Alex is a Research Associate whose work focuses on the detection of enteroviruses from stool and environmental samples. He works within the Vaccine Epidemiology Research Group (VERG) in the Department of Infectious Disease Epidemiology. The primary goal of his work is the detection and typing of poliovirus through next generation sequencing, with the aim of providing rapid and accurate information that could be used by the Global Poliovirus Eradication Initiative in the formation of response strategies.
His previous work has focused on the microbiota of infants, studying the correlation between the development of the gut microbiota and cases of necrotising enterocolitis and late-onset sepsis. This work was conducted as part of the Neonatal Microbiota study (NeoM), an ecological study of the microbiota of premature infants, which was supported by the Winnicott Foundation and Meningitis UK.
Alex completed his PhD at the University of Manchester where he applied Systems Biology approaches to the study of DNA replication in human cell lines. He also obtained a BSc in Biological Sciences and an MSc in Bioinformatics from Imperial College.
et al., 2021, Time taken to detect and respond to polio outbreaks in Africa and the potential impact of direct molecular detection and nanopore sequencing, Journal of Infectious Diseases, ISSN:0022-1899
et al., 2021, Premature neonatal gut microbial community patterns supporting an epithelial TLR-mediated pathway for necrotizing enterocolitis, Bmc Microbiology, Vol:21, ISSN:1471-2180, Pages:1-11
Shaw AG, Troman C, Grassly N, 2020, Rapid and sensitive direct detection and identification of poliovirus from stool and environmental surveillance samples using nanopore sequencing, Journal of Clinical Microbiology, Vol:58, ISSN:0095-1137, Pages:1-13
et al., 2020, Microbiota supplementation with Bifidobacterium and Lactobacillus modifies the preterm infant gut microbiota and metabolome: an observational study, Cell Reports Medicine, Vol:1, ISSN:2666-3791
et al., 2020, The role of genetic sequencing and analysis in the polio eradication program, Virus Evolution, Vol:6, ISSN:2057-1577