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BibTex format

@article{Murphy:2018:10.1002/ijc.31563,
author = {Murphy, N and Achaintre, D and Zamora-Ros, R and Jenab, M and Boutron-Ruault, M-C and Carbonnel, F and Savoye, I and Kaaks, R and Kühn, T and Boeing, H and Aleksandrova, K and Tjønneland, A and Kyrø, C and Overvad, K and Quirós, JR and Sánchez, M-J and Altzibar, JM and María, Huerta J and Barricarte, A and Khaw, K-T and Bradbury, KE and Perez-Cornago, A and Trichopoulou, A and Karakatsani, A and Peppa, E and Palli, D and Grioni, S and Tumino, R and Sacerdote, C and Panico, S and Bueno-de-Mesquita, B and Peeters, PH and Rutegård, M and Johansson, I and Freisling, H and Noh, H and Cross, AJ and Vineis, P and Tsilidis, K and Gunter, MJ and Scalbert, A},
doi = {10.1002/ijc.31563},
journal = {International Journal of Cancer},
pages = {1620--1631},
title = {A prospective evaluation of plasma polyphenol levels and colon cancer risk},
url = {http://dx.doi.org/10.1002/ijc.31563},
volume = {143},
year = {2018}
}

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TY  - JOUR
AB  - Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95%CI]=0.79-0.93; qvalue =0.01) and homovanillic acid (OR per log2 -value, 1.46, 95%CI=1.16-1.84; qvalue =0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR=0.61, 95%CI=0.41-0.91, ptrend =0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR=1.72, 95%CI=1.17-2.53, ptrend <0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk, of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis. This article is protected by copyright. All rights reserved.
AU  - Murphy,N
AU  - Achaintre,D
AU  - Zamora-Ros,R
AU  - Jenab,M
AU  - Boutron-Ruault,M-C
AU  - Carbonnel,F
AU  - Savoye,I
AU  - Kaaks,R
AU  - Kühn,T
AU  - Boeing,H
AU  - Aleksandrova,K
AU  - Tjønneland,A
AU  - Kyrø,C
AU  - Overvad,K
AU  - Quirós,JR
AU  - Sánchez,M-J
AU  - Altzibar,JM
AU  - María,Huerta J
AU  - Barricarte,A
AU  - Khaw,K-T
AU  - Bradbury,KE
AU  - Perez-Cornago,A
AU  - Trichopoulou,A
AU  - Karakatsani,A
AU  - Peppa,E
AU  - Palli,D
AU  - Grioni,S
AU  - Tumino,R
AU  - Sacerdote,C
AU  - Panico,S
AU  - Bueno-de-Mesquita,B
AU  - Peeters,PH
AU  - Rutegård,M
AU  - Johansson,I
AU  - Freisling,H
AU  - Noh,H
AU  - Cross,AJ
AU  - Vineis,P
AU  - Tsilidis,K
AU  - Gunter,MJ
AU  - Scalbert,A
DO  - 10.1002/ijc.31563
EP  - 1631
PY  - 2018///
SN  - 0020-7136
SP  - 1620
TI  - A prospective evaluation of plasma polyphenol levels and colon cancer risk
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.31563
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29696648
UR  - http://hdl.handle.net/10044/1/59736
VL  - 143
ER  -

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