My laboratory is housed at the MRC CMBI at the South Kensington campus, and studies the role of inflammasome signalling networks in host immunity and inflammation.
Inflammasomes are large multimeric signalling scaffolds that activate caspase-1. Inflammasome activation can also require assistance from caspase-4 (also called caspase-11 in the mouse), and caspase-8. Together, these inflammatory caspases launch a robust host defence programme by acting on their targets. My laboratory studies inflammasomes in the context of infection by enteric bacterial pathogens such as Salmonella, Listeria and pathogenic E. coli.
In addition, the same pathways can also instigate autoinflammation associated with various modern-day diseases, including the metabolic syndrome, diabetes and cancer.
Therefore studying them is important not only for obtaining a better understanding of the fundamental principles of the host response, but also for designing better therapeutics in the future.
New advert for postdoctoral position in my group - now online
I am involved in teaching in the following courses
1. MRes in MRes Biomedical Research - Bacterial Pathogenesis and Infection
2. MSc in Immunology
3. BSc in Medical Sciences with Immunity and Infection
4. Biomedical Science degrees course on Molecular Basis of Bacterial Infection
If you are interested in our work, rotation projects are available! Please get in touch via email and come and meet me at the Flowers Bldg, South Kensington Campus.
Education and employment history:
2013 - present Non-clinical Lecturer in Molecular Microbiology, Imperial College London
2006-2013 - Post doctoral researcher, Dept of Microbial Pathogenesis, Yale University School of Medicine
2005-2006 - Research Associate, Indian Institute of Science, Bengaluru, India.
2000-2005 - Integrated MS/PhD student, Indian Institute of Science, Bengaluru, India.
1999-2000 - BSc in Microbiology and Biotechnology, Ramnarain Ruia College, University of Mumbai, India.
et al., 2017, The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1 beta Secretion by Inflammasomes, Cell Reports, Vol:18, ISSN:2211-1247, Pages:1285-1297
Surana S, Shenoy AR, Krishnan Y, 2015, Designing DNA nanodevices for compatibility with the immune system of higher organisms, Nature Nanotechnology, Vol:10, ISSN:1748-3387, Pages:741-747
Mostowy S, Shenoy AR, 2015, The cytoskeleton in cell-autonomous immunity: structural determinants of host defence, Nature Reviews Immunology, Vol:15, ISSN:1474-1733, Pages:559-573
Eldridge MJG, Shenoy AR, 2015, Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens, Current Opinion in Microbiology, Vol:23, ISSN:1369-5274, Pages:32-41
Shenoy AR, Visweswariah SS, 2004, Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases, FEBS Letters, Vol:561, ISSN:0014-5793, Pages:11-21
Shenoy AR, Visweswariah SS, 2003, Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA, Analytical Biochemistry, Vol:319, ISSN:0003-2697, Pages:335-336
Shenoy AR, Visweswariah SS, 2006, New messages from old messengers: cAMP and mycobacteria, Trends in Microbiology, Vol:14, ISSN:0966-842X, Pages:543-550
et al., 2007, Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families, Immunobiology, Vol:212, ISSN:0171-2985, Pages:771-784
et al., 2012, GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals, Science, Vol:336, ISSN:0036-8075, Pages:481-485
et al., 2011, A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection., Science, Vol:332, Pages:717-721