Summary
My laboratory is based at the MRC Centre for Molecular Bacteriology & Infection (CMBI) at the South Kensington campus. We study the role of inflammasome signalling networks in host immunity to infection. I also have a Satellite Group at the Francis Crick Institute, London.
Our interests include infection by bacteria such as Salmonella, enteropathogenic E. coli, Mycobacterium, and others. We address questions such as, how do inflammasomes help in defence against these pathogens? How do inflammasomes cause damage when they become overactive or deregulated?
We also work on mechanisms and consequences of antibiotic resistance in Enterobacter cloacae, a major drug-resistant nosocomial pathogen.
Follow our group on Twitter.
Teaching:
I am the Stream Lead for the Bacterial Pathogenesis & Infection stream within the MRes in Biomedical Research programme. If you are interested in a rotation project in my group, please email me and I'll be happy to chat to you. I also conduct Workshops for MRes/PhD students.
1. MRes in MRes Biomedical Research - Bacterial Pathogenesis and Infection
2. MSc in Immunology
3. BSc in Medical Sciences with Immunity and Infection
4. Biomedical Science degrees course on Molecular Basis of Bacterial Infection
5. Workshop on Biological Statistics
6. Workshop on Scientific Writing
If you are interested in our work, rotation projects are available! Please get in touch via email and come and meet me at the Flowers Bldg, South Kensington Campus.
Education and employment history:
At Imperial since 2013
Postdoc: Yale University (New Haven, USA)
Integrated MS-PhD: Indian Institute of Science (Bengaluru, India)
BSc (Microbiology, Biotechnology, Chemistry): Ramnarain Ruia College (University of Mumbai, India).
Selected Publications
Journal Articles
Fisch D, Clough B, Domart M-C, et al., 2020, Human GBP1 differentially targets salmonella and toxoplasma to license recognition of microbial ligands and caspase-mediated death, Cell Reports, Vol:32, ISSN:2211-1247, Pages:1-22
Sanchez-Garrido J, Shenoy A, 2020, Regulation and repurposing of nutrient sensing and autophagy in innate immunity, Autophagy, Vol:17, ISSN:1554-8627, Pages:1571-1591
Sanchez Garrido J, Slater SL, Clements A, et al., 2020, Vying for the control of inflammasomes: the cytosolic frontier of enteric bacterial pathogen - host interactions, Cellular Microbiology, Vol:22, ISSN:1462-5814, Pages:1-19
Fisch D, Bando H, Clough B, et al., 2019, Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis, EMBO Journal, Vol:38, ISSN:0261-4189
Goddard P, Sanchez Garrido J, Slater S, et al., 2019, Enteropathogenic E. coli stimulates effector-driven rapid caspase-4 activation in human macrophages, Cell Reports, Vol:27, ISSN:2211-1247, Pages:1008-1017.e6
Sanchez-Garrdio J, Sancho-Shimizu V, Shenoy A, 2018, Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing, Science Signaling, Vol:11, ISSN:1937-9145
Eldridge MJG, Sanchez Garrido J, Hoben GF, et al., 2017, The atypical ubiquitin E2 conjugase UBE2L3 is an indirect caspase-1 target and controls IL-1beta secretion by inflammasomes, Cell Reports, Vol:18, ISSN:2211-1247, Pages:1285-1297
Thurston T, Matthews S, Jennings E, et al., 2016, Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death, Nature Communications, Vol:7, ISSN:2041-1723
Surana S, Shenoy AR, Krishnan Y, 2015, Designing DNA nanodevices for compatibility with the immune system of higher organisms, Nature Nanotechnology, Vol:10, ISSN:1748-3395, Pages:741-747
Mostowy S, Shenoy AR, 2015, The cytoskeleton in cell-autonomous immunity: structural determinants of host defence, Nature Reviews Immunology, Vol:15, ISSN:1474-1741, Pages:559-573
Shenoy AR, Wellington DA, Kumar P, et al., 2012, GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals, Science, Vol:336, ISSN:0036-8075, Pages:481-485
Kim B-H, Shenoy AR, Kumar P, et al., 2011, A Family of IFN-γ-Inducible 65-kD GTPases Protects Against Bacterial Infection, Science, Vol:332, ISSN:0036-8075, Pages:717-721
Shenoy AR, Visweswariah SS, 2006, New messages from old messengers: cAMP and mycobacteria, Trends in Microbiology, Vol:14, ISSN:0966-842X, Pages:543-550
Shenoy AR, Visweswariah SS, 2004, Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases, FEBS Letters, Vol:561, ISSN:0014-5793, Pages:11-21
Shenoy AR, Visweswariah SS, 2003, Site-directed mutagenesis using a single mutagenic oligonucleotide and <i>Dpn</i>I digestion of template DNA, Analytical Biochemistry, Vol:319, ISSN:0003-2697, Pages:335-336