Imperial College London

Athanasios Mantalaris, PhD

Faculty of EngineeringDepartment of Chemical Engineering

Professor in Biosystems Engineering
 
 
 
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Contact

 

+44 (0)20 7594 5601a.mantalaris Website

 
 
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Assistant

 

Mrs Sarah Payne +44 (0)20 7594 5567

 
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Location

 

515ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

234 results found

Kang Y, Georgiou AI, MacFarlane RJ, Klontzas ME, Heliotis M, Tsiridis E, Mantalaris Aet al., 2017, Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol: 11, Pages: 1929-1940, ISSN: 1932-6254

JOURNAL ARTICLE

Tsipa A, Koutinas M, Vernardis SI, Mantalaris Aet al., 2017, The impact of succinate trace on pWW0 and ortho-cleavage pathway transcription in Pseudomonas putida mt-2 during toluene biodegradation, BIORESOURCE TECHNOLOGY, Vol: 234, Pages: 397-405, ISSN: 0960-8524

JOURNAL ARTICLE

Fauzi I, Panoskaltsis N, Mantalaris A, 2016, In Vitro Differentiation of Embryonic Stem Cells into Hematopoietic Lineage: Towards Erythroid Progenitor's Production., Methods Mol Biol, Vol: 1341, Pages: 217-234

Embryonic stem cells (ESCs) differentiation via embryoid body (EB) formation is an established method that generates the three germ layers. However, EB differentiation poses several problems including formation of heterogeneous cell populations. Herein, we described a differentiation protocol on enhancing mesoderm derivation from murine ESCs (mESCs) using conditioned medium (CM) from HepG2 cells. We used this technique to direct hematopoiesis by generating "embryoid-like" colonies (ELCs) from murine (m) ESCs without following standard formation of EBs. Our CM-mESCs group yielded an almost fivefold increase in ELC formation (p ≤ 0.05) and higher expression of mesoderm genes;-Brachyury-T, Goosecoid, and Flk-1 compared with control mESCs group. Hematopoietic colony formation from CM-mESCs was also enhanced by twofold at days 7 and 14 with earlier colony commitment compared to control mESCs (p ≤ 0.05). This early clonogenic capacity was confirmed morphologically by the presence of nucleated erythrocytes and macrophages as early as day 7 in culture using standard 14-day colony-forming assay. Early expression of hematopoietic primitive (ζ-globin) and definitive (β-globin) erythroid genes and proteins was also observed by day 7 in the CM-treated culture. These data indicate that hematopoietic cells more quickly differentiate from CM-treated, compared with those using standard EB approaches, and provide an efficient bioprocess platform for erythroid-specific differentiation of ESCs.

JOURNAL ARTICLE

Klontzas ME, Kenanidis EI, MacFarlane RJ, Michail T, Potoupnis ME, Heliotis M, Mantalaris A, Tsiridis Eet al., 2016, Investigational drugs for fracture healing: preclinical & clinical data, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 25, Pages: 585-596, ISSN: 1354-3784

JOURNAL ARTICLE

Kostoglou M, Fuentes-Gari M, Garcia-Munzer D, Georgiadis MC, Panoskaltsis N, Pistikopoulos EN, Mantalaris Aet al., 2016, A comprehensive mathematical analysis of a novel multistage population balance model for cell proliferation, COMPUTERS & CHEMICAL ENGINEERING, Vol: 91, Pages: 157-166, ISSN: 0098-1354

JOURNAL ARTICLE

Papathanasiou MM, Avraamidou S, Oberdieck R, Mantalaris A, Steinebach F, Morbidelli M, Mueller-Spaeth T, Pistikopoulos ENet al., 2016, Advanced Control Strategies for the Multicolumn Countercurrent Solvent Gradient Purification Process, AICHE JOURNAL, Vol: 62, Pages: 2341-2357, ISSN: 0001-1541

JOURNAL ARTICLE

Reissis D, Quen OT, Cooper NC, Carasco CF, Gamie Z, Mantalaris A, Tsiridis Eet al., 2016, Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair, EXPERT OPINION ON BIOLOGICAL THERAPY, Vol: 16, Pages: 535-557, ISSN: 1471-2598

JOURNAL ARTICLE

Savvopoulos S, Misener R, Panoskaltsis N, Pistikopoulos EN, Mantalaris Aet al., 2016, A Personalized Framework for Dynamic Modeling of Disease Trajectories in Chronic Lymphocytic Leukemia, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol: 63, Pages: 2396-2404, ISSN: 0018-9294

