Imperial College London
Alternate

Professor Toby Prevost

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
//

Contact

 

a.prevost

 
 
//

Location

 

57Stadium HouseWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Sivaprasad:2017:10.1016/S0140-6736(17)31193-5,
author = {Sivaprasad, S and Prevost, AT and Vasconcelos, JC and Riddell, A and Murphy, C and Kelly, J and Bainbridge, J and Tudor-Edwards, R and Hopkins, D and Hykin, P},
doi = {10.1016/S0140-6736(17)31193-5},
journal = {Lancet},
pages = {2193--2203},
title = {Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial},
url = {http://dx.doi.org/10.1016/S0140-6736(17)31193-5},
volume = {389},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Proliferative diabetic retinopathy is the most common cause of severe sight impairment in people with diabetes. Proliferative diabetic retinopathy has been managed by panretinal laser photocoagulation (PRP) for the past 40 years. We report the 1 year safety and efficacy of intravitreal aflibercept.Methods:In this phase 2b, single-blind, non-inferiority trial (CLARITY), adults (aged ≥18 years) with type 1 or 2 diabetes and previously untreated or post-laser treated active proliferative diabetic retinopathy were recruited from 22 UK ophthalmic centres. Patients were randomly assigned (1:1) to repeated intravitreal aflibercept (2 mg/0·05 mL at baseline, 4 weeks, and 8 weeks, and from week 12 patients were reviewed every 4 weeks and aflibercept injections were given as needed) or PRP standard care (single spot or mutlispot laser at baseline, fractionated fortnightly thereafter, and from week 12 patients were assessed every 8 weeks and treated with PRP as needed) for 52 weeks. Randomisation was by minimisation with a web-based computer generated system. Primary outcome assessors were masked optometrists. The treating ophthalmologists and participants were not masked. The primary outcome was defined as a change in best-corrected visual acuity at 52 weeks with a linear mixed-effect model that estimated adjusted treatment effects at both 12 weeks and 52 weeks, having excluded fluctuations in best corrected visual acuity owing to vitreous haemorrhage. This modified intention-to-treat analysis was reapplied to the per protocol participants. The non-inferiority margin was prespecified as −5 Early Treatment Diabetic Retinopathy Study letters. Safety was assessed in all participants. This trial is registered with ISRCTN registry, number 32207582.Findings:We recruited 232 participants (116 per group) between Aug 22, 2014 and Nov 30, 2015. 221 participants (112 in aflibercept group, 109 in PRP group) contributed to the modified intention-to-treat model
AU  - Sivaprasad,S
AU  - Prevost,AT
AU  - Vasconcelos,JC
AU  - Riddell,A
AU  - Murphy,C
AU  - Kelly,J
AU  - Bainbridge,J
AU  - Tudor-Edwards,R
AU  - Hopkins,D
AU  - Hykin,P
DO  - 10.1016/S0140-6736(17)31193-5
EP  - 2203
PY  - 2017///
SN  - 0140-6736
SP  - 2193
TI  - Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial
T2  - Lancet
UR  - http://dx.doi.org/10.1016/S0140-6736(17)31193-5
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000402540800027&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/57307
VL  - 389
ER  -
Download