Imperial College London
Alternate

Professor Dame Amanda Fisher

Faculty of Medicine, Institute of Clinical Sciences

Visiting Professor
 
 
 
//

Contact

 

amanda.fisher

 
 
//

Assistant

 

Ms Alessandra Lisini +44 (0)20 3313 8236

 
//

Location

 

CRB (Clinical Research Building)Hammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Hadjur:2009:10.1038/nature08079,
author = {Hadjur, S and Williams, LM and Ryan, NK and Cobb, BS and Sexton, T and Fraser, P and Fisher, AG and Merkenschlager, M},
doi = {10.1038/nature08079},
journal = {Nature},
pages = {410--U130},
title = {Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus},
url = {http://dx.doi.org/10.1038/nature08079},
volume = {460},
year = {2009}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cohesin-mediated sister chromatid cohesion is essential for chromosome segregation and post-replicative DNA repair1,2. In addition, evidence from model organisms3,4,5,6 and from human genetics7 suggests that cohesin is involved in the control of gene expression8,9. This non-canonical role has recently been rationalized by the findings that mammalian cohesin complexes are recruited to a subset of DNase I hypersensitive sites and to conserved noncoding sequences by the DNA-binding protein CTCF10,11,12,13. CTCF functions at insulators (which control interactions between enhancers and promoters) and at boundary elements (which demarcate regions of distinct chromatin structure)14, and cohesin contributes to its enhancer-blocking activity10,11. The underlying mechanisms remain unknown, and the full spectrum of cohesin functions remains to be determined. Here we show that cohesin forms the topological and mechanistic basis for cell-type-specific long-range chromosomal interactions in cis at the developmentally regulated cytokine locus IFNG. Hence, the ability of cohesin to constrain chromosome topology is used not only for the purpose of sister chromatid cohesion1,2, but also to dynamically define the spatial conformation of specific loci. This new aspect of cohesin function is probably important for normal development3,4,5,6 and disease7.
AU  - Hadjur,S
AU  - Williams,LM
AU  - Ryan,NK
AU  - Cobb,BS
AU  - Sexton,T
AU  - Fraser,P
AU  - Fisher,AG
AU  - Merkenschlager,M
DO  - 10.1038/nature08079
EP  - 130
PY  - 2009///
SN  - 0028-0836
SP  - 410
TI  - Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus
T2  - Nature
UR  - http://dx.doi.org/10.1038/nature08079
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000267979000042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71585
VL  - 460
ER  -
Download