Imperial College London
Portrait Picture

Professor Alina Rodriguez, CPsychol

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 0941a.rodriguez

 
 
//

Location

 

168Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Wiklund:2019:10.1186/s13148-019-0683-4,
author = {Wiklund, P and Karhunen, V and Richmond, RC and Parmar, P and Rodriguez, A and De, Silva M and Wielscher, M and Rezwan, F and Richardson, TG and Veijola, J and Herzig, K-H and Holloway, JW and Relton, CL and Sebert, S and Jarvelin, M-R},
doi = {10.1186/s13148-019-0683-4},
journal = {Clinical Epigenetics},
pages = {1--16},
title = {DNA methylation links prenatal smoking exposure to later life health outcomes in offspring},
url = {http://dx.doi.org/10.1186/s13148-019-0683-4},
volume = {11},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundMaternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship.MethodsWe examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring.ResultsWe identify 69 differentially methylated CpGs in 36 genomic regions (P value < 1 × 10−7) associated with exposure to maternal smoking in adolescents and adults. Mendelian randomization analyses provided evidence for a causal role of four maternal smoking-related CpG sites on an increased risk of inflammatory bowel disease or schizophrenia. Further mediation analyses showed some evidence of cg25189904 in GNG12 gene mediating the effect of exposure to maternal smoking on schizophrenia-related outcomes.ConclusionsDNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.
AU  - Wiklund,P
AU  - Karhunen,V
AU  - Richmond,RC
AU  - Parmar,P
AU  - Rodriguez,A
AU  - De,Silva M
AU  - Wielscher,M
AU  - Rezwan,F
AU  - Richardson,TG
AU  - Veijola,J
AU  - Herzig,K-H
AU  - Holloway,JW
AU  - Relton,CL
AU  - Sebert,S
AU  - Jarvelin,M-R
DO  - 10.1186/s13148-019-0683-4
EP  - 16
PY  - 2019///
SN  - 1868-7083
SP  - 1
TI  - DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
T2  - Clinical Epigenetics
UR  - http://dx.doi.org/10.1186/s13148-019-0683-4
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000474396300002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-019-0683-4
UR  - http://hdl.handle.net/10044/1/76326
VL  - 11
ER  -
Download