Imperial College London
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ProfessorAlisonMcGregor

Faculty of Medicine, Department of Surgery & Cancer

Professor of Musculoskeletal Biodynamics
 
 
 
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Contact

 

+44 (0)20 7594 2972a.mcgregor

 
 
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Location

 

Room 202ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Henson:2021:10.1016/j.jbiomech.2021.110599,
author = {Henson, DP and Edgar, C and Ding, Z and Sivapuratharasu, B and Le, Feuvre P and Finnegan, ME and Quest, R and McGregor, AH and Bull, AMJ},
doi = {10.1016/j.jbiomech.2021.110599},
journal = {Journal of Biomechanics},
pages = {1--8},
title = {Understanding lower limb muscle volume adaptations to amputation.},
url = {http://dx.doi.org/10.1016/j.jbiomech.2021.110599},
volume = {125},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Amputation of a major limb, and the subsequent return to movement with a prosthesis, requires the development of compensatory strategies to account for the loss. Such strategies, over time, lead to regional muscle atrophy and hypertrophy through chronic under or overuse of muscles compared to uninjured individuals. The aim of this study was to quantify the lower limb muscle parameters of persons with transtibial and transfemoral amputations using high resolution MRI to ascertain muscle volume and to determine regression equations for predicting muscle volume using femur- and tibia-length, pelvic-width, height, and mass. Twelve persons with limb loss participated in this study and their data were compared to six matched control subjects. Subjects with unilateral transtibial amputation showed whole-limb muscle volume loss in the residual-limb, whereas minor volume changes in the intact limb were found, providing evidence for a compensation strategy that is dominated by the intact-limb. Subjects with bilateral-transfemoral amputations showed significant muscle volume increases in the short adductor muscles with an insertion not affected by the amputation, the hip flexors, and the gluteus medius, and significant volume decreases in the longer adductor muscles, rectus femoris, and hamstrings. This study presents a benchmark measure of muscle volume discrepancies in persons with limb-loss, and can be used to understand the compensation strategies of persons with limb-loss and the impact on muscle volume, thus enabling the development of optimised intervention protocols, conditioning therapies, surgical techniques, and prosthetic devices that promote and enhance functional capability within the population of persons with limb loss.
AU  - Henson,DP
AU  - Edgar,C
AU  - Ding,Z
AU  - Sivapuratharasu,B
AU  - Le,Feuvre P
AU  - Finnegan,ME
AU  - Quest,R
AU  - McGregor,AH
AU  - Bull,AMJ
DO  - 10.1016/j.jbiomech.2021.110599
EP  - 8
PY  - 2021///
SN  - 0021-9290
SP  - 1
TI  - Understanding lower limb muscle volume adaptations to amputation.
T2  - Journal of Biomechanics
UR  - http://dx.doi.org/10.1016/j.jbiomech.2021.110599
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34265657
UR  - https://www.sciencedirect.com/science/article/pii/S0021929021003766?via%3Dihub
UR  - http://hdl.handle.net/10044/1/90811
VL  - 125
ER  -
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