190 results found
Atkin W, Wooldrage K, Brenner A, et al., 2017, Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study, LANCET ONCOLOGY, Vol: 18, Pages: 823-834, ISSN: 1470-2045
Atkin W, Wooldrage K, Parkin DM, et al., 2017, Long-term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial, LANCET, Vol: 389, Pages: 1299-1311, ISSN: 0140-6736
Atkin W, Wooldrage K, Sasieni P, et al., 2017, Colorectal adenomas, surveillance, and cancer - Authors' reply., Lancet Oncol, Vol: 18
Atkin W, Wooldrage K, Sasieni P, et al., 2017, Colorectal adenomas, surveillance, and cancer, LANCET ONCOLOGY, Vol: 18, Pages: E428-E428, ISSN: 1470-2045
Brown JP, Wooldrage K, Wright S, et al., 2017, High test positivity and low positive predictive value for colorectal cancer of continued faecal occult blood test screening after negative colonoscopy., J Med Screen
Objectives The English Bowel Cancer Screening Programme offers biennial guaiac faecal occult blood test (gFOBT) screening to 60-74-year-olds. Participants with positive results are referred for follow-up, but many do not have significant findings. If they remain age eligible, these individuals are reinvited for gFOBT screening. We evaluated the performance of repeat screening in this group. Methods We analysed data on programme participants reinvited to gFOBT screening after either previous negative gFOBT ( n = 327,542), or positive gFOBT followed by a diagnostic investigation negative for colorectal cancer (CRC) or adenomas requiring surveillance ( n = 42,280). Outcomes calculated were uptake, test positivity, yield of CRC, and positive predictive value (PPV) of gFOBT for CRC. Results For participants with a previous negative gFOBT, uptake in the subsequent screening round was 87.5%, positivity was 1.3%, yield of CRC was 0.112% of those adequately screened, and the PPV of gFOBT for CRC was 9.1%. After a positive gFOBT and a negative diagnostic investigation, uptake in the repeat screening round was 82.6%, positivity was 11.3%, CRC yield was 0.172% of participants adequately screened, and the PPV of gFOBT for CRC was 1.7%. Conclusion With high positivity and low PPV for CRC, the suitability of routine repeat gFOBT screening in two years among individuals with a previous positive test and a negative diagnostic examination needs to be carefully considered.
Cheung W, Keski-Rahkonen P, Assi N, et al., 2017, A metabolomic study of biomarkers of meat and fish intake, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 105, Pages: 600-608, ISSN: 0002-9165
Freisling H, Noh H, Slimani N, et al., 2017, Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study., Eur J Nutr
PURPOSE: There is inconsistent evidence regarding the relationship between higher intake of nuts, being an energy-dense food, and weight gain. We investigated the relationship between nut intake and changes in weight over 5 years. METHODS: This study includes 373,293 men and women, 25-70 years old, recruited between 1992 and 2000 from 10 European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Habitual intake of nuts including peanuts, together defined as nut intake, was estimated from country-specific validated dietary questionnaires. Body weight was measured at recruitment and self-reported 5 years later. The association between nut intake and body weight change was estimated using multilevel mixed linear regression models with center/country as random effect and nut intake and relevant confounders as fixed effects. The relative risk (RR) of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to baseline body mass index (BMI). RESULTS: On average, study participants gained 2.1 kg (SD 5.0 kg) over 5 years. Compared to non-consumers, subjects in the highest quartile of nut intake had less weight gain over 5 years (-0.07 kg; 95% CI -0.12 to -0.02) (P trend = 0.025) and had 5% lower risk of becoming overweight (RR 0.95; 95% CI 0.92-0.98) or obese (RR 0.95; 95% CI 0.90-0.99) (both P trend <0.008). CONCLUSIONS: Higher intake of nuts is associated with reduced weight gain and a lower risk of becoming overweight or obese.
