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@article{Stepien:2017:10.1038/bjc.2017.1,
author = {Stepien, M and Hughes, DJ and Hybsier, S and Bamia, C and Tjonneland, A and Overvad, K and Affret, A and His, M and Boutron-Ruault, M-C and Katzke, V and Kuehn, T and Aleksandrova, K and Trichopoulou, A and Lagiou, P and Orfanos, P and Palli, D and Sieri, S and Tumino, R and Ricceri, F and Panico, S and Bueno-de-Mesquita, HBA and Peeters, PH and Weiderpass, E and Lasheras, C and Bonet, Bonet C and Molina-Portillo, E and Dorronsoro, M and Maria, Huerta J and Barricarte, A and Ohlsson, B and Sjoberg, K and Werner, M and Shungin, D and Wareham, N and Khaw, K-T and Travis, RC and Freisling, H and Cross, AJ and Schomburg, L and Jenab, M},
doi = {10.1038/bjc.2017.1},
journal = {British Journal of Cancer},
pages = {688--696},
title = {Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans},
url = {http://dx.doi.org/10.1038/bjc.2017.1},
volume = {116},
year = {2017}
}

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TY  - JOUR
AB  - background:  Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.methods:  A nested case–control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk.results:  For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13–0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45–2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41–15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed.conclusions:  Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
AU  - Stepien,M
AU  - Hughes,DJ
AU  - Hybsier,S
AU  - Bamia,C
AU  - Tjonneland,A
AU  - Overvad,K
AU  - Affret,A
AU  - His,M
AU  - Boutron-Ruault,M-C
AU  - Katzke,V
AU  - Kuehn,T
AU  - Aleksandrova,K
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Orfanos,P
AU  - Palli,D
AU  - Sieri,S
AU  - Tumino,R
AU  - Ricceri,F
AU  - Panico,S
AU  - Bueno-de-Mesquita,HBA
AU  - Peeters,PH
AU  - Weiderpass,E
AU  - Lasheras,C
AU  - Bonet,Bonet C
AU  - Molina-Portillo,E
AU  - Dorronsoro,M
AU  - Maria,Huerta J
AU  - Barricarte,A
AU  - Ohlsson,B
AU  - Sjoberg,K
AU  - Werner,M
AU  - Shungin,D
AU  - Wareham,N
AU  - Khaw,K-T
AU  - Travis,RC
AU  - Freisling,H
AU  - Cross,AJ
AU  - Schomburg,L
AU  - Jenab,M
DO  - 10.1038/bjc.2017.1
EP  - 696
PY  - 2017///
SN  - 1532-1827
SP  - 688
TI  - Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
T2  - British Journal of Cancer
UR  - http://dx.doi.org/10.1038/bjc.2017.1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000395696200017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/45839
VL  - 116
ER  -

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