Imperial College London
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Professor Anand Devaraj

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Thoracic Radiology)
 
 
 
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Contact

 

anand.devaraj Website

 
 
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Location

 

South BlockRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bartlett:2021:10.1007/s00330-021-08302-0,
author = {Bartlett, E and Kemp, S and Rawal, B and Devaraj, A},
doi = {10.1007/s00330-021-08302-0},
journal = {European Radiology},
pages = {1912--1920},
title = {Defining growth in small pulmonary nodules using volumetry: results from a "coffee-break" study and implications for current nodule management guidelines},
url = {http://dx.doi.org/10.1007/s00330-021-08302-0},
volume = {32},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives:An increase in lung nodule volume on serial CT may represent true growth or measurement variation. In nodule guidelines, a 25% increase in nodule volume is frequently used to determine that growth has occurred; this is based on previous same-day, test-retest (coffee-break) studies examining metastatic nodules. Whether results from prior studies apply to small non-metastatic nodules is unknown.  This study aimed to establish the interscan variability in the volumetric measurements of small-sized non-metastatic nodules.Methods:Institutional review board approval was obtained for this study. Between March 2019-January 2021, 45 adults (25 males; mean age 65yrs, range 37-84yrs) with previously identified pulmonary nodules (30-150mm3) requiring surveillance, without a known primary tumour, underwent two same-day CT scans. Non-calcified solid nodules were measured using commercial volumetry software, and interscan variability of volume measurements was assessed using a Bland-Altman method and limits of agreement. Results:One hundred nodules (range 28mm3-170mm3; mean 81.1mm3) were analysed. The lower and upper limits of agreement for the absolute volume difference between the two scans were -14.2mm3 and 12.0mm3 respectively (mean difference 1.09mm3, range -33mm3 – 12mm3). The lower and upper limits of agreement for relative volume difference were -16.4% and 14.6% respectively (mean difference 0.90%, range -24.1% - 32.8%). Conclusions:The interscan volume variability in this cohort of small non-metastatic nodules was smaller than in previous studies involving lung metastases of varying sizes. An increase of 15% in nodule volume on sequential CT may represent true growth and closer surveillance of these nodules may be warranted.
AU  - Bartlett,E
AU  - Kemp,S
AU  - Rawal,B
AU  - Devaraj,A
DO  - 10.1007/s00330-021-08302-0
EP  - 1920
PY  - 2021///
SN  - 0938-7994
SP  - 1912
TI  - Defining growth in small pulmonary nodules using volumetry: results from a "coffee-break" study and implications for current nodule management guidelines
T2  - European Radiology
UR  - http://dx.doi.org/10.1007/s00330-021-08302-0
UR  - https://link.springer.com/article/10.1007/s00330-021-08302-0
UR  - http://hdl.handle.net/10044/1/91662
VL  - 32
ER  -
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