Gunter MJ, Murphy N, Cross AJ, et al., 2017, Coffee Drinking and Mortality in 10 European Countries A Multinational Cohort Study, ANNALS OF INTERNAL MEDICINE, Vol: 167, Pages: 236-+, ISSN: 0003-4819
Gupta S, Jacobs ET, Baron JA, et al., 2017, Risk stratification of individuals with low-risk colorectal adenomas using clinical characteristics: a pooled analysis., Gut, Vol: 66, Pages: 446-453
OBJECTIVE: For individuals with 1-2 small (<1 cm) low-risk colorectal adenomas, international guidelines range from no surveillance to offering surveillance colonoscopy in 5-10 years. We hypothesised that the risks for metachronous advanced neoplasia (AN) among patients with low-risk adenomas differ based on clinical factors distinct from those currently used. DESIGN: We pooled data from seven prospective studies to assess the risk of metachronous AN. Two groups with 1-2 small adenomas were defined based on guidelines from the UK (n=4516) or the European Union (EU)/US (n=2477). RESULTS: Absolute risk of metachronous AN ranged from a low of 2.9% to a high of 12.2%, depending on specific risk factor and guideline used. For the UK group, the highest absolute risks for metachronous AN were found among individuals with a history of prior polyp (12.2%), villous histology (12.2%), age ≥70 years (10.9%), high-grade dysplasia (10.9%), any proximal adenoma (10.2%), distal and proximal adenoma (10.8%) or two adenomas (10.1%). For the EU/US group, the highest absolute risks for metachronous AN were among individuals with a history of prior polyp (11.5%) or the presence of both proximal and distal adenomas (11.0%). In multivariate analyses, strong associations for increasing age and history of prior polyps and odds of metachronous AN were observed, whereas more modest associations were shown for baseline proximal adenomas and those with villous features. CONCLUSIONS: Risks of metachronous AN among individuals with 1-2 small adenomas vary according to readily available clinical characteristics. These characteristics may be considered for recommending colonoscopy surveillance and require further investigation.
Jay R, Brennan P, Brenner, et al., 2017, Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559., Urol Oncol, Vol: 35
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment vs. the light drinkers category were 0.78 (0.62-0.99), 0.82 (0.64-1.04), 0.70 (0.55-0.90), and 0.91 (0.63-1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
Lu Y, Zamora-Ros R, Chan S, et al., 2017, Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)., Inflammatory Bowel Diseases, Vol: 23, Pages: 2072-2082, ISSN: 1078-0998
BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC. RESULTS: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance. CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.
Meidtner K, Podmore C, Kröger J, et al., 2017, Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study., Diabetes Care
OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS: The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. RESULTS: Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03). CONCLUSIONS: We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.
Molina-Montes E, Sanchez M-J, Buckland G, et al., 2017, Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort, BRITISH JOURNAL OF CANCER, Vol: 116, Pages: 811-820, ISSN: 0007-0920
Murphy G, Cross AJ, Dawsey SM, et al., 2017, Serum ghrelin is associated with risk of colorectal adenocarcinomas in the ATBC study., Gut
BACKGROUND: Colorectal cancers are the third most common cancers in women and men in the USA. While dietary and lifestyle factors such as Western diet, physical inactivity and obesity have been linked to an increased risk of this malignancy, the mechanisms for these associations are unclear. GI hormones, including ghrelin, are involved in energy balance by mediating appetite and metabolism; however, the association between ghrelin and colorectal cancer has not been studied. METHODS: We conducted a case-control study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish smokers (aged 50-69 years) to examine serum ghrelin concentration and colorectal cancer risk. Data from 284 colon and 239 rectal cancers and 523 controls (matched on age, date of blood draw and serum availability) were analysed. ORs and 95% CIs were calculated using multivariable (conditional) logistic regression. RESULTS: Overall, low-serum ghrelin was significantly associated with increased risk of colorectal cancer (Q1 vs Q4: OR:1.57, 95% CI 1.05 to 2.34). For individuals developing tumours within 10 years of blood draw, those in the lowest quartile of serum ghrelin concentrations were statistically significantly more likely to develop colorectal cancers than those with higher serum ghrelin concentrations (OR: 10.86, 95% CI 5.01 to 23.55). However, for individuals with tumours developing more than 20 years after blood draw, low-serum ghrelin concentrations were associated with a decreased risk of colorectal cancer relative to those with the highest serum ghrelin concentrations (OR: 0.26, 95% CI 0.11 to 0.64). CONCLUSION: Low-serum ghrelin was associated with an increased colorectal cancer risk within 10 years of blood draw with a decreased risk for developing colorectal cancer more than 20 years after blood draw. These results suggest that ghrelin concentrations may vary across the carcinogenic process.
