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@article{Beghi:2019:10.1016/S1474-4422(18)30454-X,
author = {Beghi, E and Giussani, G and Abd-Allah, F and Abdela, J and Abdelalim, A and Abraha, HN and Adib, MG and Agrawal, S and Alandab, F and Awasthi, A and Ayele, Y and Barboza, MA and Belachew, AB and Biadgo, B and Bijani, A and Bitew, H and Carvalho, F and Chaiah, Y and Daryani, A and Huyen, PD and Dubey, M and Endries, AYY and Eskandarieh, S and Faro, A and Farzadfar, F and Fereshtehnejad, S-M and Fernandes, E and Fijabi, DO and Filip, I and Fischer, F and Gebre, AK and Tsadik, AG and Gebremichael, TG and Gezae, KE and Ghasemi-Kasman, M and Weldegwergs, KG and Degefa, MG and Gnedovskaya, E and Hagos, TB and Haj-Mirzaian, A and Haj-Mirzaian, A and Hassen, HY and Hay, S and Jakovljevic, M and Kasaeian, A and Kassa, TD and Khader, YS and Khalil, I and Khan, EA and Khubchandani, J and Kisa, A and Krohn, KJ and Kulkarni, C and Nirayo, YL and Mackay, MT and Majdan, M and Majeed, A and Manhertz, T and Mehndiratta, MM and Mekonen, T and Meles, HG and Mengistu, G and Mohammed, S and Naghavi, M and},
doi = {10.1016/S1474-4422(18)30454-X},
journal = {Lancet Neurology},
pages = {357--375},
title = {Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016},
url = {http://dx.doi.org/10.1016/S1474-4422(18)30454-X},
volume = {18},
year = {2019}
}

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TY  - JOUR
AB  - BackgroundSeizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and location using data from the Global Burden of Diseases, Injuries, and Risk Factors Study.MethodsWe assessed the burden of epilepsy in 195 countries and territories from 1990 to 2016. Burden was measured as deaths, prevalence, and disability-adjusted life-years (DALYs; a summary measure of health loss defined by the sum of years of life lost [YLLs] for premature mortality and years lived with disability), by age, sex, year, location, and Socio-demographic Index (SDI; a compound measure of income per capita, education, and fertility). Vital registrations and verbal autopsies provided information about deaths, and data on the prevalence and severity of epilepsy largely came from population representative surveys. All estimates were calculated with 95% uncertainty intervals (UIs).FindingsIn 2016, there were 45·9 million (95% UI 39·9–54·6) patients with all-active epilepsy (both idiopathic and secondary epilepsy globally; age-standardised prevalence 621·5 per 100000 population; 540·1–737·0). Of these patients, 24·0 million (20·4–27·7) had active idiopathic epilepsy (prevalence 326·7 per 100000 population; 278·4–378·1). Prevalence of active epilepsy increased with age, with peaks at 5–9 years (374·8 [280·1–490·0]) and at older than 80 years of age (545·1 [444·2–652·0]). Age-standardised prevalence of active idiopathic epilepsy was 329·3 per 100000 population (280·3–381·2) in men and 318·9 per 100000 population (271·1–369&
AU  - Beghi,E
AU  - Giussani,G
AU  - Abd-Allah,F
AU  - Abdela,J
AU  - Abdelalim,A
AU  - Abraha,HN
AU  - Adib,MG
AU  - Agrawal,S
AU  - Alandab,F
AU  - Awasthi,A
AU  - Ayele,Y
AU  - Barboza,MA
AU  - Belachew,AB
AU  - Biadgo,B
AU  - Bijani,A
AU  - Bitew,H
AU  - Carvalho,F
AU  - Chaiah,Y
AU  - Daryani,A
AU  - Huyen,PD
AU  - Dubey,M
AU  - Endries,AYY
AU  - Eskandarieh,S
AU  - Faro,A
AU  - Farzadfar,F
AU  - Fereshtehnejad,S-M
AU  - Fernandes,E
AU  - Fijabi,DO
AU  - Filip,I
AU  - Fischer,F
AU  - Gebre,AK
AU  - Tsadik,AG
AU  - Gebremichael,TG
AU  - Gezae,KE
AU  - Ghasemi-Kasman,M
AU  - Weldegwergs,KG
AU  - Degefa,MG
AU  - Gnedovskaya,E
AU  - Hagos,TB
AU  - Haj-Mirzaian,A
AU  - Haj-Mirzaian,A
AU  - Hassen,HY
AU  - Hay,S
AU  - Jakovljevic,M
AU  - Kasaeian,A
AU  - Kassa,TD
AU  - Khader,YS
AU  - Khalil,I
AU  - Khan,EA
AU  - Khubchandani,J
AU  - Kisa,A
AU  - Krohn,KJ
AU  - Kulkarni,C
AU  - Nirayo,YL
AU  - Mackay,MT
AU  - Majdan,M
AU  - Majeed,A
AU  - Manhertz,T
AU  - Mehndiratta,MM
AU  - Mekonen,T
AU  - Meles,HG
AU  - Mengistu,G
AU  - Mohammed,S
AU  - Naghavi,M
AU  - Mokdad,AH
AU  - Mustafa,G
AU  - Irvani,SSN
AU  - Long,HN
AU  - Nichols,E
AU  - Nixon,MR
AU  - Ogbo,FA
AU  - Olagunju,AT
AU  - Olagunju,TO
AU  - Owolabi,MO
AU  - Philips,MR
AU  - Pinilla-Monsalve,GD
AU  - Qorbani,M
AU  - Radfar,A
AU  - Rafay,A
AU  - Rahimi-Movaghar,V
AU  - Reinig,N
AU  - Sachdev,PS
AU  - Safari,H
AU  - Safari,S
AU  - Safiri,S
AU  - Sahraian,MA
AU  - Samy,AM
AU  - Sarvi,S
AU  - Sawhney,M
AU  - Shaikh,MA
AU  - Sharif,M
AU  - Singh,G
AU  - Smith,M
AU  - Szoeke,CE
AU  - Tabares-Seisdedos,R
AU  - Temsah,M-H
AU  - Temsah,O
AU  - Tortajada-Girbes,M
AU  - Bach,XT
AU  - Tsegay,AAT
AU  - Ullah,I
AU  - Venketasubramanian,N
AU  - Westerman,R
AU  - Winkler,AS
AU  - Yimer,EM
AU  - Yonemoto,N
AU  - Feigin,VL
AU  - Vos,T
AU  - Murray,CJL
DO  - 10.1016/S1474-4422(18)30454-X
EP  - 375
PY  - 2019///
SN  - 1474-4422
SP  - 357
TI  - Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
T2  - Lancet Neurology
UR  - http://dx.doi.org/10.1016/S1474-4422(18)30454-X
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000461169400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/68169
VL  - 18
ER  -

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