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@article{Stepien:2017:carcin/bgx051,
author = {Stepien, M and Jenab, M and Freisling, H and Becker, N-P and Czuban, M and Tjonneland, A and Olsen, A and Overvad, K and Boutron-Ruault, M-C and Mancini, FR and Savoye, I and Katzke, V and Kuehn, T and Boeing, H and Iqbal, K and Trichopoulou, A and Bamia, C and Orfanos, P and Palli, D and Sieri, S and Tumino, R and Naccarati, A and Panico, S and Bueno-de-Mesquita, HBA and Peeters, PH and Weiderpass, E and Merino, S and Jakszyn, P and Sanchez, M-J and Dorronsoro, M and Huerta, JM and Barricarte, A and Boden, S and van, Guelpen B and Wareham, N and Khaw, K-T and Bradbury, KE and Cross, AJ and Schomburg, L and Hughes, DJ},
doi = {carcin/bgx051},
journal = {Carcinogenesis},
pages = {699--707},
title = {Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort},
url = {http://dx.doi.org/10.1093/carcin/bgx051},
volume = {38},
year = {2017}
}

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TY  - JOUR
AB  - Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/zinc ratio levels in CRC development and progression.
AU  - Stepien,M
AU  - Jenab,M
AU  - Freisling,H
AU  - Becker,N-P
AU  - Czuban,M
AU  - Tjonneland,A
AU  - Olsen,A
AU  - Overvad,K
AU  - Boutron-Ruault,M-C
AU  - Mancini,FR
AU  - Savoye,I
AU  - Katzke,V
AU  - Kuehn,T
AU  - Boeing,H
AU  - Iqbal,K
AU  - Trichopoulou,A
AU  - Bamia,C
AU  - Orfanos,P
AU  - Palli,D
AU  - Sieri,S
AU  - Tumino,R
AU  - Naccarati,A
AU  - Panico,S
AU  - Bueno-de-Mesquita,HBA
AU  - Peeters,PH
AU  - Weiderpass,E
AU  - Merino,S
AU  - Jakszyn,P
AU  - Sanchez,M-J
AU  - Dorronsoro,M
AU  - Huerta,JM
AU  - Barricarte,A
AU  - Boden,S
AU  - van,Guelpen B
AU  - Wareham,N
AU  - Khaw,K-T
AU  - Bradbury,KE
AU  - Cross,AJ
AU  - Schomburg,L
AU  - Hughes,DJ
DO  - carcin/bgx051
EP  - 707
PY  - 2017///
SN  - 1460-2180
SP  - 699
TI  - Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
T2  - Carcinogenesis
UR  - http://dx.doi.org/10.1093/carcin/bgx051
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406237300004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49536
VL  - 38
ER  -

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