Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aleksandrova:2017:aje/kww194,
author = {Aleksandrova, K and Schlesinger, S and Fedirko, V and Jenab, M and Bueno-de-Mesquita, B and Freisling, H and Romieu, I and Pischon, T and Kaaks, R and Gunter, MJ and Dahm, CC and Overvad, K and Rostgaard-Hansen, AL and Tjonneland, A and Trichopoulou, A and Bamia, C and Lagiou, P and Agnoli, C and Mattiello, A and Bradbury, K and Khaw, K-T and Riboli, E and Boeing, H},
doi = {aje/kww194},
journal = {AMERICAN JOURNAL OF EPIDEMIOLOGY},
pages = {751--764},
title = {Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer: Data From the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort},
url = {http://dx.doi.org/10.1093/aje/kww194},
volume = {185},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The proportions of mediated effects (%) were estimated on the basis of differences in percent effect changes in conditional logistic regression models with and without additional adjustment for individual biomarkers. Greater adult weight gain (≥300 g/year vs. <300 g/year) was associated with a higher risk of colon cancer (multivariable-adjusted relative risk = 1.54, 95% confidence interval: 1.07, 2.24) but not rectal cancer (relative risk = 1.07, 95% confidence interval: 0.68, 1.66). This association was accounted for mostly by attained waist circumference (reduction of 61%) and by the biomarkers soluble leptin receptor (reduction of 43%) and glycated hemoglobin (reduction of 28%). These novel data suggest that the observed association between adult weight gain and colon cancer could be primarily explained by attained abdominal fatness and biomarkers of metabolic dysfunction.
AU  - Aleksandrova,K
AU  - Schlesinger,S
AU  - Fedirko,V
AU  - Jenab,M
AU  - Bueno-de-Mesquita,B
AU  - Freisling,H
AU  - Romieu,I
AU  - Pischon,T
AU  - Kaaks,R
AU  - Gunter,MJ
AU  - Dahm,CC
AU  - Overvad,K
AU  - Rostgaard-Hansen,AL
AU  - Tjonneland,A
AU  - Trichopoulou,A
AU  - Bamia,C
AU  - Lagiou,P
AU  - Agnoli,C
AU  - Mattiello,A
AU  - Bradbury,K
AU  - Khaw,K-T
AU  - Riboli,E
AU  - Boeing,H
DO  - aje/kww194
EP  - 764
PY  - 2017///
SN  - 0002-9262
SP  - 751
TI  - Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer: Data From the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort
T2  - AMERICAN JOURNAL OF EPIDEMIOLOGY
UR  - http://dx.doi.org/10.1093/aje/kww194
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401935800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48850
VL  - 185
ER  -
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