Imperial College London
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ProfessorAnnaRandi

Faculty of Medicine, National Heart & Lung Institute

Head of Section for Vascular Science
 
 
 
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Contact

 

a.randi Website

 
 
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Location

 

L-block, room 533Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kharwadkar:2023:10.4049/jimmunol.2200113,
author = {Kharwadkar, R and Ulrich, BJ and Chu, M and Koh, B and Hufford, MM and Fu, Y and Birdsey, GM and Porse, BT and Randi, AM and Kaplan, MH},
doi = {10.4049/jimmunol.2200113},
journal = {Journal of Immunology},
title = {ERG functionally overlaps with other Ets proteins in promoting TH9 cell expression of Il9 during allergic lung inflammation.},
url = {http://dx.doi.org/10.4049/jimmunol.2200113},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - CD4+ TH cells develop into subsets that are specialized in the secretion of particular cytokines to mediate restricted types of inflammation and immune responses. Among the subsets that promote development of allergic inflammatory responses, IL-9-producing TH9 cells are regulated by a number of transcription factors. We have previously shown that the E26 transformation-specific (Ets) family members PU.1 and Ets translocation variant 5 (ETV5) function in parallel to regulate IL-9. In this study we identified a third member of the Ets family of transcription factors, Ets-related gene (ERG), that mediates IL-9 production in TH9 cells in the absence of PU.1 and ETV5. Chromatin immunoprecipitation assays revealed that ERG interaction at the Il9 promoter region is restricted to the TH9 lineage and is sustained during murine TH9 polarization. Knockdown or knockout of ERG during murine or human TH9 polarization in vitro led to a decrease in IL-9 production in TH9 cells. Deletion of ERG in vivo had modest effects on IL-9 production in vitro or in vivo. However, in the absence of PU.1 and ETV5, ERG was required for residual IL-9 production in vitro and for IL-9 production by lung-derived CD4 T cells in a mouse model of chronic allergic airway disease. Thus, ERG contributes to IL-9 regulation in TH9 cells.
AU  - Kharwadkar,R
AU  - Ulrich,BJ
AU  - Chu,M
AU  - Koh,B
AU  - Hufford,MM
AU  - Fu,Y
AU  - Birdsey,GM
AU  - Porse,BT
AU  - Randi,AM
AU  - Kaplan,MH
DO  - 10.4049/jimmunol.2200113
PY  - 2023///
SN  - 0022-1767
TI  - ERG functionally overlaps with other Ets proteins in promoting TH9 cell expression of Il9 during allergic lung inflammation.
T2  - Journal of Immunology
UR  - http://dx.doi.org/10.4049/jimmunol.2200113
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36637217
UR  - https://journals.aai.org/jimmunol/article/doi/10.4049/jimmunol.2200113/237654/ERG-Functionally-Overlaps-with-Other-Ets-Proteins
ER  -
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