Imperial College London

DrAlexPechlivanis

Faculty of MedicineDepartment of Surgery & Cancer

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 1698alexandros.pechlivanis

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

20 results found

Allegretti JR, Mullish BH, Bogart E, Shu E, Dong X, McDonald JAK, Pechlivanis A, Marchesi JR, Gerber G, Bry Let al., 2018, 25 - Microbiome and metabolic markers of Clostridium Difficile recurrance, Digestive Diseases Week, Publisher: Elsevier, Pages: S8-S9, ISSN: 0016-5085

CONFERENCE PAPER

McDonald JAK, Mullish BH, Pechlivanis A, Li JV, Nicholson JK, Holmes E, Thursz MR, Marchesi JRet al., 2018, 24 - A novel route to controlling Clostridioides Difficile growth via short chain fatty acid and bile acid modulation, Digestive Diseases Week, Publisher: Elsevier, Pages: S8-S8, ISSN: 0016-5085

CONFERENCE PAPER

Mullish BH, Pechlivanis A, Barker GF, Thursz MR, Marchesi JR, McDonald JAKet al., 2018, Functional microbiomics: Evaluation of gut microbiota-bile acid metabolism interactions in health and disease., Methods

There is an ever-increasing recognition that bile acids are not purely simple surfactant molecules that aid in lipid digestion, but are a family of molecules contributing to a diverse range of key systemic functions in the host. It is now also understood that the specific composition of the bile acid milieu within the host is related to the expression and activity of bacterially-derived enzymes within the gastrointestinal tract, as such creating a direct link between the physiology of the host and the gut microbiota. Coupled to the knowledge that perturbation of the structure and/or function of the gut microbiota may contribute to the pathogenesis of a range of diseases, there is a high level of interest in the potential for manipulation of the gut microbiota-host bile acid axis as a novel approach to therapeutics. Much of the growing understanding of the biology of this area reflects the recent development and refinement of a range of novel techniques; this study applies a number of those techniques to the analysis of human samples, aiming to illustrate their strengths, drawbacks and biological significance at all stages. Specifically, we used microbial profiling (using 16S rRNA gene sequencing), bile acid profiling (using liquid chromatography-mass spectrometry), bsh and baiCD qPCR, and a BSH enzyme activity assay to demonstrate differences in the gut microbiota and bile metabolism in stool samples from healthy and antibiotic-exposed individuals.

JOURNAL ARTICLE

van Golen RF, Olthof PB, de Haan LR, Coelen RJ, Pechlivanis A, de Keijzer MJ, Weijer R, de Waart DR, van Kuilenburg ABP, Roelofsen J, Gilijamse PW, Maas MA, Lewis MR, Nicholson JK, Verheij J, Heger Met al., 2018, The pathophysiology of human obstructive cholestasis is mimicked in cholestatic Gold Syrian hamsters, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, Vol: 1864, Pages: 942-951, ISSN: 0925-4439

JOURNAL ARTICLE

Hegade VS, Pechlivanis A, McDonald JA, Rees DN, Corrigan M, Hirschfield GM, Taylor-Robinson SD, Holmes E, Marchesi JR, Kendrick S, Jones Det al., 2017, Serum Metabonomic and Gut Microbial Profile in Patients with Primary Biliary Cholangitis with Pruritus and the Effect of Ileal Bile Acid Transporter Inhibition, 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Publisher: WILEY, Pages: 171A-171A, ISSN: 0270-9139

CONFERENCE PAPER

Michael DR, Davies TS, Moss JWE, Calvente DL, Ramji DP, Marchesi JR, Pechlivanis A, Plummer SF, Hughes TRet al., 2017, The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Millar B, Richardson C, Mckay K, Pechlivanis A, Innes B, Kirby J, Jones D, Holmes E, Oakley Fet al., 2017, Obeticholic acid therapy improves cognitive decline in cholestatic liver disease, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S364-S365, ISSN: 0168-8278

CONFERENCE PAPER

Mullish BH, McDonald JA, Kao DH, Allegretti JR, Petrof EO, Pechlivanis A, Atkinson SR, Williams HR, Thursz MR, Marchesi Jet al., 2017, UNDERSTANDING THE MECHANISMS OF EFFICACY OF FECAL MICROBIOTA TRANSPLANTATION IN THE TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTION: THE POTENTIAL ROLE OF BILE-METABOLISING ENZYMES, Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S47-S47, ISSN: 0016-5085

