Imperial College London

Professor A G M Barrett, FRS, FMedSci

Faculty of Natural SciencesDepartment of Chemistry

Head of Synthesis
 
 
 
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Contact

 

+44 (0)20 7594 5766agm.barrett

 
 
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Assistant

 

Ms Virginia Manch +44 (0)20 7594 5767

 
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Location

 

733ChemistrySouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

473 results found

Almond-Thynne J, White AJP, Polyzos A, Rzepa HS, Parsons PJ, Barrett AGMet al., 2017, Synthesis and Reactions of Benzannulated Spiroaminals: Tetrahydrospirobiquinolines, ACS OMEGA, Vol: 2, Pages: 3241-3249, ISSN: 2470-1343

JOURNAL ARTICLE

Hazel P, Kroll SHB, Bondke A, Barbazanges M, Patel H, Fuchter MJ, Coombes RC, Ali S, Barrett AGM, Freemont PSet al., 2017, Inhibitor Selectivity for Cyclin-Dependent Kinase7: AStructural, Thermodynamic, and Modelling Study, CHEMMEDCHEM, Vol: 12, Pages: 372-380, ISSN: 1860-7179

JOURNAL ARTICLE

Kandela IK, McAuliffe KJ, Cochran LE, Barrett AGM, Hoffman BM, Mazar AP, Trivedi ERet al., 2017, Discovery of the Antitumor Effects of a Porphyrazine Diol (Pz 285) in MDA-MB-231 Breast Tumor Xenograft Models in Mice., ACS Med Chem Lett, Vol: 8, Pages: 705-709, ISSN: 1948-5875

A series of porphyrazines (Pzs) with chiral bis-acetal moieties in the β-pyrrole positions ((2R,3R)-2,3-dimethyl-2,3-dimethoxy-1,4-diox-2-ene) have been synthesized and screened as antitumor agents in MDA-MB-231 breast tumor cells in vitro. The lead Pz 285 was further tested in a mouse tumor xenograft model with Td-tomato-luc2 fluorescent breast tumor cells (MDA-MB-231 LM24 Her2+) that are highly metastatic to the lungs. Pz 285 shows marked antitumor effects in vivo, with treated mice exhibiting longer median survival that we attribute to smaller primary tumor regrowth after resection and less occurrence of metastasis when compared to vehicle control groups. Pz 285 is further compared to the clinically approved chemotherapeutic doxorubicin (Dox). This report lays the groundwork for development of an understudied class of compounds for classical chemotherapy.

JOURNAL ARTICLE

Ali S, Patel H, Periyasamy M, Bondke A, Slafer BW, Ottaviani S, Harrod A, Buluwela L, Fuchter MJ, Barrett AGM, Coombes RCet al., 2016, ICEC0942, an orally bioavailable selective inhibitor of CDK7 for breast cancer, UK Breast Cancer Research Symposium, Publisher: SPRINGER, Pages: 195-195, ISSN: 0167-6806

CONFERENCE PAPER

Elliott DC, Ma T-K, Selmani A, Cookson R, Parsons PJ, Barrett AGMet al., 2016, Sequential Ketene Generation from Dioxane-4,6-dione-keto-dioxinones for the Synthesis of Terpenoid Resorcylates, ORGANIC LETTERS, Vol: 18, Pages: 1800-1803, ISSN: 1523-7060

JOURNAL ARTICLE

Cookson R, Barrett TN, Barrett AGM, 2015, beta-Keto-dioxinones and beta,delta-Diketo-dioxinones in Biomimetic Resorcylate Total Synthesis, ACCOUNTS OF CHEMICAL RESEARCH, Vol: 48, Pages: 628-642, ISSN: 0001-4842

JOURNAL ARTICLE

Doepner AM, Aboagye EO, Barrett AGM, 2015, 2 '-Deoxy-2 ',2 '-difluorothymidine analogues for radiolabeling with fluorine-18 and other biomedical applications, TETRAHEDRON LETTERS, Vol: 56, Pages: 3293-3297, ISSN: 0040-4039

JOURNAL ARTICLE

Palma A, Serginson JM, Barrett AGM, 2015, Synthesis of poly beta ketoesters via double acylketene trapping, TETRAHEDRON LETTERS, Vol: 56, Pages: 674-676, ISSN: 0040-4039

JOURNAL ARTICLE

Anderson K, Laclef S, Barrett AGM, 2014, Mechanistic studies of highly regioselective decarboxylative-prenyl migration reactions of prenyloxycarbonyl-diketo-dioxinones, TETRAHEDRON, Vol: 70, Pages: 5569-5579, ISSN: 0040-4020

JOURNAL ARTICLE

Barrett TN, Barrett AGM, 2014, Cascade Polyketide and Polyene Cyclizations: Biomimetic Total Synthesis of Hongoquercin B, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 136, Pages: 17013-17015, ISSN: 0002-7863

JOURNAL ARTICLE

Barrett TN, Patel BH, Barrett AGM, 2014, Synthesis of C-5-substituted resorcylates and resorcinamides via formylation-aromatization of functionalized keto-dioxinones, TETRAHEDRON, Vol: 70, Pages: 6894-6901, ISSN: 0040-4020

JOURNAL ARTICLE

Blencowe PS, Barrett AGM, 2014, Biomimetic Synthesis of Functionalized gamma-Resorcylates from Dioxinone Derivatives, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Pages: 4844-4853, ISSN: 1434-193X

JOURNAL ARTICLE

Brookes PA, Barrett AGM, 2014, Iodoaromatization Reactions of Enyne-Dioxinones: Syntheses of 4H-1,3-Benzodioxin-4-ones, Masked Pentasubstituted Arenes, JOURNAL OF ORGANIC CHEMISTRY, Vol: 79, Pages: 8706-8714, ISSN: 0022-3263

