My laboratory is housed at the MRC Centre for Molecular Bacteriology & Infection (CMBI) at the South Kensington campus. We study the role of inflammasome signalling networks in host immunity and inflammation. I also have a Satellite Group at the Francis Crick Institute, London.
Inflammasomes are large multimeric signalling scaffolds that activate caspase-1. Inflammasome activation can also require assistance from caspase-4 (also called caspase-11 in the mouse), and caspase-8. Together, these inflammatory caspases launch a robust host defence programme by acting on their targets. My laboratory studies inflammasomes in the context of infection by enteric bacterial pathogens e.g. Salmonella and pathogenic E. coli. We also collaborate with groups within the CMBI to study infections by pathogens such as Mycobacterium and Shigella.
In addition, inflammasomes can also instigate autoinflammation associated with various modern-day diseases, including the metabolic syndrome, diabetes and cancer. We are also interested in investigating how natural genetic mutations can predispose individuals to inflammation.
Therefore studying them is important not only for obtaining a better understanding of the fundamental principles of the host response, but also for designing better therapeutics in the future.
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I am involved in lecture-based teaching and mentoring rotation projects in following courses. If you are interested in a rotation project in my group, please email me and I'll be happy to chat to you.
1. MRes in MRes Biomedical Research - Bacterial Pathogenesis and Infection
2. MSc in Immunology
3. BSc in Medical Sciences with Immunity and Infection
4. Biomedical Science degrees course on Molecular Basis of Bacterial Infection
If you are interested in our work, rotation projects are available! Please get in touch via email and come and meet me at the Flowers Bldg, South Kensington Campus.
Education and employment history:
I started at Imperial in 2013, before which I was a postdoc at Yale University (New Haven, USA), and integrated MS-PhD scholar at the Indian Institute of Science (Bengaluru, India), and a BSc Microbiology-Biotechnology student at Ramnarain Ruia College, University of Mumbai (India).
Sanchez-Garrido J, Sancho-Shimizu V, Shenoy AR, 2018, Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing, Science Signaling, Vol:11, ISSN:1945-0877
et al., 2017, Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells, Mucosal Immunology, Vol:10, ISSN:1933-0219, Pages:602-612
et al., 2017, The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1 beta Secretion by Inflammasomes, Cell Reports, Vol:18, ISSN:2211-1247, Pages:1285-1297
et al., 2016, Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death, Nature Communications, Vol:7, ISSN:2041-1723
Surana S, Shenoy AR, Krishnan Y, 2015, Designing DNA nanodevices for compatibility with the immune system of higher organisms, Nature Nanotechnology, Vol:10, ISSN:1748-3387, Pages:741-747
Mostowy S, Shenoy AR, 2015, The cytoskeleton in cell-autonomous immunity: structural determinants of host defence, Nature Reviews Immunology, Vol:15, ISSN:1474-1733, Pages:559-573
Eldridge MJG, Shenoy AR, 2015, Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens, Current Opinion in Microbiology, Vol:23, ISSN:1369-5274, Pages:32-41
et al., 2012, GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals, Science, Vol:336, ISSN:0036-8075, Pages:481-485
et al., 2011, A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection., Science, Vol:332, Pages:717-721
Shenoy AR, Visweswariah SS, 2006, New messages from old messengers: cAMP and mycobacteria, Trends in Microbiology, Vol:14, ISSN:0966-842X, Pages:543-550
Shenoy AR, Visweswariah SS, 2004, Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases, Febs Letters, Vol:561, ISSN:1873-3468, Pages:11-21
Shenoy AR, Visweswariah SS, 2003, Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA, Analytical Biochemistry, Vol:319, ISSN:0003-2697, Pages:335-336