Caspases in immunity & inflammation
My laboratory is broadly interested in understanding the mechanisms of inflammasome signalling. Inflammasomes are molecular complexes that assemble in response to microbe- or danger-signal and activate caspase-1. Other inflammatory caspases, such as caspase-4, -5 (both together represented by a single caspase-11 in the mouse) and caspase-8, also regulate these pathways. My group is interested in these caspases and their contribution to health and disease.
We are studying new cell-intrinsic roles of caspases in inflammation and immunity. See Research Highlights to see our recent work, which was on the cover of Science Signaling.
Tereza Masonou, Avinash Shenoy, Anna Crespo and Marc Stringer (2018).
Matthew Eldridge, Avinash Shenoy, Julia Sanchez and Philippa Goddard (2016).
Abigal Clements, Imperial College London, Inflammasome responses to Shigella infection
Andrew Edwards, Imperial College London, Boosting innate immune response to clear bacterial infections
Brian Robertson, Imperial College London, Mechanisms of differential inflammasome activation by clinical isolates of M. tuberculosis
Gad Frankel, Imperial College London, Host immunity to pathogenic E. coli
David Holden, Imperial College London, Salmonella Typhimurium, inflammasomes, antimicrobial responses,
Ed Tate, Imperial College London, Chemical biology, protein geranylylation, ubiquitylation
Vanessa Sancho-Shimizu, Imperial College London, TLR3 signalling, anti-viral immunity, autophagy
Sandhya S. Visweswariah, Indian Institute of Science, Second messenger signalling, gut physiology and inflammation
Eva Frickel, The Francis Crick Institute, Inflammasome signalling during Toxoplasma infection
Dr. Eva Frickel, The Francis Crick Institute, Mechanisms of detection and defence against Toxoplasma
New Molecular Rheostats in Inflammasome Signalling Pathways, University of Aberdeen, Aberdeen, 2016
Antibacterial Host Defence via the Inflammasomes, University of Melbourne, Melbourne, Australia
Inflammasome Effectors of Host Defence against Bacterial Infection, University of Plymouth, Plymouth, 2015
Immunity ‘On Demand’: Inducible GTPases, Inflammasomes and Beyond, University College London, London, 2014
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals., Salk/Nature/Ipsen Symposium on Biological Complexity: Immunity and Inflammation., Salk Institute for Biological Studies, San Diego, USA., 2012
Research Student Supervision
Eldridge,MJE, Inflammasome effector mechanisms in antimicrobial immunity: Novel caspase-1 targets and their roles in host defence
Goddard,PJ, Manipulation of macrophage programmed cell death pathways by Enteropathogenic Escherichia coli
Hamway,Y, Caspase substrates in host defence, and role of bacterial effectors in counteracting them
Sanchez-Garrido,J, Cell intrinsic actions of caspase-1 via its substrates and targets