Imperial College London
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Avinash R. Shenoy

Faculty of Medicine, Department of Infectious Disease

Reader in Innate Immunity and Infection
 
 
 
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Contact

 

+44 (0)20 7594 3785a.shenoy Website

 
 
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Location

 

4.40AFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Surana:2015:10.1038/NNANO.2015.180,
author = {Surana, S and Shenoy, AR and Krishnan, Y},
doi = {10.1038/NNANO.2015.180},
journal = {Nature Nanotechnology},
pages = {741--747},
title = {Designing DNA nanodevices for compatibility with the immune system of higher organisms},
url = {http://dx.doi.org/10.1038/NNANO.2015.180},
volume = {10},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - DNA is proving to be a powerful scaffold to construct molecularly precise designer DNA devices. Recent trends reveal their ever-increasing deployment within living systems as delivery devices that not only probe but also program and re-program a cell, or even whole organisms. Given that DNA is highly immunogenic, we outline the molecular, cellular and organismal response pathways that designer nucleic acid nanodevices are likely to elicit in living systems. We address safety issues applicable when such designer DNA nanodevices interact with the immune system. In light of this, we discuss possible molecular programming strategies that could be integrated with such designer nucleic acid scaffolds to either evade or stimulate the host response with a view to optimizing and widening their applications in higher organisms.
AU  - Surana,S
AU  - Shenoy,AR
AU  - Krishnan,Y
DO  - 10.1038/NNANO.2015.180
EP  - 747
PY  - 2015///
SN  - 1748-3395
SP  - 741
TI  - Designing DNA nanodevices for compatibility with the immune system of higher organisms
T2  - Nature Nanotechnology
UR  - http://dx.doi.org/10.1038/NNANO.2015.180
UR  - http://hdl.handle.net/10044/1/31298
VL  - 10
ER  -
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