My laboratory is based at the MRC Centre for Molecular Bacteriology & Infection (CMBI) at the South Kensington campus. We study the role of inflammasome signalling networks in host immunity and inflammation. I also have a Satellite Group at the Francis Crick Institute, London.
Inflammasomes are large multimeric signalling scaffolds that activate caspase-1. Inflammasome activation can also require assistance from caspase-4 (also called caspase-11 in the mouse), and caspase-8. Together, these inflammatory caspases launch a robust host defence programme by acting on their targets. My laboratory studies inflammasomes in the context of infection by enteric bacterial pathogens e.g. Salmonella and pathogenic E. coli. We also collaborate with groups within the CMBI to study infections by pathogens such as Mycobacterium and Shigella, and outside Imperial on pathogens such as Toxoplasma gondii.
In addition, inflammasomes can also instigate autoinflammation associated with various non-communicable diseases, including the metabolic syndrome, diabetes and cancer. We are also interested in investigating how natural genetic mutations can predispose individuals to inflammation.
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I am the Stream Lead for the Bacterial Pathogenesis & Infection stream within the MRes in Biomedical Research programme. If you are interested in a rotation project in my group, please email me and I'll be happy to chat to you. I also conduct Workshops for MRes/PhD students.
1. MRes in MRes Biomedical Research - Bacterial Pathogenesis and Infection
2. MSc in Immunology
3. BSc in Medical Sciences with Immunity and Infection
4. Biomedical Science degrees course on Molecular Basis of Bacterial Infection
5. Workshop on Biological Statistics
6. Workshop on Scientific Writing
If you are interested in our work, rotation projects are available! Please get in touch via email and come and meet me at the Flowers Bldg, South Kensington Campus.
Education and employment history:
At Imperial since 2013
Postdoc: Yale University (New Haven, USA)
Integrated MS-PhD: Indian Institute of Science (Bengaluru, India)
BSc (Microbiology, Biotechnology, Chemistry): Ramnarain Ruia College (University of Mumbai, India).
et al., 2020, Human GBP1 differentially targets salmonella and toxoplasma to license recognition of microbial ligands and caspase-mediated death, Cell Reports, Vol:32, ISSN:2211-1247, Pages:1-22
Sanchez-Garrido J, Shenoy A, 2020, Regulation and repurposing of nutrient sensing and autophagy in innate immunity, Autophagy, ISSN:1554-8627
et al., 2020, Vying for the control of inflammasomes: the cytosolic frontier of enteric bacterial pathogen - host interactions, Cellular Microbiology, Vol:22, ISSN:1462-5814, Pages:1-19
et al., 2019, Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis, EMBO Journal, Vol:38, ISSN:0261-4189
et al., 2019, Enteropathogenic E. coli stimulates effector-driven rapid caspase-4 activation in human macrophages, Cell Reports, Vol:27, ISSN:2211-1247, Pages:1008-1017.e6
Sanchez-Garrdio J, Sancho-Shimizu V, Shenoy A, 2018, Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing, Science Signaling, Vol:11, ISSN:1937-9145
et al., 2017, The atypical ubiquitin E2 conjugase UBE2L3 is an indirect caspase-1 target and controls IL-1beta secretion by inflammasomes, Cell Reports, Vol:18, ISSN:2211-1247, Pages:1285-1297
et al., 2016, Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death, Nature Communications, Vol:7, ISSN:2041-1723
Surana S, Shenoy AR, Krishnan Y, 2015, Designing DNA nanodevices for compatibility with the immune system of higher organisms, Nature Nanotechnology, Vol:10, ISSN:1748-3395, Pages:741-747
Mostowy S, Shenoy AR, 2015, The cytoskeleton in cell-autonomous immunity: structural determinants of host defence, Nature Reviews Immunology, Vol:15, ISSN:1474-1741, Pages:559-573
et al., 2012, GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals, Science, Vol:336, ISSN:0036-8075, Pages:481-485
et al., 2011, A Family of IFN-gamma-Inducible 65-kD GTPases Protects Against Bacterial Infection, Science, Vol:332, ISSN:0036-8075, Pages:717-721
Shenoy AR, Visweswariah SS, 2006, New messages from old messengers: cAMP and mycobacteria, Trends in Microbiology, Vol:14, ISSN:0966-842X, Pages:543-550
Shenoy AR, Visweswariah SS, 2004, Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases, FEBS Letters, Vol:561, ISSN:0014-5793, Pages:11-21
Shenoy AR, Visweswariah SS, 2003, Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA, Analytical Biochemistry, Vol:319, ISSN:0003-2697, Pages:335-336