Imperial College London
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Avinash R. Shenoy

Faculty of Medicine, Department of Infectious Disease

Reader in Innate Immunity and Infection
 
 
 
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Contact

 

+44 (0)20 7594 3785a.shenoy Website

 
 
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Location

 

4.40AFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mostowy:2015:10.1038/nri3877,
author = {Mostowy, S and Shenoy, AR},
doi = {10.1038/nri3877},
journal = {Nature Reviews Immunology},
pages = {559--573},
title = {The cytoskeleton in cell-autonomous immunity: structural determinants of host defence},
url = {http://dx.doi.org/10.1038/nri3877},
volume = {15},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton — actin, microtubules, intermediate filaments and septins, which are well known for their roles in cell division, shape and movement — have important functions in innate immunity and cellular self-defence. Investigations using cellular and animal models have shown that these cytoskeletal proteins are crucial for sensing bacteria and for mobilizing effector mechanisms to eliminate them. In this Review, we highlight the emerging roles of the cytoskeleton as a structural determinant of cell-autonomous host defence.
AU  - Mostowy,S
AU  - Shenoy,AR
DO  - 10.1038/nri3877
EP  - 573
PY  - 2015///
SN  - 1474-1741
SP  - 559
TI  - The cytoskeleton in cell-autonomous immunity: structural determinants of host defence
T2  - Nature Reviews Immunology
UR  - http://dx.doi.org/10.1038/nri3877
UR  - http://hdl.handle.net/10044/1/31214
VL  - 15
ER  -
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