Imperial College London

ProfessorAlexandraPorter

Faculty of EngineeringDepartment of Materials

Professor of Bio-imaging and Analysis
 
 
 
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Contact

 

+44 (0)20 7594 9691a.porter

 
 
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Location

 

B341 Royal School of MinesRoyal School of MinesSouth Kensington Campus

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Summary

 

Summary

Alexandra's group uses correlative electron microscopy techniques to characterise interfaces between synthetic and natural bio / nanomaterials and cells and tissues  Her great interest is in developing a mechanistic understanding of how the physicochemistry of these materials controls their degradation behaviour, transformations and ultimate bioreactivity.  She uses this knowledge to guide improvement of materials performance and safety.   This interest stemmed from her PhD on application of electron microscopy (EM) to elucidate mechanisms by which silicon increases the quality of bone around hydroxyapatite implants.  She currently works on a number of systems, including the environmental fate and toxicology of nanomaterials  and how bone's quality and toughness become altered in pathological tissues.  She also designs new nanomaterials to cross the blood brain barrier and treat Parkinson's disease and for treatment of tuberculosis and breast cancers.

Alexandra holds and MEng from Oxford University, and a PhD from Cambridge University in Biomedical Materials.  She worked as a postdoctoral research fellow at the Lawrence Berkeley National Laboratory, MIT and The Nanoscience Centre Cambridge under the guidance of Sir Mark Welland and Prof. Paul Midgley.  She held the Oppenheimer Research fellowship for physical sciences at Cambridge University and a Junior Research Fellowship at Newhall College, Cambridge.

Selected Publications

Journal Articles

Porter AE, Gass M, Bendall JS, et al., 2009, Uptake of Noncytotoxic Acid-Treated Single-Walled Carbon Nanotubes into the Cytoplasm of Human Macrophage Cells, ACS Nano, Vol:3, ISSN:1936-0851, Pages:1485-1492

Muller KH, Kulkarni J, Motskin M, et al., 2010, pH-Dependent Toxicity of High Aspect Ratio ZnO Nanowires in Macrophages Due to Intracellular Dissolution, ACS Nano, Vol:4, ISSN:1936-0851, Pages:6767-6779

McGuire EK, Motskin M, Bolognesi B, et al., 2012, Selenium-Enhanced Electron Microscopic Imaging of Different Aggregate Forms of a Segment of the Amyloid beta Peptide in Cells, ACS Nano, Vol:6, ISSN:1936-0851, Pages:4740-4747

Boonrungsiman S, Gentleman E, Carzaniga R, et al., 2012, The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation, Proceedings of the National Academy of Sciences of the United States of America, Vol:109, ISSN:0027-8424, Pages:14170-14175

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