Imperial College London

ProfessorAilsaHart

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Practice
 
 
 
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Contact

 

ailsa.hart

 
 
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Location

 

Northwick ParkNorthwick Park and St Marks Site

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Summary

 

Selected Publications

Journal Articles

Jostins L, Ripke S, Weersma RK, et al., 2012, Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease, Nature, Vol:491, ISSN:0028-0836, Pages:119-124

Hart AL, Plamondon S, Kamm MA, 2007, Topical tacrolimus in the treatment of perianal Crohn's disease: Exploratory randomized controlled trial, Inflammatory Bowel Diseases, Vol:13, ISSN:1078-0998, Pages:245-253

Hart A, Kamm MA, 2002, Review article: mechanisms of initiation and perpetuation of gut inflammation by stress, Alimentary Pharmacology & Therapeutics, Vol:16, ISSN:0269-2813, Pages:2017-2028

Rayner CK, Hart AL, Hayward CMM, et al., 2004, Azathioprine dose escalation in inflammatory bowel disease, Alimentary Pharmacology & Therapeutics, Vol:20, ISSN:0269-2813, Pages:65-71

Despott EJ, Gupta A, Burling D, et al., 2009, Effective dilation of small-bowel strictures by double-balloon enteroscopy in patients with symptomatic Crohn's disease, Gastrointestinal Endoscopy, Vol:70, ISSN:0016-5107, Pages:1030-1036

Bernardo D, Mann ER, Al-Hassi HO, et al., 2013, Lost therapeutic potential of monocyte-derived dendritic cells through lost tissue homing: stable restoration of gut specificity with retinoic acid, Clinical and Experimental Immunology, Vol:174, ISSN:0009-9104, Pages:109-119

Peake STC, Bernardo D, Mann ER, et al., 2013, Mechanisms of Action of Anti-tumor Necrosis Factor a Agents in Crohn's Disease, Inflammatory Bowel Diseases, Vol:19, ISSN:1078-0998, Pages:1546-1555

Al-Hassi HO, Bernardo D, Murugananthan AU, et al., 2013, A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease, Mucosal Immunology, Vol:6, ISSN:1933-0219, Pages:751-761

Mann ER, McCarthy NE, Peake STC, et al., 2012, Skin- and gut-homing molecules on human circulating gamma delta T cells and their dysregulation in inflammatory bowel disease, Clinical and Experimental Immunology, Vol:170, ISSN:0009-9104, Pages:122-130

Bernardo D, Vallejo-Diez S, Mann ER, et al., 2012, IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and Tcells they stimulate, European Journal of Immunology, Vol:42, ISSN:0014-2980, Pages:1337-1353

Siddiqui MRS, Ashrafian H, Tozer P, et al., 2012, A Diagnostic Accuracy Meta-analysis of Endoanal Ultrasound and MRI for Perianal Fistula Assessment, Diseases of the Colon & Rectum, Vol:55, ISSN:0012-3706, Pages:576-585

Katz L, Gisbert JP, Manoogian B, et al., 2012, Doubling the infliximab dose versus halving the infusion intervals in Crohn's disease patients with loss of response, Inflammatory Bowel Diseases, Vol:18, ISSN:1078-0998, Pages:2026-2033

Benjamin J, Hedin C, Koutsoumpas A, et al., 2011, Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota, Inflammatory Bowel Diseases

Hart A, Kamm MA, 1997, An extraordinary cause of megacolon, Lancet, Vol:350

Hart AL, Kellett C, Price C, et al., 1996, Poor recall performance of journal browsing doctors, Lancet, Vol:348

Hart AL, Kamm MA, Knight SC, et al., 2004, Prospective evaluation of intestinal homing memory T cells in ulcerative colitis, Inflammatory Bowel Diseases, Vol:10, ISSN:1078-0998, Pages:496-503

Landy J, Al-Hassi HO, McLaughlin SD, et al., 2011, Review article: faecal transplantation therapy for gastrointestinal disease, Alimentary Pharmacology & Therapeutics, Vol:34, ISSN:0269-2813, Pages:409-415

Hart AL, Kamm MA, Knight SC, et al., 2004, Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls, Clinical and Experimental Immunology, Vol:135, ISSN:0009-9104, Pages:137-145

Benjamin JL, Hedin CRH, Koutsoumpas A, et al., 2011, Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease, Gut, Vol:60, ISSN:0017-5749, Pages:923-929

Hart AL, Stagg AJ, Frame M, et al., 2002, Review article: the role of the gut flora in health and disease, and its modification as therapy, Alimentary Pharmacology & Therapeutics, Vol:16, ISSN:0269-2813, Pages:1383-1393

Stagg AJ, Hart AL, Knight SC, et al., 2003, The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria, Gut, Vol:52, ISSN:0017-5749, Pages:1522-1529

Hart AL, Lammers K, Brigidi P, et al., 2004, Modulation of human dendritic cell phenotype and function by probiotic bacteria, Gut, Vol:53, ISSN:0017-5749, Pages:1602-1609

Hart AL, Al-Hassi HO, Rigby RJ, et al., 2005, Characteristics of intestinal dendritic cells in inflammatory bowel diseases, Gastroenterology, Vol:129, ISSN:0016-5085, Pages:50-65

