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@article{Ambatipudi:2017:10.1016/j.ejca.2017.01.014,
author = {Ambatipudi, S and Horvath, S and Perrier, F and Cuenin, C and Hernandez-Vargas, H and Le, Calvez-Kelm F and Durand, G and Byrnes, G and Ferrari, P and Bouaoun, L and Sklias, A and Chajes, V and Overvad, K and Severi, G and Baglietto, L and Clavel-Chapelon, F and Kaaks, R and Barrdah, M and Boeing, H and Trichopoulou, A and Lagiou, P and Naska, A and Masala, G and Agnoli, C and Polidoro, S and Tumino, R and Panico, S and Dollé, M and Peeters, PHM and Onland-Moret, NC and Sandanger, TM and Nøst, TH and Weiderpass, Vainio E and Ramón, Quirós J and Agudo, A and Rodriguez-Barranco, M and Huerta, Castaño JM and Barricarte, A and Matheu, Fernández A and Travis, RC and Vineis, P and Muller, DC and Riboli, E and Gunter, M and Romieu, I and Herceg, Z},
doi = {10.1016/j.ejca.2017.01.014},
journal = {European Journal of Cancer},
pages = {299--307},
title = {DNA methylome analysis identifies accelerated epigenetic aging associated with postmenopausal breast cancer susceptibility},
url = {http://dx.doi.org/10.1016/j.ejca.2017.01.014},
volume = {75},
year = {2017}
}

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TY  - JOUR
AB  - Aim of the studyA vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as ‘epigenetic clock’, has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based biomarkers for risk stratification.MethodsHere, we profiled DNA methylation changes in a nested case–control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (n = 960) using the Illumina HumanMethylation 450K BeadChip arrays and used the Horvath age estimation method to calculate epigenetic age for these samples. Intrinsic epigenetic age acceleration (IEAA) was estimated as the residuals by regressing epigenetic age on chronological age.ResultsWe observed an association between IEAA and breast cancer risk (OR, 1.04; 95% CI, 1.007–1.076, P = 0.016). One unit increase in IEAA was associated with a 4% increased odds of developing breast cancer (OR, 1.04; 95% CI, 1.007–1.076). Stratified analysis based on menopausal status revealed that IEAA was associated with development of postmenopausal breast cancers (OR, 1.07; 95% CI, 1.020–1.11, P = 0.003). In addition, methylome-wide analyses revealed that a higher mean DNA methylation at cytosine-phosphate-guanine (CpG) islands was associated with increased risk of breast cancer development (OR per 1 SD = 1.20; 95 %CI: 1.03–1.40, P = 0.02) whereas mean methylation levels at non-island CpGs were indistinguishable between cancer cases and controls.ConclusionEpigenetic age acceleration and CpG island methylation have a weak, but statistically significant, association with breast cancer susceptibility.
AU  - Ambatipudi,S
AU  - Horvath,S
AU  - Perrier,F
AU  - Cuenin,C
AU  - Hernandez-Vargas,H
AU  - Le,Calvez-Kelm F
AU  - Durand,G
AU  - Byrnes,G
AU  - Ferrari,P
AU  - Bouaoun,L
AU  - Sklias,A
AU  - Chajes,V
AU  - Overvad,K
AU  - Severi,G
AU  - Baglietto,L
AU  - Clavel-Chapelon,F
AU  - Kaaks,R
AU  - Barrdah,M
AU  - Boeing,H
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Naska,A
AU  - Masala,G
AU  - Agnoli,C
AU  - Polidoro,S
AU  - Tumino,R
AU  - Panico,S
AU  - Dollé,M
AU  - Peeters,PHM
AU  - Onland-Moret,NC
AU  - Sandanger,TM
AU  - Nøst,TH
AU  - Weiderpass,Vainio E
AU  - Ramón,Quirós J
AU  - Agudo,A
AU  - Rodriguez-Barranco,M
AU  - Huerta,Castaño JM
AU  - Barricarte,A
AU  - Matheu,Fernández A
AU  - Travis,RC
AU  - Vineis,P
AU  - Muller,DC
AU  - Riboli,E
AU  - Gunter,M
AU  - Romieu,I
AU  - Herceg,Z
DO  - 10.1016/j.ejca.2017.01.014
EP  - 307
PY  - 2017///
SN  - 0014-2964
SP  - 299
TI  - DNA methylome analysis identifies accelerated epigenetic aging associated with postmenopausal breast cancer susceptibility
T2  - European Journal of Cancer
UR  - http://dx.doi.org/10.1016/j.ejca.2017.01.014
UR  - http://hdl.handle.net/10044/1/44191
VL  - 75
ER  -

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