Imperial College London

Avinash R. Shenoy

Faculty of MedicineDepartment of Medicine

Non-Clinical Lecturer in Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 3785a.shenoy Website

 
 
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Location

 

4.40AFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kim:2011:10.1126/science.1201711,
author = {Kim, B-H and Shenoy, AR and Kumar, P and Das, R and Tiwari, S and MacMicking, JD},
doi = {10.1126/science.1201711},
journal = {Science},
pages = {717--721},
title = {A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.},
url = {http://dx.doi.org/10.1126/science.1201711},
volume = {332},
year = {2011}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Immune interferon gamma (IFN-γ) is essential for mammalian host defense against intracellular pathogens. IFN-γ induces nearly 2000 host genes, yet few have any assigned function. Here, we examined a complete mouse 65-kilodalton (kD) guanylate-binding protein (Gbp) gene family as part of a 43-member IFN-γ-inducible guanosine triphosphatase (GTPase) superfamily in mouse and human genomes. Family-wide loss-of-function analysis found that at least four Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous immunity to listerial or mycobacterial infection within macrophages and gene-deficient animals. These Gbps solicited host defense proteins, including the phagocyte oxidase, antimicrobial peptides, and autophagy effectors, to kill intracellular bacteria. Thus, specific 65-kD Gbps coordinate a potent oxidative and vesicular trafficking program to protect the host from infection.
AU - Kim,B-H
AU - Shenoy,AR
AU - Kumar,P
AU - Das,R
AU - Tiwari,S
AU - MacMicking,JD
DO - 10.1126/science.1201711
EP - 721
PY - 2011///
SP - 717
TI - A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.
T2 - Science
UR - http://dx.doi.org/10.1126/science.1201711
UR - https://www.ncbi.nlm.nih.gov/pubmed/21551061
VL - 332
ER -