JOURNAL ARTICLE

Cookson R, Poeverlein C, Lachs J, Barrett AGMet al., 2014, Synthetic Studies towards Radicicol through Biomimetic Macrolactonization and Transannular Aromatization Reactions, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Pages: 4523-4535, ISSN: 1434-193X

JOURNAL ARTICLE

Kim M-S, Buisson LA, Heathcote DA, Hu H, Braddock DC, Barrett AGM, Ashton-Rickardt PG, Snyder JPet al., 2014, Approaches to design non-covalent inhibitors for human granzyme B (hGrB), ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 12, Pages: 8952-8965, ISSN: 1477-0520

JOURNAL ARTICLE

Loerbroks C, Boeker B, Cordes J, Barrett AGM, Thiel Wet al., 2014, Spiroaminals - Crystal Structure and Computational Investigation of Conformational Preferences and Tautomerization Reactions, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Pages: 5476-5486, ISSN: 1434-193X

JOURNAL ARTICLE

Reid S, Barrett AGM, Hill MS, Procopiou PAet al., 2014, Heavier Alkaline Earth Catalyzed Ene-yne Cyclizations: Atom-Efficient Access to Tetrahydroisoquinoline Frameworks, ORGANIC LETTERS, Vol: 16, Pages: 6016-6019, ISSN: 1523-7060

JOURNAL ARTICLE

Trivedi ER, Ma Z, Waters EA, Macrenaris KW, Subramanian R, Barrett AGM, Meade TJ, Hoffman BMet al., 2014, Synthesis and characterization of a porphyrazine-Gd(III) MRI contrast agent and in vivo imaging of a breast cancer xenograft model, CONTRAST MEDIA & MOLECULAR IMAGING, Vol: 9, Pages: 313-322, ISSN: 1555-4309

JOURNAL ARTICLE

Brookes PA, Cordes J, White AJP, Barrett AGMet al., 2013, Total Synthesis of Mycophenolic Acid by a Palladium-Catalyzed Decarboxylative Allylation and Biomimetic Aromatization Sequence, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol: 2013, Pages: 7313-7319, ISSN: 1434-193X

JOURNAL ARTICLE

Cordes J, Barrett AGM, 2013, Synthesis of Macrosporin and Related 9,10-Anthraquinones by Biomimetic Polyketide Aromatization and Cyclization of 6-Benzylresorcylates, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Pages: 1318-1326, ISSN: 1434-193X

JOURNAL ARTICLE

Cordes J, Murray PRD, White AJP, Barrett AGMet al., 2013, 1,7-Diazaspiro[5.5]undecane - A Neglected Heterocycle, ORGANIC LETTERS, Vol: 15, Pages: 4992-4995, ISSN: 1523-7060

JOURNAL ARTICLE

George NS, Anderson KE, Barrett AGM, 2013, Total Synthesis of Cristatic Acid Based on Late-Stage Decarboxylative Allylic Migration and Biomimetic Aromatization of a Diketo Dioxinone, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol: 2013, Pages: 7604-7610, ISSN: 1434-193X

JOURNAL ARTICLE

Kaliszczak M, Patel H, Kroll SHB, Carroll L, Smith G, Delaney S, Heathcote DA, Bondke A, Fuchter MJ, Coombes RC, Barrett AGM, Ali S, Aboagye EOet al., 2013, Development of a cyclin-dependent kinase inhibitor devoid of ABC transporterdependent drug resistance, BRITISH JOURNAL OF CANCER, Vol: 109, Pages: 2356-2367, ISSN: 0007-0920

JOURNAL ARTICLE

Miyatake-Ondozabal H, Barrett AGM, 2013, Synthetic studies towards tragoponol: preparation of a highly functionalized resorcylate, TETRAHEDRON LETTERS, Vol: 54, Pages: 4817-4820, ISSN: 0040-4039

JOURNAL ARTICLE

Blencowe PS, Barrett AGM, 2012, Synthesis of 6-substituted salicylates via biomimetic aromatization utilizing the cross metathesis of a vinyl dioxinone with homoallylic alcohols, CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, Vol: 90, Pages: 975-984, ISSN: 0008-4042

JOURNAL ARTICLE

Brinkmann C, Barrett AGM, Hill MS, Procopiou PAet al., 2012, Heavier Alkaline Earth Catalysts for the Intermolecular Hydroamination of Vinylarenes, Dienes, and Alkynes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 134, Pages: 2193-2207, ISSN: 0002-7863

JOURNAL ARTICLE

Brinkmann C, Barrett AGM, Hill MS, Procopiou PA, Reidt Set al., 2012, Alkaline Earth Catalysis of Alkynyl Alcohol Hydroalkoxylation/Cyclization, ORGANOMETALLICS, Vol: 31, Pages: 7287-7297, ISSN: 0276-7333

JOURNAL ARTICLE

Cordes J, Calo F, Anderson K, Pfaffeneder T, Laclef S, White AJP, Barrett AGMet al., 2012, Total Syntheses of Angelicoin A, Hericenone J, and Hericenol A via Migratory Prenyl- and Geranylation-Aromatization Sequences, JOURNAL OF ORGANIC CHEMISTRY, Vol: 77, Pages: 652-657, ISSN: 0022-3263

JOURNAL ARTICLE

Cordes J, Laclef S, White AJP, Barrett AGMet al., 2012, Palladium(0)-Catalyzed Allylic Alkylation of Diketoester-Dioxinones with Allyl Acetates under Neutral Conditions: Synthesis of Hexasubstituted Benzene Derivatives, JOURNAL OF ORGANIC CHEMISTRY, Vol: 77, Pages: 3524-3530, ISSN: 0022-3263

JOURNAL ARTICLE

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