CONFERENCE PAPER

Mullish BH, McDonald JAK, Kao DH, Allegretti JR, Petrof EO, Pechlivanis A, Barker GF, Atkinson SR, Williams HRT, Thursz MR, Marchesi JRet al., 2017, GUT MICROBIOTA-HOST BILE ACID METABOLISM INTERACTIONS IN CLOSTRIDIUM DIFFICILE INFECTION: THE EXPLANATION FOR THE EFFICACY OF FAECAL MICROBIOTA TRANSPLANTATION?, Annual General Meeting of the British-Society-of-Gastroenterology (BSG), Publisher: BMJ PUBLISHING GROUP, Pages: A33-A34, ISSN: 0017-5749

CONFERENCE PAPER

Mullish BH, McDonald JAK, Pechlivanis A, Rees DN, Williams HRT, Marchesi JR, Thursz MRet al., 2016, UNDERSTANDING THE EFFICACY OF FAECAL MICROBIOTA TRANSPLANTATION IN CLOSTRIDIUM DIFFICILE INFECTION: RE-ESTABLISHMENT OF GUT MICROBIOTA WITH THE ABILITY TO DEGRADE BILE?, Publisher: BMJ PUBLISHING GROUP, Pages: A184-A184, ISSN: 0017-5749

CONFERENCE PAPER

Zafeiridis A, Chatziioannou AC, Sarivasiliou H, Kyparos A, Nikolaidis MG, Vrabas IS, Pechlivanis A, Zoumpoulakis P, Baskakis C, Dipla K, Theodoridis GAet al., 2016, Global Metabolic Stress of Isoeffort Continuous and High Intensity Interval Aerobic Exercise: A Comparative H-1 NMR Metabonomic Study, JOURNAL OF PROTEOME RESEARCH, Vol: 15, Pages: 4452-4463, ISSN: 1535-3893

JOURNAL ARTICLE

Pechlivanis A, Papaioannou KG, Tsalis G, Saraslanidis P, Mougios V, Theodoridis GAet al., 2015, Monitoring the Response of the Human Urinary Metabolome to Brief Maximal Exercise by a Combination of RP-UPLC-MS and H-1 NMR Spectroscopy, JOURNAL OF PROTEOME RESEARCH, Vol: 14, Pages: 4610-4622, ISSN: 1535-3893

JOURNAL ARTICLE

Sarafian MH, Lewis MR, Pechlivanis A, Ralphs S, McPhail MJW, Patel VC, Dumas M-E, Holmes E, Nicholson JKet al., 2015, Bile Acid Profiling and Quantification in Biofluids Using Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry, ANALYTICAL CHEMISTRY, Vol: 87, Pages: 9662-9670, ISSN: 0003-2700

JOURNAL ARTICLE

Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Pechlivanis A, Gooderham NJet al., 2015, Aspartame Sensitivity? A Double Blind Randomised Crossover Study (vol 10, e0116212, 2015), PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Pechlivanis A, Gooderham NJ, Holmes E, le Roux CW, Atkin SL, Courts Fet al., 2015, Aspartame Sensitivity? A Double Blind Randomised Crossover Study, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Pechlivanis A, Chatziioannou AC, Veskoukis AS, Kouretas D, Mougios V, Theodoridis GAet al., 2014, GC-MS analysis of blood for the metabonomic investigation of the effects of physical exercise and allopurinol administration on rats, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Vol: 966, Pages: 127-131, ISSN: 1570-0232

JOURNAL ARTICLE

Ypsilantis P, Lambropoulou M, Kourkoutas I, Pechlivanis A, Simopoulos Cet al., 2014, Liver radiofrequency ablation compromises the biological gut barrier, HUMAN & EXPERIMENTAL TOXICOLOGY, Vol: 33, Pages: 64-73, ISSN: 0960-3271

JOURNAL ARTICLE

Hosnijeh FS, Pechlivanis A, Keun HC, Portengen L, Bueno-de-Mesquita HB, Heederik D, Vermeulen Ret al., 2013, Serum metabolomic pertubations among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Vol: 54, Pages: 558-565, ISSN: 0893-6692

JOURNAL ARTICLE

Pechlivanis A, Kostidis S, Saraslanidis P, Petridou A, Tsalis G, Veselkov K, Mikros E, Mougios V, Theodoridis GAet al., 2013, H-1 NMR Study on the Short- and Long-Term Impact of Two Training Programs of Sprint Running on the Metabolic Fingerprint of Human Serum, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 470-480, ISSN: 1535-3893

JOURNAL ARTICLE

Pechlivanis A, Kostidis S, Saraslanidis P, Petridou A, Tsalis G, Mougios V, Gika HG, Mikros E, Theodoridis GAet al., 2010, H-1 NMR-Based Metabonomic Investigation of the Effect of Two Different Exercise Sessions on the Metabolic Fingerprint of Human Urine, JOURNAL OF PROTEOME RESEARCH, Vol: 9, Pages: 6405-6416, ISSN: 1535-3893

JOURNAL ARTICLE

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