Imperial College London
Alternate

Professor Toby Prevost

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

a.prevost

 
 
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Location

 

57Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hollands:2016:10.1136/bmj.i1102,
author = {Hollands, GJ and French, DP and Griffin, SJ and Prevost, AT and Sutton, S and King, S and Marteau, TM},
doi = {10.1136/bmj.i1102},
journal = {BMJ},
title = {The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis},
url = {http://dx.doi.org/10.1136/bmj.i1102},
volume = {352},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective To assess the impact of communicating DNA based disease risk estimates on risk-reducing health behaviours and motivation to engage in such behaviours.Design Systematic review with meta-analysis, using Cochrane methods.Data sources Medline, Embase, PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials up to 25 February 2015. Backward and forward citation searches were also conducted.Study selection Randomised and quasi-randomised controlled trials involving adults in which one group received personalised DNA based estimates of disease risk for conditions where risk could be reduced by behaviour change. Eligible studies included a measure of risk-reducing behaviour.Results We examined 10 515 abstracts and included 18 studies that reported on seven behavioural outcomes, including smoking cessation (six studies; n=2663), diet (seven studies; n=1784), and physical activity (six studies; n=1704). Meta-analysis revealed no significant effects of communicating DNA based risk estimates on smoking cessation (odds ratio 0.92, 95% confidence interval 0.63 to 1.35, P=0.67), diet (standardised mean difference 0.12, 95% confidence interval −0.00 to 0.24, P=0.05), or physical activity (standardised mean difference −0.03, 95% confidence interval −0.13 to 0.08, P=0.62). There were also no effects on any other behaviours (alcohol use, medication use, sun protection behaviours, and attendance at screening or behavioural support programmes) or on motivation to change behaviour, and no adverse effects, such as depression and anxiety. Subgroup analyses provided no clear evidence that communication of a risk-conferring genotype affected behaviour more than communication of the absence of such a genotype. However, studies were predominantly at high or unclear risk of bias, and evidence was typically of low quality.Conclusions Expectations that communicating DNA based risk estimates changes behaviour is not supported by existing evidence.
AU  - Hollands,GJ
AU  - French,DP
AU  - Griffin,SJ
AU  - Prevost,AT
AU  - Sutton,S
AU  - King,S
AU  - Marteau,TM
DO  - 10.1136/bmj.i1102
PY  - 2016///
SN  - 1756-1833
TI  - The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis
T2  - BMJ
UR  - http://dx.doi.org/10.1136/bmj.i1102
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000372584400002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/43905
VL  - 352
ER  -
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