JOURNAL ARTICLE

Severn CE, Macedo H, Eagle MJ, Rooney P, Mantalaris A, Toye AMet al., 2016, Polyurethane scaffolds seeded with CD34(+) cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Tsipa A, Koutinas M, Pistikopoulos EN, Mantalaris Aet al., 2016, Transcriptional kinetics of the cross-talk between the ortho-cleavage and TOL pathways of toluene biodegradation in Pseudomonas putida mt-2, JOURNAL OF BIOTECHNOLOGY, Vol: 228, Pages: 112-123, ISSN: 0168-1656

JOURNAL ARTICLE

Zubairi SI, Mantalaris A, Bismarck A, Aizad Set al., 2016, POLYHYDROXYALKANOATES (PHAs) FOR TISSUE ENGINEERING APPLICATIONS: BIOTRANSFORMATION OF PALM OIL MILL EFFLUENT (POME) TO VALUE-ADDED POLYMERS, JURNAL TEKNOLOGI, Vol: 78, Pages: 13-29, ISSN: 0127-9696

JOURNAL ARTICLE

Allenby MC, Tahlawi A, Dos Santos SB, Misener R, Hwang Y, Panoskaltsis N, Mantalaris Aet al., 2015, Development of a Hematopoietic Microenvironment for the Production of Red Blood Cells (RBCs) in a Novel 3D Hollow Fibre Bioreactor, TISSUE ENGINEERING PART A, Vol: 21, Pages: S15-S16, ISSN: 1937-3341

JOURNAL ARTICLE

Allenby MC, Tahlawi A, dos Santos SB, Misener R, Hwang Y-S, Panoskaltsis N, Mantalaris Aet al., 2015, DEVELOPMENT OF AN EX VIVO BONE MARROW MIMICRY MICROENVIRONMENT IN A NOVEL 3D HOLLOW FIBRE BIOREACTOR, 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Publisher: ELSEVIER SCIENCE INC, Pages: S51-S51, ISSN: 0301-472X

CONFERENCE PAPER

Fuentes-Gari M, Misener R, Garcia-Munzer D, Velliou E, Georgiadis MC, Kostoglou M, Pistikopoulos EN, Panoskaltsis N, Mantalaris Aet al., 2015, A mathematical model of subpopulation kinetics for the deconvolution of leukaemia heterogeneity, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689

JOURNAL ARTICLE

Fuentes-Gari M, Misener R, Georgiadis MC, Kostoglou M, Panoskaltsis N, Mantalaris A, Pistikopoulos ENet al., 2015, Selecting a Differential Equation Cell Cycle Model for Simulating Leukemia Treatment, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol: 54, Pages: 8847-8859, ISSN: 0888-5885

JOURNAL ARTICLE

Fuentes-Gari M, Misener R, Pefani E, Garcia-Muenzer D, Kostoglou M-G, Georgiadis MC, Panoskaltsis N, Pistikopoulos EN, Mantalaris Aet al., 2015, Cell cycle model selection for leukemia and its impact in chemotherapy outcomes, 12TH INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING AND 25TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, PT C, Vol: 37, Pages: 2159-2164, ISSN: 1570-7946

JOURNAL ARTICLE

Fuentes-Gari M, Velliou E, Misener R, Pefani E, Rende M, Panoskaltsis N, Mantalaris A, Pistikopoulos ENet al., 2015, A systematic framework for the design, simulation and optimization of personalized healthcare: Making and healing blood, COMPUTERS & CHEMICAL ENGINEERING, Vol: 81, Pages: 80-93, ISSN: 0098-1354

JOURNAL ARTICLE

Fuentes-Gari M, Zemenides S, Misener R, Georgiadis MC, Pistikopouios EN, Mantalaris A, Panoskaltsis Net al., 2015, Use of Mathematical Modelling Indicates That Patients Treated for Acute Myeloid Leukaemia (AML) Are Undertreated When Ideal Body Weight Is Used to Dose Chemotherapy, 57th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Fuentes-Gaŕ M, Misener R, Georgiadis MC, Kostoglou M, Panoskaltsis N, Pistikopoulos EN, Mantalaris Aet al., 2015, Chemotherapy optimization in Leukemia: Selecting the right mathematical models for the right biological processes, Pages: 534-539, ISSN: 1474-6670

© 2015, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved. Clinical chemotherapy dosage strategies for leukemia rely on weight/height calculations theoretically correlated to patient drug tolerance. However, over-and under-dosage still exist in clinical practice, which could be overcome by quantifying the actual fraction of cancer cells susceptible to be eradicated. In this work, we show how choosing models that are accurate enough in simulating the biological processes ultimately affecting drug efficacy is critical in order to disentangle patient to patient heterogeneity. Incorporating heterogeneity from measurable sources in such a manner brings us a step closer in our path towards the development of personalized rational therapies.

