Imperial College London
Portrait Picture

Professor Alina Rodriguez, CPsychol

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0941a.rodriguez

 
 
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Location

 

168Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rodriguez:2021:10.1038/s41398-021-01584-4,
author = {Rodriguez, A},
doi = {10.1038/s41398-021-01584-4},
journal = {Translational Psychiatry},
pages = {1--8},
title = {The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations},
url = {http://dx.doi.org/10.1038/s41398-021-01584-4},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-directional MR on ADHD liability and six obesity-related traits using summary statistics from the largest available meta-analyses of genome-wide association studies. We also examined the shared genetic aetiology between ADHD symptoms (inattention and hyperactivity) and body mass index (BMI) by PRS association analysis using longitudinal data from Northern Finland Birth Cohort 1986 (NFBC1986, n = 2984). Lastly, we examined the impact of prenatal environment by association analysis of maternal pre-pregnancy BMI and offspring ADHD symptoms, adjusted for PRS of both traits, in NFBC1986 dataset. Through MR analyses, we found evidence for bidirectional causality between ADHD liability and obesity-related traits.  PRS association analyses showed evidence for genetic overlap between ADHD symptoms and BMI. We found no evidence for a difference between inattention and hyperactivity symptoms, suggesting that neither symptom subtype is driving the association. We found evidence for association between maternal pre-pregnancy BMI and offspring ADHD symptoms after adjusting for both BMI and ADHD PRS (association p-value = 0.027 for inattention, p = 0.008 for hyperactivity). These results are consistent with the hypothesis that the co-occurrence between ADHD and obesity has both genetic and prenatal environmental origins.
AU  - Rodriguez,A
DO  - 10.1038/s41398-021-01584-4
EP  - 8
PY  - 2021///
SN  - 2158-3188
SP  - 1
TI  - The link between Attention Deficit Hyperactivity Disorder (ADHD) symptoms and obesity-related traits: Genetic and prenatal explanations
T2  - Translational Psychiatry
UR  - http://dx.doi.org/10.1038/s41398-021-01584-4
UR  - https://www.nature.com/articles/s41398-021-01584-4
UR  - http://hdl.handle.net/10044/1/91255
VL  - 11
ER  -
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