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@article{Chajes:2017:annonc/mdx482,
author = {Chajes, V and Assi, N and Biessy, C and Ferrari, P and Rinaldi, S and Slimani, N and Lenoir, GM and Baglietto, L and His, M and Boutron-Ruault, MC and Trichopoulou, A and Lagiou, P and Katsoulis, M and Kaaks, R and Kuhn, T and Panico, S and Pala, V and Bueno-de-Mesquita, HB and Peeters, PH and van, Gils C and Hjartåker, A and Standahl, Olsen K and Borgund, Barnung R and Barricarte, A and Redondo-Sanchez, D and Menéndez, V and Amiano, P and Wennberg, M and Key, T and Khaw, KT and Merritt, MA and Riboli, E and Gunter, MJ and Romieu, I},
doi = {annonc/mdx482},
journal = {Annals of Oncology},
pages = {2836--2842},
title = {A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study},
url = {http://dx.doi.org/10.1093/annonc/mdx482},
volume = {28},
year = {2017}
}

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TY  - JOUR
AB  - BackgroundIntakes of specific fatty acids have been postulated to impact breast cancer risk but epidemiological data based on dietary questionnaires remain conflicting.Materials and methodsWe assessed the association between plasma phospholipid fatty acids and breast cancer risk in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition study. Sixty fatty acids were measured by gas chromatography in pre-diagnostic plasma phospholipids from 2982 incident breast cancer cases matched to 2982 controls. Conditional logistic regression models were used to estimate relative risk of breast cancer by fatty acid level. The false discovery rate (q values) was computed to control for multiple comparisons. Subgroup analyses were carried out by estrogen receptor (ER) and progesterone receptor expression in the tumours.ResultsA high level of palmitoleic acid [odds ratio (OR) for the highest quartile compared with the lowest OR (Q4–Q1) 1.37; 95% confidence interval (CI), 1.14–1.64; P for trend = 0.0001, q value = 0.004] as well as a high desaturation index (DI16) (16:1n–7/16:0) [OR (Q4–Q1), 1.28; 95% C, 1.07–1.54; P for trend = 0.002, q value = 0.037], as biomarkers of de novo lipogenesis, were significantly associated with increased risk of breast cancer. Levels of industrial trans-fatty acids were positively associated with ER-negative tumours [OR for the highest tertile compared with the lowest (T3–T1)=2.01; 95% CI, 1.03–3.90; P for trend = 0.047], whereas no association was found for ER-positive tumours (P-heterogeneity =0.01). No significant association was found between n-3 polyunsaturated fatty acids and breast cancer risk, overall or by hormonal receptor.ConclusionThese findings suggest that increased de novo lipogenesis, acting through increased synthesis of palmitoleic acid, could be a relevant metabolic p
AU  - Chajes,V
AU  - Assi,N
AU  - Biessy,C
AU  - Ferrari,P
AU  - Rinaldi,S
AU  - Slimani,N
AU  - Lenoir,GM
AU  - Baglietto,L
AU  - His,M
AU  - Boutron-Ruault,MC
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Katsoulis,M
AU  - Kaaks,R
AU  - Kuhn,T
AU  - Panico,S
AU  - Pala,V
AU  - Bueno-de-Mesquita,HB
AU  - Peeters,PH
AU  - van,Gils C
AU  - Hjartåker,A
AU  - Standahl,Olsen K
AU  - Borgund,Barnung R
AU  - Barricarte,A
AU  - Redondo-Sanchez,D
AU  - Menéndez,V
AU  - Amiano,P
AU  - Wennberg,M
AU  - Key,T
AU  - Khaw,KT
AU  - Merritt,MA
AU  - Riboli,E
AU  - Gunter,MJ
AU  - Romieu,I
DO  - annonc/mdx482
EP  - 2842
PY  - 2017///
SN  - 0923-7534
SP  - 2836
TI  - A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study
T2  - Annals of Oncology
UR  - http://dx.doi.org/10.1093/annonc/mdx482
UR  - http://hdl.handle.net/10044/1/50348
VL  - 28
ER  -

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