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@article{Jakszyn:2017:10.1002/ijc.30797,
author = {Jakszyn, P and Fonseca-Nunes, A and Lujan-Barroso, L and Aranda, N and Tous, M and Arija, V and Cross, A and Bueno-de-Mesquita, HBA and Weiderpass, E and Kuehn, T and Kaaks, R and Sjoeberg, K and Ohlsson, B and Tumino, R and Palli, D and Ricceri, F and Fasanelli, F and Krogh, V and Mattiello, A and Jenab, M and Gunter, M and Perez-Cornago, A and Khaw, K-T and Tjonneland, A and Olsen, A and Overvad, K and Trichopoulou, A and Peppa, E and Vasilopoulou, E and Boeing, H and Sanchez-Cantalejo, E and Maria, Huerta J and Dorronsoro, M and Barricarte, A and Maria, Quiros J and Peeters, PH and Agudo, A},
doi = {10.1002/ijc.30797},
journal = {International Journal of Cancer},
pages = {945--951},
title = {Hepcidin levels and gastric cancer risk in the EPIC-EurGast study},
url = {http://dx.doi.org/10.1002/ijc.30797},
volume = {141},
year = {2017}
}

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TY  - JOUR
AB  - Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l = 0.96, 95% CI = 0.93–0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: −69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis.
AU  - Jakszyn,P
AU  - Fonseca-Nunes,A
AU  - Lujan-Barroso,L
AU  - Aranda,N
AU  - Tous,M
AU  - Arija,V
AU  - Cross,A
AU  - Bueno-de-Mesquita,HBA
AU  - Weiderpass,E
AU  - Kuehn,T
AU  - Kaaks,R
AU  - Sjoeberg,K
AU  - Ohlsson,B
AU  - Tumino,R
AU  - Palli,D
AU  - Ricceri,F
AU  - Fasanelli,F
AU  - Krogh,V
AU  - Mattiello,A
AU  - Jenab,M
AU  - Gunter,M
AU  - Perez-Cornago,A
AU  - Khaw,K-T
AU  - Tjonneland,A
AU  - Olsen,A
AU  - Overvad,K
AU  - Trichopoulou,A
AU  - Peppa,E
AU  - Vasilopoulou,E
AU  - Boeing,H
AU  - Sanchez-Cantalejo,E
AU  - Maria,Huerta J
AU  - Dorronsoro,M
AU  - Barricarte,A
AU  - Maria,Quiros J
AU  - Peeters,PH
AU  - Agudo,A
DO  - 10.1002/ijc.30797
EP  - 951
PY  - 2017///
SN  - 0020-7136
SP  - 945
TI  - Hepcidin levels and gastric cancer risk in the EPIC-EurGast study
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.30797
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404842200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/52745
VL  - 141
ER  -

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