Imperial College London
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Professor A G M Barrett, FRS, FMedSci

Faculty of Natural Sciences, Department of Chemistry

Emeritus Professor
 
 
 
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Contact

 

agm.barrett

 
 
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Assistant

 

Ms Virginia Manch +44 (0)20 7594 5767

 
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Location

 

110DCentre House CWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kandela:2017:10.1021/acsmedchemlett.7b00063,
author = {Kandela, IK and McAuliffe, KJ and Cochran, LE and Barrett, AGM and Hoffman, BM and Mazar, AP and Trivedi, ER},
doi = {10.1021/acsmedchemlett.7b00063},
journal = {ACS Medicinal Chemistry Letters},
pages = {705--709},
title = {Discovery of the antitumor effects of a porphyrazine diol (Pz 285) in MDA-MB-231 breast tumor xenograft models in mice},
url = {http://dx.doi.org/10.1021/acsmedchemlett.7b00063},
volume = {8},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A series of porphyrazines (Pzs) with chiral bis-acetal moieties in the β-pyrrole positions ((2R,3R)-2,3-dimethyl-2,3-dimethoxy-1,4-diox-2-ene) have been synthesized and screened as antitumor agents in MDA-MB-231 breast tumor cellsin vitro. The leadPz 285was further tested in a mouse tumor xenograft model with Td-tomato-luc2 fluorescent breast tumor cells (MDA-MB-231 LM24 Her2+) that are highly metastatic to the lungs.Pz 285shows marked antitumor effectsin vivo, with treated mice exhibiting longer median survival that we attribute to smaller primary tumor regrowth after resection and less occurrence of metastasis when compared to vehicle control groups.Pz 285is further compared to the clinically approved chemotherapeutic doxorubicin (Dox). This report lays the groundwork for development of an understudied class of compounds for classical chemotherapy.
AU  - Kandela,IK
AU  - McAuliffe,KJ
AU  - Cochran,LE
AU  - Barrett,AGM
AU  - Hoffman,BM
AU  - Mazar,AP
AU  - Trivedi,ER
DO  - 10.1021/acsmedchemlett.7b00063
EP  - 709
PY  - 2017///
SN  - 1948-5875
SP  - 705
TI  - Discovery of the antitumor effects of a porphyrazine diol (Pz 285) in MDA-MB-231 breast tumor xenograft models in mice
T2  - ACS Medicinal Chemistry Letters
UR  - http://dx.doi.org/10.1021/acsmedchemlett.7b00063
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28740602
UR  - http://hdl.handle.net/10044/1/58266
VL  - 8
ER  -
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