Imperial College London
Alternate

Dr Aida Martinez-Sanchez

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3366a.martinez-sanchez Website

 
 
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Location

 

326ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Martinez-Sanchez:2017:10.3389/fgene.2016.00226,
author = {Martinez-Sanchez, A and Rutter, GA and Latreille, M},
doi = {10.3389/fgene.2016.00226},
journal = {Frontiers in Genetics},
title = {MiRNAs in β-Cell development, identity, and disease.},
url = {http://dx.doi.org/10.3389/fgene.2016.00226},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pancreatic β-cells regulate glucose metabolism by secreting insulin, which in turn stimulates the utilization or storage of the sugar by peripheral tissues. Insulin insufficiency and a prolonged period of insulin resistance are usually the core components of type 2 diabetes (T2D). Although, decreased insulin levels in T2D have long been attributed to a decrease in β-cell function and/or mass, this model has recently been refined with the recognition that a loss of β-cell "identity" and dedifferentiation also contribute to the decline in insulin production. MicroRNAs (miRNAs) are key regulatory molecules that display tissue-specific expression patterns and maintain the differentiated state of somatic cells. During the past few years, great strides have been made in understanding how miRNA circuits impact β-cell identity. Here, we review current knowledge on the role of miRNAs in regulating the acquisition of the β-cell fate during development and in maintaining mature β-cell identity and function during stress situations such as obesity, pregnancy, aging, or diabetes. We also discuss how miRNA function could be harnessed to improve our ability to generate β-cells for replacement therapy for T2D.
AU  - Martinez-Sanchez,A
AU  - Rutter,GA
AU  - Latreille,M
DO  - 10.3389/fgene.2016.00226
PY  - 2017///
SN  - 1664-8021
TI  - MiRNAs in β-Cell development, identity, and disease.
T2  - Frontiers in Genetics
UR  - http://dx.doi.org/10.3389/fgene.2016.00226
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28123396
UR  - http://hdl.handle.net/10044/1/44855
VL  - 7
ER  -
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