Imperial College London
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Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aglago:2017:10.1194/jlr.P073643,
author = {Aglago, EK and Biessy, C and Torres-Mejia, G and Angeles-Llerenas, A and Gunter, MJ and Romieu, I and Chajes, V},
doi = {10.1194/jlr.P073643},
journal = {Journal of Lipid Research},
pages = {1462--1470},
title = {Association between serum phospholipid fatty acid levels and adiposity in Mexican women},
url = {http://dx.doi.org/10.1194/jlr.P073643},
volume = {58},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Fatty acids (FAs) have been postulated to impact adiposity, but few epidemiological studies addressing this hypothesis have been conducted. This study investigated the association between serum phospholipid FAs (S-PLFAs) and indicators of obesity. BMI and waist-to-hip ratio (WHR) were collected from 372 healthy Mexican women included as controls in a case-control study. S-PLFA percentages were determined through gas chromatography. Desaturation indices, SCD-16, SCD-18, FA desaturase (FADS)1, and FADS2, biomarkers of endogenous metabolism, were proxied respectively as 16:1n-7/16:0, 18:1n-9/18:0, 20:4n-6/20:3n-6, and 22:6n-3/20:5n-3. Multiple linear regressions adjusted for relevant confounders and corrected for multiple testing were conducted to determine the association between S-PLFA, desaturation indices, and indicators of adiposity. SCD-16 (β = 0.034, P = 0.001, q = 0.014), palmitoleic acid (β = 0.031, P = 0.001, q = 0.014), and dihomo-γ-linolenic acid (β = 0.043, P = 0.000, q = 0.0002) were positively associated with BMI. Total n-6 PUFAs (β = 1.497, P = 0.047, q = 0.22) and the ratio of n-6/n-3 PUFAs (β = 0.034, P = 0.040, q = 0.19) were positively associated with WHR, while odd-chain FAs (pentadecanoic and heptadecanoic acid) showed negative associations with all the adiposity indicators. In conclusion, increased endogenous synthesis of palmitoleic acid and a high n-6/n-3 ratio are associated with increased adiposity, while odd-chain FAs are associated with decreased adiposity. Further studies are needed to determine the potential causality behind these associations.
AU  - Aglago,EK
AU  - Biessy,C
AU  - Torres-Mejia,G
AU  - Angeles-Llerenas,A
AU  - Gunter,MJ
AU  - Romieu,I
AU  - Chajes,V
DO  - 10.1194/jlr.P073643
EP  - 1470
PY  - 2017///
SN  - 0022-2275
SP  - 1462
TI  - Association between serum phospholipid fatty acid levels and adiposity in Mexican women
T2  - Journal of Lipid Research
UR  - http://dx.doi.org/10.1194/jlr.P073643
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404576500017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.sciencedirect.com/science/article/pii/S0022227520335951?via%3Dihub
UR  - http://hdl.handle.net/10044/1/102204
VL  - 58
ER  -
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