My group is based at the MRC Centre for Molecular Bacteriology & Infection in South Kensington. We study the role of innate immune receptors in the generation and modulation of innate immune responses in host immunity and inflammation, and how pathogens exploit these receptors to manipulate innate immune responses.
Phagocytic immune cells express a plethora of immune receptors to recognise, respond to and kill invading microbes. They also express inhibitory immune receptors that act to ensure that phagocytes do not damage the host by becoming activated in the wrong place or at the wrong time. Some receptors belong to families containing activating and inhibitory receptors, and these families are considered immunomodulatory receptors that act to generate balanced immune responses. These families include the CEACAM and LILR families of receptors, that are expressed on a range of innate and adaptive immune cell types. My laboratory studies the role of receptors from the CEACAM and LILR families in the biology of neutrophils, and how pathogens interact with these receptors to manipulate immune responses. Understanding the mechanisms that modulate innate immune cell activity, and how this is exploited by pathogens, could provide therapeutic approaches for infectious and inflammatory disease situations.
After completing a PhD at the University of Leeds, UK, I joined the laboratory of Prof Jodi Lindsay at St George's University of London, London, UK in 2008 to study the evolution and host-pathogen interactions of S. aureus. In 2013, I joined the laboratory of Prof Peter Taylor at University College London (UCL) School of Pharmacy, London, UK, to study the host-pathogen interactions of E. coli. I was awarded an Intra-European Fellowship for Career Development by EU MSCA to join the laboratory of Prof Jos van Strijp at the University Medical Centre (UMC) Utrecht in 2016 to study the role of LILRs on neutrophils. I am now a lecturer in innate immunity at the MRC Centre for Molecular Bacteriology of Infection at Imperial College London.
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McCarthy AJ, Birchenough GMH, Taylor PW, 2019, Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal Pathogen Escherichia coli K1, Infection and Immunity, Vol:87, ISSN:0019-9567
et al., 2018, Molecular basis determining species specificity for TLR2 inhibition by staphylococcal superantigen-like protein 3 (SSL3), Veterinary Research, Vol:49, ISSN:0928-4249
McCarthy AJ, Stabler RA, Taylor PW, 2018, Genome-Wide Identification by Transposon Insertion Sequencing of Escherichia coli K1 Genes Essential for In Vitro Growth, Gastrointestinal Colonizing Capacity, and Survival in Serum, Journal of Bacteriology, Vol:200, ISSN:0021-9193
et al., 2017, Immune evasion by a staphylococcal inhibitor of myeloperoxidase, Proceedings of the National Academy of Sciences, Vol:114, ISSN:0027-8424, Pages:9439-9444
et al., 2017, Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection, Scientific Reports, Vol:7, ISSN:2045-2322