Ng SC, Hart AL, Kamm MA, et al., 2009, Mechanisms of Action of Probiotics: Recent Advances, Inflammatory Bowel Diseases, Vol:15, ISSN:1078-0998, Pages:300-310

Tozer PJ, Whelan K, Phillips RKS, et al., 2009, Etiology of Perianal Crohn's Disease: Role of Genetic, Microbiological, and Immunological Factors, Inflammatory Bowel Diseases, Vol:15, ISSN:1078-0998, Pages:1591-1598

Ng SC, Plamondon S, Kamm MA, et al., 2010, Immunosuppressive Effects via Human Intestinal Dendritic Cells of Probiotic Bacteria and Steroids in the Treatment of Acute Ulcerative Colitis, Inflammatory Bowel Diseases, Vol:16, ISSN:1078-0998, Pages:1286-1298

Hart AL, Ng SC, Mann E, et al., 2010, Homing of Immune Cells: Role in Homeostasis and Intestinal Inflammation, Inflammatory Bowel Diseases, Vol:16, ISSN:1078-0998, Pages:1969-1977

Tozer PJ, Burling D, Gupta A, et al., 2011, Review article: medical, surgical and radiological management of perianal Crohn's fistulas, Alimentary Pharmacology & Therapeutics, Vol:33, ISSN:0269-2813, Pages:5-22

Ng SC, Benjamin JL, McCarthy NE, et al., 2011, Relationship Between Human Intestinal Dendritic Cells, Gut Microbiota, and Disease Activity in Crohn's Disease, Inflammatory Bowel Diseases, Vol:17, ISSN:1078-0998, Pages:2027-2037

Walker DG, Williams HRT, Kane SP, et al., 2011, Differences in Inflammatory Bowel Disease Phenotype between South Asians and Northern Europeans Living in North West London, UK, American Journal of Gastroenterology, Vol:106, ISSN:0002-9270, Pages:1281-1289

Landy J, Al-Hassi HO, McLaughlin SD, et al., 2012, Etiology of pouchitis, Inflammatory Bowel Diseases, Vol:18, ISSN:1078-0998, Pages:1146-1155

Landy J, Al-Hassi HO, McLaughlin SD, et al., 2010, Review Article: Faecal Transplantation therapy for gastrointestinal diseases.

Tozer PJ, Burling D, Phillips RK, et al., 2010, Review Article: Medical, surgical and radiological management of perianal Crohn’s fistulas.

Hart AL, Ng SC, Mann E, et al., 2010, Immune homing mechanisms – role in immune homeostasis and inflammation .

Hart AL, Ng SC, 2010, Review article: the optimal medical management of acute severe ulcerative colitis, Alimentary Pharmacology & Therapeutics, Vol:32, ISSN:0269-2813, Pages:615-627

Stagg AJ, Hart AL, Kamm MA, et al., 2003, The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria.

Tozer P, Ng SC, Siddiqui MR, et al., 2012, Long-term MRI-guided combined anti-TNF-a and thiopurine therapy for crohn's perianal fistulas, Inflammatory Bowel Diseases, Vol:18, ISSN:1078-0998, Pages:1825-1834

Benjamin JL, Hedin CRH, Koutsoumpas A, et al., 2012, Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota, Inflammatory Bowel Diseases, Vol:18, ISSN:1078-0998, Pages:1092-1100

Mann ER, Bernardo D, Al-Hassi HO, et al., 2012, Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment, Inflammatory Bowel Diseases, Vol:18, ISSN:1078-0998, Pages:1275-1286

Walker DG, Williams HR, Kane SP, et al., 2011, Differences in inflammatory bowel disease phenotype between South Asians and North Europeans lining in North West London.

Ng SC, Benjamin JL, Hedin CRH, et al., 2010, The Relationship between Human Intestinal Dendritic Cells, Gut Microbiota and Disease Activity in Crohn’s Disease.

Benjamin JL, Heddin CRH, Koutsoumpas A, et al., 2010, A randomised, double blind placebo controlled trial of fructo-oligosaccharides in active Crohn’s disease

Hart AL, Omar Al-Hassi H, Kamm MA, et al., 2005, Characteristics of intestinal dendritic cells in inflammatory bowel diseases

Hart AL, Kamm MA, Knight S, et al., 2004, Prospective evaluation of intestinal homing memory T cells in ulcerative colitis.

Hart AL, Kamm MA, Knight S, et al., 2004, Quantitative and functional characteristics of intestinal homing memory T-cells: analysis of Crohn’s disease patients and healthy controls.

Kellet CF, Hart AL, Price CJ, et al., 1996, Poor recall performance of journal-browsing doctors

Books

Hart AL, Ng SC, 2011, Inflammatory Bowel Disease, T.F.M. Publications, ISBN:9781903378823

Hart AL, 2002, Gut ecology, Informa HealthCare, ISBN:9781841841397

Conference

Walker DG, Williams HRT, Padaruth S, et al., 2009, INFLAMMATORY BOWEL DISEASE IN CAUCASIAN AND UK SOUTH ASIAN PATIENTS: DIFFERENCE IN CLINICAL PHENOTYPE, Annual Meeting of the British-Society-of-Gastroenterology, B M J PUBLISHING GROUP, Pages:A60-A60, ISSN:0017-5749

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