changes in outcome over time between attendees and non-attendees. RESULTS: National Health Service Health Check attendance was 21.4% (29 672/138 788). A significantly greater number of hypertension and T2D incident cases were identified in men than women (eg, an additional 4.02%, 95% CI 3.65% to 4.39%, and 2.08%, 1.81% to 2.35% cases of hypertension in men and women, respectively). A significantly greater number of T2D incident cases were identified among attendees living in the most deprived areas, but no differences were found for hypertension and CKD across socioeconomic groups. No major differences in CVD risk management were observed between sociodemographic subgroups (eg, programme impact on 10-year CVD risk score was -1.13%, -1.48% to -0.78% in male and -1.53%, -2.36% to -0.71% in female attendees). CONCLUSION: During 2009-2013, the programme had low attendance and small overall impacts on early identification of disease and risk management. The age, sex and socioeconomic subgroups appeared to have derived similar level of benefits, leaving existing inequalities unchanged. These findings highlight the importance of population-wide interventions to address inequalities in CVD outcomes.
Vamos E, Shather Z, Laverty A, et al., 2018, Socio-economic inequalities in hospital admissions for major cardiovascular events in people with diabetes in England, 54th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S576-S576, ISSN: 0012-186X
Griswold MG, Fullman N, Hawley C, et al., 2018, Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016, LANCET, Vol: 392, Pages: 1015-1035, ISSN: 0140-6736
Thomson H, Oliver N, Godsland IF, et al., 2018, Protocol for a clinical trial of text messaging in addition to standard care versus standard care alone in prevention of type 2 diabetes through lifestyle modification in India and the UK, BMC ENDOCRINE DISORDERS, Vol: 18, ISSN: 1472-6823
Hayhoe B, Butler CC, Majeed A, et al., 2018, Telling the truth about antibiotics: benefits, harms and moral duty in prescribing for children in primary care, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 73, Pages: 2298-2304, ISSN: 0305-7453
Alturkistani A, Majeed A, Car J, et al., 2018, Health information technology uses for primary prevention in preventive medicine: a scoping review protocol, BMJ OPEN, Vol: 8, ISSN: 2044-6055
Shaikhan F, Rawaf S, Majeed A, et al., 2018, Knowledge, attitude, perception and practice regarding antimicrobial use in upper respiratory tract infections in Qatar: a systematic review., JRSM Open, Vol: 9, ISSN: 2054-2704
Objective: To explore the knowledge, attitude, perception and practice towards antimicrobial use in upper respiratory tract infections in patients visiting healthcare settings in Qatar. Design: Systematic review was performed using a predetermined protocol and in accordance with standardized reporting guidelines. MEDLINE, PubMed, EMBASE, Global Health and PsycINFO were searched for relevant published studies using relevant MESH terms and keywords. Setting: All healthcare settings in Qatar including both inpatient and ambulatory care. Participants: All published articles exploring the antimicrobial use in upper respiratory tract infections at any health setting in Qatar were considered for inclusion in the study. No age, gender or population were excluded. Main Outcome Measures: The outcome of interest was antimicrobial use in upper respiratory tract infections in Qatar. We included all related studies to explore the knowledge, attitude, perception and practice for patients visiting all health care settings. Results: Three articles were included, one in a primary care setting, one in a secondary care setting and one in the private sector. Overprescribing was noted in all settings. Our findings demonstrate low expectations to receive antibiotics, among the Qatari population, in primary care (28.1%). In fact, the majority of patients would be satisfied with reassurance rather than receiving antimicrobials. Many patients were satisfied with explanation from physicians and counselling. Private sector registered high prevalence of antimicrobial misuse for respiratory tract infections in which 85% deemed inappropriate. This finding was also noted at a medical intensive care unit which showed high antimicrobial use (76%) and respiratory tract infections accounted for 57% of prescriptions. Conclusion: Studies are needed to determine factors and population-based rates of antimicrobial use in all healthcare settings. There is also a need for interventional programs for both ph
Cowling TE, Majeed A, Harris MJ, 2018, Patient experience of general practice and use of emergency hospital services in England: regression analysis of national cross-sectional time series data, BMJ QUALITY & SAFETY, Vol: 27, Pages: 643-654, ISSN: 2044-5415
Balinskaite V, Bottle A, Shaw LJ, et al., 2018, Reorganisation of stroke care and impact on mortality in patients admitted during weekends: a national descriptive study based on administrative data, BMJ QUALITY & SAFETY, Vol: 27, Pages: 611-618, ISSN: 2044-5415
Majeed A, Allwood D, Foley K, et al., 2018, Healthcare outcomes and quality in the NHS: how do we compare and how might the NHS improve?, BMJ-BRITISH MEDICAL JOURNAL, Vol: 362, ISSN: 1756-1833
Cowling TE, Majeed A, Harris MJ, 2018, Importance of accessibility and opening hours to overall patient experience of general practice: analysis of repeated cross-sectional data from a national patient survey, BRITISH JOURNAL OF GENERAL PRACTICE, Vol: 68, Pages: E469-E477, ISSN: 0960-1643
Tudor Car L, Riboli-Sasco EF, Marcano Belisario JS, et al., 2018, Mobile learning for delivering health professional education, Cochrane Database of Systematic Reviews, ISSN: 1469-493X
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The objective of this review is to evaluate the effectiveness of mLearning educational interventions for delivering pre-registration and post-registration healthcare professional education. We will primarily assess the impact of these interventions on students' knowledge, skills, professional attitudes and satisfaction.
Fullman N, Yearwood J, Abay SM, et al., 2018, Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016, LANCET, Vol: 391, Pages: 2236-2271, ISSN: 0140-6736
Owusu ESA, Samanta M, Shaw JE, et al., 2018, Weight loss and mortality risk in patients with different adiposity at diagnosis of type 2 diabetes: a longitudinal cohort study, NUTRITION & DIABETES, Vol: 8, ISSN: 2044-4052
Jewell P, Majeed A, 2018, The F3 year: why increasing numbers of foundation programme doctors are deciding against specialty training programmes and its implications for the National Health Service, Journal of the Royal Society of Medicine, Pages: 1-3, ISSN: 1758-1095
Hargreaves S, Nellums LB, Ramsay M, et al., 2018, Who is responsible for the vaccination of migrants in Europe?, LANCET, Vol: 391, Pages: 1752-1754, ISSN: 0140-6736
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