Perez-Cornago A, Travis RC, Appleby PN, et al., 2017, Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC), INTERNATIONAL JOURNAL OF CANCER, Vol: 141, Pages: 287-297, ISSN: 0020-7136
Sawada N, Wark PA, Merritt MA, et al., 2017, The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC), PLOS ONE, Vol: 12, ISSN: 1932-6203
Schmidt JA, Fensom GK, Rinaldi S, et al., 2017, Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition, BMC MEDICINE, Vol: 15, ISSN: 1741-7015
Stepien M, Hughes DJ, Hybsier S, et al., 2017, Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans, BRITISH JOURNAL OF CANCER, Vol: 116, Pages: 688-696, ISSN: 0007-0920
Stepien M, Jenab M, Freisling H, et al., 2017, Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort, CARCINOGENESIS, Vol: 38, Pages: 699-707, ISSN: 0143-3334
Zamora-Ros R, Barupal DK, Rothwell JA, et al., 2017, Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort, INTERNATIONAL JOURNAL OF CANCER, Vol: 140, Pages: 1836-1844, ISSN: 0020-7136
Zamora-Ros R, Castaneda J, Rinaldi S, et al., 2017, Consumption of Fish Is Not Associated with Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study, JOURNAL OF NUTRITION, Vol: 147, Pages: 1366-1373, ISSN: 0022-3166
Chuang S-C, Boeing H, Vollset SE, et al., 2016, Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study, IMMUNITY & AGEING, Vol: 13, ISSN: 1742-4933
Duarte-Salles T, Misra S, Stepien M, et al., 2016, Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population, CANCER PREVENTION RESEARCH, Vol: 9, Pages: 758-765, ISSN: 1940-6207
Hughes DJ, Duarte-Salles T, Hybsier S, et al., 2016, Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort, AMERICAN JOURNAL OF CLINICAL NUTRITION, Vol: 104, Pages: 406-414, ISSN: 0002-9165
Inoue-Choi M, Virk-Baker MK, Aschebrook-Kilfoy B, et al., 2016, Development and calibration of a dietary nitrate and nitrite database in the NIH-AARP Diet and Health Study, PUBLIC HEALTH NUTRITION, Vol: 19, Pages: 1934-1943, ISSN: 1368-9800
Kong SY, Hao QT, Gewirtz AT, et al., 2016, Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 25, Pages: 291-301, ISSN: 1055-9965
Liu L, Messer K, Baron JA, et al., 2016, A prognostic model for advanced colorectal neoplasia recurrence, CANCER CAUSES & CONTROL, Vol: 27, Pages: 1175-1185, ISSN: 0957-5243
Lu Y, Cross AJ, Murphy N, et al., 2016, Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort, CANCER CAUSES & CONTROL, Vol: 27, Pages: 919-927, ISSN: 0957-5243
Molina-Montes E, Sanchez M-J, Zamora-Ros R, et al., 2016, Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort, INTERNATIONAL JOURNAL OF CANCER, Vol: 139, Pages: 1480-1492, ISSN: 0020-7136
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