CONFERENCE PAPER

Kiparissides A, Pistikopoulos EN, Mantalaris A, 2015, On the Model-Based Optimization of Secreting Mammalian Cell (GS-NS0) Cultures, BIOTECHNOLOGY AND BIOENGINEERING, Vol: 112, Pages: 536-548, ISSN: 0006-3592

JOURNAL ARTICLE

Klontzas ME, Kenanidis EI, Heliotis M, Tsiridis E, Mantalaris Aet al., 2015, Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells, EXPERT OPINION ON BIOLOGICAL THERAPY, Vol: 15, Pages: 1541-1552, ISSN: 1471-2598

JOURNAL ARTICLE

Kostoglou M, Fuentes-Gari M, Garcia-Muenzer D, Georgiadis MC, Panoskaltsis N, Pistikopoulos EN, Mantalaris Aet al., 2015, Mathematical analysis of multistage population balances for cell growth and death, 12TH INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING AND 25TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, PT C, Vol: 37, Pages: 2105-2110, ISSN: 1570-7946

JOURNAL ARTICLE

Muenzer DGG, Ivarsson M, Usaku C, Habicher T, Soos M, Morbidelli M, Pistikopoulos EN, Mantalaris Aet al., 2015, An unstructured model of metabolic and temperature dependent cell cycle arrest in hybridoma batch and fed-batch cultures, BIOCHEMICAL ENGINEERING JOURNAL, Vol: 93, Pages: 260-273, ISSN: 1369-703X

JOURNAL ARTICLE

Muenzer DGG, Kostoglou M, Georgiadis MC, Pistikopoulos EN, Mantalaris Aet al., 2015, Cyclin and DNA Distributed Cell Cycle Model for GS-NS0 Cells, PLOS COMPUTATIONAL BIOLOGY, Vol: 11, ISSN: 1553-734X

JOURNAL ARTICLE

Papathanasiou MM, Steinebach F, Stroehlein G, Mueller-Spaeth T, Nascu I, Oberdieck R, Morbidelli M, Mantalaris A, Pistikopoulos ENet al., 2015, A control strategy for periodic systems - application to the twin-column MCSGP, 12th International Symposium on Process Systems Engineering (PSE) / 25th European Symposium on Computer Aided Process Engineering (ESCAPE), Publisher: ELSEVIER SCIENCE BV, Pages: 1505-1510, ISSN: 1570-7946

CONFERENCE PAPER

Savvopoulos S, Misener R, Panoskaltsis N, Pistikopoulos EN, Mantalaris Aet al., 2015, Global Sensitivity Analysis for a Model of B-Cell Chronic Lymphocytic Leukemia Disease Trajectories, 12TH INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING (PSE) AND 25TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING (ESCAPE), PT A, Vol: 37, Pages: 185-190, ISSN: 1570-7946

JOURNAL ARTICLE

Velliou EG, Dos Santos SB, Papathanasiou MM, Fuentes-Gari M, Misener R, Panoskaltsis N, Pistikopoulos EN, Mantalaris Aet al., 2015, Towards unravelling the kinetics of an acute myeloid leukaemia model system under oxidative and starvation stress: a comparison between two- and three-dimensional cultures, BIOPROCESS AND BIOSYSTEMS ENGINEERING, Vol: 38, Pages: 1589-1600, ISSN: 1615-7591

JOURNAL ARTICLE

Zavitsanou S, Mantalaris A, Georgiadis MC, Pistikopoulos ENet al., 2015, In Silico Closed-Loop Control Validation Studies for Optimal Insulin Delivery in Type 1 Diabetes, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol: 62, Pages: 2369-2378, ISSN: 0018-9294

JOURNAL ARTICLE

Zubairi SI, Bismarck A, Mantalaris A, 2015, THE EFFECT OF SURFACE HETEROGENEITY ON WETTABILITY OF POROUS THREE DIMENSIONAL (3-D) SCAFFOLDS OF POLY(3-HYDROXYBUTYRIC ACID) (PHB) AND POLY(3-HYDROXYBUTYRIC-CO-3-HYDROXYVALERIC ACID) (PHBV), JURNAL TEKNOLOGI, Vol: 75, Pages: 305-312, ISSN: 0127-9696

JOURNAL ARTICLE

Zubairi SI, Mantalaris A, Bismarck A, 2015, Pore Interconnectivity Analysis of Porous Three Dimensional Scaffolds of Poly (3-Hydroxybutyric Acid) (PHB) and Poly(3-Hydroxybutyric-co-3-Hydroxyvaleric Acid) (PHBV) Through Non-Invasive Color Staining Method, SAINS MALAYSIANA, Vol: 44, Pages: 1351-1356, ISSN: 0126-6039

JOURNAL ARTICLE

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