Imperial College London
Portrait Picture

Professor Alina Rodriguez, CPsychol

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0941a.rodriguez

 
 
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Location

 

168Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rodriguez:2019:10.1371/journal.pmed.1002746,
author = {Rodriguez, A and Wang, Y and Khan, AA and Cartwright, R and Gissler, M and Jarvelin, M-R},
doi = {10.1371/journal.pmed.1002746},
journal = {PLoS Medicine},
title = {Antenatal corticosteroid therapy (ACT) and size at birth: A population-based analysis using the Finnish Medical Birth Register},
url = {http://dx.doi.org/10.1371/journal.pmed.1002746},
volume = {16},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundAntenatal corticosteroid therapy (ACT) is used clinically to prepare the fetal lung for impending preterm birth, but animal and human studies link corticosteroids to smaller birth size. Whether ACT is associated with birth size is debated; therefore, we assessed differences in birth size in treated versus untreated pregnancies.Methods and findingsThis observational register-based study used data from the Finnish Medical Birth Register (FMBR) covering all births in Finland (January 1, 2006–December 31, 2010). We used unadjusted and adjusted regression analyses as well as propensity score matching (PSM) to analyze whether birth size differed by ACT exposure. PSM provides a stringent comparison, as subsamples were created matched on baseline and medical characteristics between treated and untreated women. All analyses were stratified by timing of birth. The primary study outcome was birth size: birth weight (BWT), birth length (BL), ponderal index (PI), and head circumference (HC) measured immediately after birth and recorded in the FMBR. Additional analyses explored indicators of neonatal health in relation to ACT exposure and birth size. A total of 278,508 live-born singleton births with ≥24 gestational completed weeks were registered in the FMBR during the 5-year study period. Over 4% of infants were born preterm, and 4,887 women were treated with ACT (1.75%). More than 44% of the exposed infants (n = 2,173) were born at term. First, results of unadjusted regression analyses using the entire sample showed the greatest reductions in BWT as compared to the other analytic methods: very preterm −61.26 g (±SE 24.12, P < 0.01), preterm −232.90 g (±SE 17.24, P < .001), near term −171.50 g (±SE 17.52, P < .001), and at term −101.95 g (±SE 10.89, P < .001). Second, using the entire sample, regression analyses adjusted for baseline and medical conditions showed significant differences in BWT be
AU  - Rodriguez,A
AU  - Wang,Y
AU  - Khan,AA
AU  - Cartwright,R
AU  - Gissler,M
AU  - Jarvelin,M-R
DO  - 10.1371/journal.pmed.1002746
PY  - 2019///
SN  - 1549-1277
TI  - Antenatal corticosteroid therapy (ACT) and size at birth: A population-based analysis using the Finnish Medical Birth Register
T2  - PLoS Medicine
UR  - http://dx.doi.org/10.1371/journal.pmed.1002746
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000460128900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/68156
VL  - 16
ER  -
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