Imperial College London

Avinash R. Shenoy

Faculty of MedicineDepartment of Medicine

Non-Clinical Lecturer in Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 3785a.shenoy Website

 
 
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Location

 

4.40AFlowers buildingSouth Kensington Campus

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Summary

 

Caspases in immunity & inflammation

My laboratory is broadly interested in understanding the mechanisms of inflammasome signalling. Inflammasomes are molecular complexes that assemble in response to microbe- or danger-signal and activate caspase-1. Other inflammatory caspases, such as caspase-4, -5 (both together represented by a single caspase-11 in the mouse) and caspase-8, also regulate these pathways. My group is interested in these caspases and their contribution to health and disease.  

We are studying new cell-intrinsic roles of caspases in inflammation and immunity. See Research Highlights to see our recent work, which was on the cover of Science Signaling.

 

Laboratory Members

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Lab 2018Tereza Masonou, Avinash Shenoy, Anna Crespo and Marc Stringer (2018).
Matthew Eldridge, Avinash, Julia Sanchez, Philippa Goddard (Left to Right)

Matthew Eldridge, Avinash Shenoy, Julia Sanchez and Philippa Goddard (2016).

Research highlights

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Science Signaling
Free full-text access to our paper "Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing" is available here: Summary, Abstract, Full text, Reprint

Innate immunity and the cytoskeleton

Role of cytoskeleton proteins and innate immunity against bacterial pathogens.

 

DNA nanodevices the host response 

DNA nanodevices and the host response.

 

Simplified view of inflammasome signalling

Inflammasome signalling pathways in antibacterial host defence.

Collaborators

Abigal Clements, Imperial College London, Inflammasome responses to Shigella infection

Andrew Edwards, Imperial College London, Boosting innate immune response to clear bacterial infections

Brian Robertson, Imperial College London, Mechanisms of differential inflammasome activation by clinical isolates of M. tuberculosis

Gad Frankel, Imperial College London, Host immunity to pathogenic E. coli

David Holden, Imperial College London, Salmonella Typhimurium, inflammasomes, antimicrobial responses,

Ed Tate, Imperial College London, Chemical biology, protein geranylylation, ubiquitylation

Vanessa Sancho-Shimizu, Imperial College London, TLR3 signalling, anti-viral immunity, autophagy

Sandhya S. Visweswariah, Indian Institute of Science, Second messenger signalling, gut physiology and inflammation

Eva Frickel, The Francis Crick Institute, Inflammasome signalling during Toxoplasma infection

Dr. Eva Frickel, The Francis Crick Institute, Mechanisms of detection and defence against Toxoplasma

Guest Lectures

New Molecular Rheostats in Inflammasome Signalling Pathways, University of Aberdeen, Aberdeen, 2016

Antibacterial Host Defence via the Inflammasomes, University of Melbourne, Melbourne, Australia

Inflammasome Effectors of Host Defence against Bacterial Infection, University of Plymouth, Plymouth, 2015

Immunity ‘On Demand’: Inducible GTPases, Inflammasomes and Beyond, University College London, London, 2014

GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals., Salk/Nature/Ipsen Symposium on Biological Complexity: Immunity and Inflammation., Salk Institute for Biological Studies, San Diego, USA., 2012

Research Staff

Kalyan,M

Research Student Supervision

Eldridge,MJE, Inflammasome effector mechanisms in antimicrobial immunity: Novel caspase-1 targets and their roles in host defence

Goddard,PJ, Manipulation of macrophage programmed cell death pathways by Enteropathogenic Escherichia coli

Hamway,Y, Caspase substrates in host defence, and role of bacterial effectors in counteracting them

Sanchez-Garrido,J, Cell intrinsic actions of caspase-1 via its substrates and targets